Browsing BioMed Central høstingsarkiv by Issue Date
Now showing items 1-20 of 3204
-
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2001)Treatment to prevent progression of heart failure has been targeted to reverse the consequences of heart failure and to a lesser extent the cause – the atherosclerotic plaque itself. Less than 50% of patients with heart ...
-
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2001)Inflammatory cytokines may negatively influence contractility and contribute to the remodelling process in the failing myocardium. Traditional cardiovascular drugs appear to have little influence on the overall cytokine ...
-
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2001)Background Activation of the extracellular signal-regulated kinases ERK1 and ERK2 in hepatocytes by prostaglandin (PG)F2α was recently found to be inhibited by pertussis toxin (PTX) suggesting a role for ...
-
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2001)Backround Laparoscopic adrenalectomy is a promising alternative to open surgery although concerns exist in regard to laparoscopic treatment of pheocromocytoma. This report compares the outcome of laparoscopic ...
-
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2001)Objective To explore whether there is a potential for greater use of research-based information in public health practice in a local setting. Secondly, if research-based information is relevant, to explore ...
-
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2002)Background Bilharzia-associated bladder cancer (BAC) is a major health problem in countries where urinary schistosomiasis is endemic. Characterization of the genetic alterations in this cancer might enhance ...
-
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2002)Background Cyclic AMP-dependent protein kinase (PKA) plays a central role in regulation of energy metabolism. Upon stimulation of testicular Sertoli cells by follicle stimulating hormone (FSH), glycolysis ...
-
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2002)Background T7 based linear amplification of RNA is used to obtain sufficient antisense RNA for microarray expression profiling. We optimized and systematically evaluated the fidelity and reproducibility ...
-
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2002)Background Previous studies have shown that several agents that stimulate heptahelical G-protein coupled receptors activate the extracellular signal regulated kinases ERK1 (p44mapk) and ERK2 (p42mapk) in ...
-
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2002)Background The International Personality Disorders Examination (IPDE) constitutes the proposal of the WHO for the reliable diagnosis of personality disorders (PD). The IPDE assesses pathological personality ...
-
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2002)Background A method to evaluate and analyze the massive data generated by series of microarray experiments is of utmost importance to reveal the hidden patterns of gene expression. Because of the complexity ...
-
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2003)Background The ability to react early to possible outbreaks of Escherichia coli O157:H7 and to trace possible sources relies on the availability of highly discriminatory and reliable techniques. The ...
-
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2003)Background A limiting factor of cDNA microarray technology is the need for a substantial amount of RNA per labeling reaction. Thus, 20–200 micro-grams total RNA or 0.5–2 micro-grams poly (A) RNA is typically ...
-
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2003)Background During infections, polymorphonuclear neutrophilic granulocytes (PMN) are mobilized from their bone marrow stores, travel with blood to the affected tissue, and kill invading microbes there. The ...
-
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2003)Background The underlying reasons for differences between clinical practice and systematically developed guidelines vary from one clinical problem to another. It is therefore logical to tailor strategies ...
-
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2003)Introduction The expression of the oestrogen receptor (ER) is one of the more important clinical parameters of breast cancer. However, the relationship between the ER and its ligand, oestradiol, and the ...
-
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2003)Background Using DNA microarrays, we have developed two novel models for tumor classification and target gene prediction. First, gene expression profiles are summarized by optimally selected Self-Organizing ...
-
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2004)Background Fast, cheap and reliable methods are needed to identify large populations, which may be at risk in relation to environmental exposure. Polymorphisms in NAT1 (N-acetyl transferase) may be suitable ...
-
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2004)Background Microarray-based comparative genomic hybridisation (array CGH) is a technique by which variation in relative copy numbers between two genomes can be analysed by competitive hybridisation to DNA ...
-
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2004)Background RSV is recognized as the most important cause of serious lower respiratory tract illness in infants and young children worldwide leading to hospitalisation in a great number of cases, especially ...