dc.contributor.author | Olsen, Thomas | |
dc.contributor.author | Øvrebø, Bente | |
dc.contributor.author | Turner, Cheryl | |
dc.contributor.author | Bastani, Nasser E | |
dc.contributor.author | Refsum, Helga | |
dc.contributor.author | Vinknes, Kathrine J | |
dc.date.accessioned | 2021-02-09T06:02:32Z | |
dc.date.available | 2021-02-09T06:02:32Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | BMC Research Notes. 2021 Feb 02;14(1):43 | |
dc.identifier.uri | http://hdl.handle.net/10852/83093 | |
dc.description.abstract | Objective
In this 7-day pilot study we randomized healthy, normal-weight men and women to either a dietary intervention with methionine and cysteine restriction enriched in PUFA (Met/Cyslow + PUFA, n = 7) or with high contents of methionine, cysteine and SFA (Met/Cyshigh + SFA, n = 7). The objective was to describe the short-term responses in oral glucose tolerance, amino acid profile, total fatty acid profile, pyruvate and lactate following a Met/Cyslow + PUFA diet vs. Met/Cyshigh + SFA.
Results
The diet groups consisted of five women and two men, aged 20–38 years. After the 7-d intervention median pre- and post-oral glucose tolerance test (OGTT) glucose concentrations were 5 mmol/L and 4 mmol/L respectively in the Met/Cyslow + PUFA group. In the Met/Cyshigh + SFA group, median pre- and post-OGTT glucose concentrations were 4.8 mmol/L and 4.65 mmol/L after the 7-d intervention. The responses in the amino acid profiles were similar in both groups during the intervention with the exception of serine. Fatty acids decreased from baseline to day 7 in both groups. Plasma lactate and pyruvate were similar for both groups with an increase to day 3 before approaching baseline values at day 7.
Trial registration
ClinicalTrials.gov: NCT02647970, registration date: January 6th 2016. | |
dc.language.iso | eng | |
dc.rights | The Author(s) | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.title | Effects of short-term methionine and cysteine restriction and enrichment with polyunsaturated fatty acids on oral glucose tolerance, plasma amino acids, fatty acids, lactate and pyruvate: results from a pilot study | |
dc.type | Journal article | |
dc.date.updated | 2021-02-09T06:02:33Z | |
dc.creator.author | Olsen, Thomas | |
dc.creator.author | Øvrebø, Bente | |
dc.creator.author | Turner, Cheryl | |
dc.creator.author | Bastani, Nasser E | |
dc.creator.author | Refsum, Helga | |
dc.creator.author | Vinknes, Kathrine J | |
dc.identifier.cristin | 1885958 | |
dc.identifier.doi | https://doi.org/10.1186/s13104-021-05463-5 | |
dc.identifier.urn | URN:NBN:no-85869 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/83093/1/13104_2021_Article_5463.pdf | |
dc.type.version | PublishedVersion | |
cristin.articleid | 43 | |