dc.contributor.author | Fredwall, Svein O | |
dc.contributor.author | Øverland, Britt | |
dc.contributor.author | Berdal, Hanne | |
dc.contributor.author | Berg, Søren | |
dc.contributor.author | Weedon-Fekjær, Harald | |
dc.contributor.author | Lidal, Ingeborg B | |
dc.contributor.author | Savarirayan, Ravi | |
dc.contributor.author | Månum, Grethe | |
dc.date.accessioned | 2021-04-13T05:02:06Z | |
dc.date.available | 2021-04-13T05:02:06Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Orphanet Journal of Rare Diseases. 2021 Apr 07;16(1):156 | |
dc.identifier.uri | http://hdl.handle.net/10852/85209 | |
dc.description.abstract | Background
Previous studies have found a high prevalence of obstructive sleep apnea (OSA) in children with achondroplasia, but clinical studies on this complication in adults with achondroplasia are lacking.
Objectives
This population-based, cross-sectional study investigated the prevalence, severity, and predictive factors of OSA in Norwegian adults with achondroplasia.
Methods
We collected clinical data on 49 participants. Participants without a preexisting diagnosis of OSA had an overnight sleep registration. OSA was defined as an apnea–hypopnea index (AHI) ≥ 5 plus characteristic clinical symptoms, or AHI ≥ 15. We used the Berlin Questionnaire to assess clinical symptoms of OSA.
Results
OSA was found in 59% (29/49) of the participants (95% confidence interval 44 to 73%), of whom 59% (17/29) had moderate to severe OSA (AHI ≥ 15), and 48% (14/29) were previously undiagnosed. Variables predictive of OSA were: excessive daytime sleepiness; unrested sleep; loud snoring; observed nocturnal breathing stops; hypertension; age > 40 years; and BMI > 30 kg/m2.
Conclusion
OSA was highly prevalent in Norwegian adults with achondroplasia, which we believe is representative of this population worldwide. Follow-up of adults with achondroplasia should include assessment of symptoms and signs of OSA, with a low threshold for conducting an overnight sleep registration if findings suggestive of OSA are present. | |
dc.language.iso | eng | |
dc.rights | The Author(s); licensee BioMed Central Ltd. | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.title | Obstructive sleep apnea in Norwegian adults with achondroplasia: a population-based study | |
dc.type | Journal article | |
dc.date.updated | 2021-04-13T05:02:08Z | |
dc.creator.author | Fredwall, Svein O | |
dc.creator.author | Øverland, Britt | |
dc.creator.author | Berdal, Hanne | |
dc.creator.author | Berg, Søren | |
dc.creator.author | Weedon-Fekjær, Harald | |
dc.creator.author | Lidal, Ingeborg B | |
dc.creator.author | Savarirayan, Ravi | |
dc.creator.author | Månum, Grethe | |
dc.identifier.cristin | 1917289 | |
dc.identifier.doi | https://doi.org/10.1186/s13023-021-01792-7 | |
dc.identifier.urn | URN:NBN:no-87760 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/85209/1/13023_2021_Article_1792.pdf | |
dc.type.version | PublishedVersion | |
cristin.articleid | 156 | |