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dc.contributor.authorLee-Ødegård, Sindre
dc.contributor.authorUeland, Thor
dc.contributor.authorThorsby, Per M.
dc.contributor.authorAukrust, Pål
dc.contributor.authorMichelsen, Annika E.
dc.contributor.authorHalvorsen, Bente
dc.contributor.authorDrevon, Christian A.
dc.contributor.authorBirkeland, Kåre I.
dc.date.accessioned2022-08-23T05:03:33Z
dc.date.available2022-08-23T05:03:33Z
dc.date.issued2022
dc.identifier.citationBMC Endocrine Disorders. 2022 Aug 17;22(1):208
dc.identifier.urihttp://hdl.handle.net/10852/95536
dc.description.abstractBackground South-Asian immigrants to Western countries have a high prevalence of type 2 diabetes mellitus (T2DM) and increased adipose tissue insulin resistance (AT-IR), as compared to their Western counterparts. Fetuin-A is a hepatokine known to influence AT-IR. Aim Can plasma fetuin-A concentrations explain an ethnic difference in adipose tissue insulin resistance? Methods We performed a two-step euglycemic-hyperinsulinaemic clamp and measured plasma concentrations of fetuin-A and non-esterified fatty acids (NEFA), in 18 Pakistani and 21 Norwegians with T2DM (age 29–45y) in Norway. AT-IR was calculated as NEFA-suppression during the clamp. The adipokines/cytokines leptin, adiponectin, visfatin, PTX3, IL-1β, INF-γ, and IL-4 were measured in fasting plasma. Liver fat was estimated by CT-scans. Results Despite a lower BMI, Pakistani patients displayed higher AT-IR than Norwegians. NEFA-suppression during clamp was lower in Pakistani than Norwegians (mean=-20.6%, 95%CI=[-40.8, -0.01] and p = 0.046). Plasma fetuin-A concentration was higher in Pakistani than Norwegians (43.4 ng/mL[12.7,74.0], p = 0.007) and correlated negatively to %NEFA-suppression during clamp (rho=-0.39, p = 0.039). Plasma fetuin-A concentration explained 22% of the ethnic difference in NEFA-suppression during the clamp. Pakistani patients exhibited higher plasma leptin and lower PTX3 levels than Norwegian, and plasma visfatin correlated positively to plasma fetuin-A levels in the Pakistani patients. We observed no correlation between plasma fetuin-A and liver fat, but fetuin-A correlated negatively with plasma IL-1β, INF-γ, and IL-4 concentrations. Plasma IL-4 concentration was lower in Pakistani than in Norwegian patients. Conclusion Fetuin-A may contribute to explain the discrepancy in T2DM prevalence between Pakistani and Norwegians patients by influencing AT-IR.
dc.language.isoeng
dc.rightsThe Author(s)
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleFetuin-A mediates the difference in adipose tissue insulin resistance between young adult pakistani and norwegian patients with type 2 diabetes
dc.typeJournal article
dc.date.updated2022-08-23T05:03:34Z
dc.creator.authorLee-Ødegård, Sindre
dc.creator.authorUeland, Thor
dc.creator.authorThorsby, Per M.
dc.creator.authorAukrust, Pål
dc.creator.authorMichelsen, Annika E.
dc.creator.authorHalvorsen, Bente
dc.creator.authorDrevon, Christian A.
dc.creator.authorBirkeland, Kåre I.
dc.identifier.cristin2065646
dc.identifier.doihttps://doi.org/10.1186/s12902-022-01127-y
dc.identifier.urnURN:NBN:no-98050
dc.type.documentTidsskriftartikkel
dc.type.peerreviewedPeer reviewed
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/95536/1/12902_2022_Article_1127.pdf
dc.type.versionPublishedVersion
cristin.articleid208


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