IL-18 and IL-18 binding protein are related to disease severity and parasitemia during falciparum malaria
dc.contributor.author | Otterdal, Kari | |
dc.contributor.author | Berg, Aase | |
dc.contributor.author | Michelsen, Annika E. | |
dc.contributor.author | Yndestad, Arne | |
dc.contributor.author | Patel, Sam | |
dc.contributor.author | Gregersen, Ida | |
dc.contributor.author | Halvorsen, Bente | |
dc.contributor.author | Ueland, Thor | |
dc.contributor.author | Langeland, Nina | |
dc.contributor.author | Aukrust, Pål | |
dc.date.accessioned | 2021-10-19T05:03:09Z | |
dc.date.available | 2021-10-19T05:03:09Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | BMC Infectious Diseases. 2021 Oct 18;21(1):1073 | |
dc.identifier.uri | http://hdl.handle.net/10852/88971 | |
dc.description.abstract | Background Several inflammatory molecules participate in the immune response to malaria. Interleukin (IL)-18 is an inflammatory cytokine activated by NLRP3 inflammasomes. In clinical falciparum malaria, with and without HIV co-infection, data on IL-18 and in particular on its binding protein, IL-18bp, is scarce. Methods Clinical data and blood samples were collected from adults in Mozambique with P. falciparum infection, with (n = 70) and without (n = 61) HIV co-infection, from HIV-infected patients with similar symptoms without malaria (n = 58) and from healthy controls (n = 52). In vitro studies were performed in endothelial cells using hemozoin crystals. Results (i) IL-18 and IL-18bp were markedly up-regulated during falciparum malaria with particular high levels in malaria patients co-infected with HIV and severe malaria disease. (ii) In the malaria group as a whole, both IL-18 and IL-18bp were positively correlated with disease severity, parasitemia, and endothelial cell activation as assessed by vWF in plasma. (iii) Whereas there was no change in IL-18 levels in malaria patients co-infected with HIV during follow-up, the patients with malaria only had slightly increased IL-18 levels. Further, the IL-18pb levels declined and thereby contributed to an increase in IL-18/IL-18bp ratio in all subgroups of malaria patients. (iv) IL-27, previously shown to be up-regulated in this malaria cohort, markedly induced a release of IL-18bp from endothelial cells in vitro, and notably, this presumably anti-inflammatory effect was counteracted by hemozoin. Conclusions Our findings suggest that the IL-18 system could be an important mediator in the immune pathogenesis during falciparum malaria, potentially also representing a target for therapy. | |
dc.language.iso | eng | |
dc.rights | The Author(s) | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.title | IL-18 and IL-18 binding protein are related to disease severity and parasitemia during falciparum malaria | |
dc.type | Journal article | |
dc.date.updated | 2021-10-19T05:03:09Z | |
dc.creator.author | Otterdal, Kari | |
dc.creator.author | Berg, Aase | |
dc.creator.author | Michelsen, Annika E. | |
dc.creator.author | Yndestad, Arne | |
dc.creator.author | Patel, Sam | |
dc.creator.author | Gregersen, Ida | |
dc.creator.author | Halvorsen, Bente | |
dc.creator.author | Ueland, Thor | |
dc.creator.author | Langeland, Nina | |
dc.creator.author | Aukrust, Pål | |
dc.identifier.cristin | 1952296 | |
dc.identifier.doi | https://doi.org/10.1186/s12879-021-06751-y | |
dc.identifier.urn | URN:NBN:no-91584 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/88971/1/12879_2021_Article_6751.pdf | |
dc.type.version | PublishedVersion | |
cristin.articleid | 1073 |
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