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dc.contributor.authorStolt, Emma
dc.contributor.authorOlsen, Thomas
dc.contributor.authorElshorbagy, Amany
dc.contributor.authorKožich, Viktor
dc.contributor.authorvan Greevenbroek, Marleen
dc.contributor.authorØvrebø, Bente
dc.contributor.authorThoresen, Magne
dc.contributor.authorRefsum, Helga
dc.contributor.authorRetterstøl, Kjetil
dc.contributor.authorVinknes, Kathrine J
dc.date.accessioned2021-04-20T05:02:24Z
dc.date.available2021-04-20T05:02:24Z
dc.date.issued2021
dc.identifier.citationJournal of Translational Medicine. 2021 Apr 15;19(1):153
dc.identifier.urihttp://hdl.handle.net/10852/85375
dc.description.abstractBackground Dietary sulfur amino acid (SAA) restriction is an established animal model for increasing lifespan and improving metabolic health. Data from human studies are limited. In the study outlined in this protocol, we will evaluate if dietary SAA restriction can reduce body weight and improve resting energy expenditure (REE) and parameters related to metabolic health. Method/design Men and women (calculated sample size = 60), aged 18–45 years, with body mass index of 27–35 kg/m2 will be included in a double-blind 8-week dietary intervention study. The participants will be randomized in a 1:1 manner to a diet with either low or high SAA. Both groups will receive an equal base diet consisting of low-SAA plant-based whole foods and an amino acid supplement free of SAA. Contrasting SAA contents will be achieved using capsules with or without methionine and cysteine (SAAhigh, total diet SAA ~ 50–60 mg/kg body weight/day; SAAlow, total diet SAA ~ 15–25 mg/kg body weight/day). The primary outcome is body weight change. Data and material collection will also include body composition (dual X-ray absorptiometry), resting energy expenditure (whole-room indirect calorimetry) and samples of blood, urine, feces and adipose tissue at baseline, at 4 weeks and at study completion. Measures will be taken to promote and monitor diet adherence. Data will be analyzed using linear mixed model regression to account for the repeated measures design and within-subject correlation. Discussion The strength of this study is the randomized double-blind design. A limitation is the restrictive nature of the diet which may lead to poor compliance. If this study reveals a beneficial effect of the SAAlow diet on body composition and metabolic health, it opens up for new strategies for prevention and treatment of overweight, obesity and its associated disorders. Trial registration ClinicalTrials.gov: NCT04701346, Registration date: January 8th, 2021
dc.language.isoeng
dc.rightsThe Author(s); licensee BioMed Central Ltd.
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleSulfur amino acid restriction, energy metabolism and obesity: a study protocol of an 8-week randomized controlled dietary intervention with whole foods and amino acid supplements
dc.typeJournal article
dc.date.updated2021-04-20T05:02:25Z
dc.creator.authorStolt, Emma
dc.creator.authorOlsen, Thomas
dc.creator.authorElshorbagy, Amany
dc.creator.authorKožich, Viktor
dc.creator.authorvan Greevenbroek, Marleen
dc.creator.authorØvrebø, Bente
dc.creator.authorThoresen, Magne
dc.creator.authorRefsum, Helga
dc.creator.authorRetterstøl, Kjetil
dc.creator.authorVinknes, Kathrine J
dc.identifier.cristin1905472
dc.identifier.doihttps://doi.org/10.1186/s12967-021-02824-3
dc.identifier.urnURN:NBN:no-88038
dc.type.documentTidsskriftartikkel
dc.type.peerreviewedPeer reviewed
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/85375/1/12967_2021_Article_2824.pdf
dc.type.versionPublishedVersion
cristin.articleid153


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