Originalversjon
Genome Biology. 2016 Apr 07;17(1):54., DOI: http://dx.doi.org/10.1186/s13059-016-0923-2
Sammendrag
Genome-wide sequencing technologies enable investigations of the structural properties of the genome in various spatial dimensions. Here, we review computational techniques developed to model the three-dimensional genome in single cells versus ensembles of cells and assess their underlying assumptions. We further address approaches to study the spatio-temporal aspects of genome organization from single-cell data.