Sammendrag
The mushroom product AndosanTM, which contains 82,4% of Agaricus blazei Murill, has been shown to have anti-inflammatory effect in vivo. In order to study the immunological effects of AndosanTM in multiple myeloma, 40 patients scheduled to receive high dose chemotherapy were randomized to receive either AndosanTM 60 ml daily (19 patients) or placebo (21 patients). In the group receiving AndosanTM increased serum levels of the cytokines Il-1ra ,IL-5 and Il-7, and increased quantities of Treg and plasmocyte derived dendritic cells in the blood were found. The changes may have had an influence on the treatment result, but the number of patients included in the study were not sufficient to reveal any statistically significant survival differences. Further studies showed that AndosanTM also had a cytotoxic effect on human myeloma cells in culture, inhibited the development of intestinal tumors in mice and had a cytotoxic effect on human cancer colon cells in culture. The studies indicate that AndosanTM has a biologic effect in cancer, but it will be necessary to determine further it’s mechanism of action and also to conduct larger patient studies
Artikkelliste
Paper 1.Tangen JM, Tryggestad AMA , Hetland G. Stimulation of human monocytic cells by the medicinal mushroom Agaricus blazei Murill induces expression of cell surface markers associated with activation and antigen presentation. Applied Scientific reports 214, doi:10.7243/2054-9903-1-1. The article is included in the thesis. Also available at https://doi.org/10.7243/2054-9903-1-1 |
Paper 2. Tangen JM, Tierens A, Caers J, Binsfeld M, Olstad OK, Siebke Trøseid A-M, Wang J, Tjønnfjord GE, Hetland G. Immunomodulatory effect of the Agaricus Blazei Murill based mushroom extract AndoSan in patients with multiple myeloma undergoing high dose chemotherapy and autologous stem cell transplantation: A randomized, double-blinded study. Biomed Res Int 2015. doi:10.1155/2015/718539. The article is included in the thesis. Also available at https://doi.org/10.1155/2015/718539 |
Paper 3. Tangen JM, Holien T, Mirlashari MH, Misund K, Hetland G. Cytotoxic effect on human myeloma cells and leukemic cells by the Agaricus blazei Murill based mushroom extract, AndosanTM. Biomed Res Int 2017. doi:10.1155/2017/2059825. The article is included in the thesis. Also available at https://doi.org/10.1155/2017/2059825 |
Paper 4. Hetland G, Eide DM, Tangen JM, Haugen MH, Mirlashari MR, Paulsen JE. The Agaricus blazei-based mushroom extract AndosanTM protects against intestinal tumorigenesis in the A/J Min + Mouse. Plos One.doi:10.1371/journal.pone.0167754. December 21, 2016. The article is included in the thesis. Also available at https://doi.org/10.1371/journal.pone.0167754 |
Paper 5. Tangen JM, Tjønnfjord GE, Gulbrandsen N, Gedde-Dahl T, Stormorken E, Anderson K, Dao Vo C, Schjesvold. Improved outcome in patients following autologous stem cell transplantation for multiple myeloma in South Eastern Norway 2001-1010. A retrospective, population-based analysis. BMC Cancer 2018 Aug 8;18(1):801. doi:10.1186/s12885-018-4722-x. The article is included in the thesis. Also available at https://doi.org/10.1186/s12885-018-4722-x |