dc.contributor.author | Lilja-Lund, Otto | |
dc.contributor.author | Maripuu, Martin | |
dc.contributor.author | Kockum, Karin | |
dc.contributor.author | Andersson, Johanna | |
dc.contributor.author | Lindam, Anna | |
dc.contributor.author | Nyberg, Lars | |
dc.contributor.author | Laurell, Katarina | |
dc.date.accessioned | 2023-01-17T06:02:07Z | |
dc.date.available | 2023-01-17T06:02:07Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | BMC Geriatrics. 2023 Jan 16;23(1):29 | |
dc.identifier.uri | http://hdl.handle.net/10852/98838 | |
dc.description.abstract | Background
Idiopathic normal pressure hydrocephalus (iNPH) is a progressive syndrome affecting gait, incontinence, and cognition in a significant number of older adults. Still, prospective studies on early development of symptoms are scarce.
Aim
To investigate how neuropsychological functions develop before and in already diagnosed iNPH over a two-year period in a population-based material.
Method
A sample of 104 participants (median [IQR] 75 [72–80] years old) from the general population underwent CT-imaging and clinical assessment at baseline and follow-up. We used the iNPH symptom scale covering four domains (Neuropsychology, Gait, Balance, Incontinence) and additional tests of executive functions. Morphological signs were rated with the iNPH Radscale. Non-parametric statistics with Bonferroni corrections and a significance-level of p < 0.05 were used.
Results
Median (IQR) time to follow-up was 25 (23–26) months. Effect size (ES) for individuals who developed iNPH (n = 8) showed a large (ES r = -0.55) decline in the Gait domain and on the Radscale (ES r = -0.60), with a medium deterioration in declarative memory (ES r = -0.37). Those having iNPH at baseline (n = 12) performed worse on one executive sub-function i.e., shifting (p = 0.045).
Conclusion
Besides deterioration in gait and radiology, our results suggest that a neuropsychological trajectory for those developing iNPH includes a reduction in declarative memory. Executive dysfunction was limited to those already having iNPH at baseline. These findings could suggest that memory impairments are included in the early development of iNPH. | |
dc.language.iso | eng | |
dc.rights | The Author(s) | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.title | Longitudinal neuropsychological trajectories in idiopathic normal pressure hydrocephalus: a population–based study | |
dc.type | Journal article | |
dc.date.updated | 2023-01-17T06:02:07Z | |
dc.creator.author | Lilja-Lund, Otto | |
dc.creator.author | Maripuu, Martin | |
dc.creator.author | Kockum, Karin | |
dc.creator.author | Andersson, Johanna | |
dc.creator.author | Lindam, Anna | |
dc.creator.author | Nyberg, Lars | |
dc.creator.author | Laurell, Katarina | |
dc.identifier.doi | https://doi.org/10.1186/s12877-023-03747-y | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.type.version | PublishedVersion | |
cristin.articleid | 29 | |