dc.contributor.author | Holme, Sigrun Skaar | |
dc.contributor.author | Moen, Jon Magnus | |
dc.contributor.author | Kilian, Karin | |
dc.contributor.author | Haukeland, Hilde | |
dc.contributor.author | Molberg, Øyvind | |
dc.contributor.author | Eggesbø, Heidi B. | |
dc.date.accessioned | 2019-02-05T06:03:12Z | |
dc.date.available | 2019-02-05T06:03:12Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | BMC Medical Imaging. 2019 Feb 04;19(1):13 | |
dc.identifier.uri | http://hdl.handle.net/10852/66390 | |
dc.description.abstract | Background
Even though progressive rhinosinusitis with osteitis is a major clinical problem in granulomatosis with polyangiitis (GPA), there are no studies on how GPA-related osteitis develops over time, and no quantitative methods for longitudinal assessment.
Here, we aimed to identify simple and robust CT-based methods for capture and quantification of time-dependent changes in GPA-related paranasal sinus osteitis and compare performance of the methods under study in a largely unselected GPA cohort.
Methods
GPA patients (n = 121) with ≥3 paranasal CT scans obtained ≥12 months apart and control patients not having GPA or rhinosinusitis (n = 15) were analysed by: (i) Global osteitis scoring scale (GOSS), originally developed for chronic rhinosinusitis; (ii) Paranasal sinus volume by manual segmentation; (iii) Mean maxillary and sphenoid diameter normalised to landmark distances (i.e. diameter ratio measurement, DRM).
Results
Time-dependent changes in GPA-related osteitis were equally well measured by the simple DRM and the labour-intensive volume method while GOSS missed ongoing changes in cases with extensive osteitis. GOSS at last CT combined with DRM identified three distinct patient groups: (i) The no osteitis group, who had no osteitis and no change in DRM from baseline CT to last CT (45/121 GPA patients and 15/15 disease controls); (ii) Stable osteitis group, with presence of osteitis, but no change in DRM across time (31 GPA); (iii) Progressive osteitis, defined by declining DRM (45 GPA).
Conclusions
We suggest DRM and GOSS as complementary methods for capturing, classifying and quantifying time-dependent changes in GPA-related osteitis. | |
dc.language.iso | eng | |
dc.rights | The Author(s) | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.title | Development of CT-based methods for longitudinal analyses of paranasal sinus osteitis in granulomatosis with polyangiitis | |
dc.type | Journal article | |
dc.date.updated | 2019-02-05T06:03:15Z | |
dc.creator.author | Holme, Sigrun Skaar | |
dc.creator.author | Moen, Jon Magnus | |
dc.creator.author | Kilian, Karin | |
dc.creator.author | Haukeland, Hilde | |
dc.creator.author | Molberg, Øyvind | |
dc.creator.author | Eggesbø, Heidi B. | |
dc.identifier.cristin | 1674335 | |
dc.identifier.doi | https://doi.org/10.1186/s12880-019-0315-7 | |
dc.identifier.urn | URN:NBN:no-69598 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/66390/1/12880_2019_Article_315.pdf | |
dc.type.version | PublishedVersion | |
cristin.articleid | 13 | |