dc.contributor.author | Fjellaksel, Richard | |
dc.contributor.author | Oteiza, Ana | |
dc.contributor.author | Martin-Armas, Montserrat | |
dc.contributor.author | Riss, Patrick J | |
dc.contributor.author | Hjelstuen, Ole K | |
dc.contributor.author | Kuttner, Samuel | |
dc.contributor.author | Hansen, Jørn H | |
dc.contributor.author | Sundset, Rune | |
dc.date.accessioned | 2018-11-20T06:13:40Z | |
dc.date.available | 2018-11-20T06:13:40Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | BMC Research Notes. 2018 Nov 15;11(1):811 | |
dc.identifier.uri | http://hdl.handle.net/10852/65598 | |
dc.description.abstract | Objectives
In vivo evaluations of a gonadotropin releasing hormone-receptor single photon emission computed tomography radiotracer for non-invasive detection of gonadotropin releasing homone-receptors in brain.
Results
We have used a simple, robust and high-yielding procedure to radiolabel an alpha-halogenated bioactive compound with high radiochemical yield. Literature findings showed similar alpha-halogenated compounds suitable for in vivo evaluations. The compound was found to possess nano molar affinity for the gonadotropin releasing hormone-receptor in a competition dependent inhibition study. Furthermore, liquid chromatography-mass spectrometry analysis in saline, human and rat serum resulted in 46%, 52% and 44% stability after incubation for 1 h respectively. In addition, rat brain single photon emission computed tomography and biodistribution studies gave further insight into the nature of the compound as a radiotracer. | |
dc.language.iso | eng | |
dc.rights | The Author(s) | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.title | First in vivo evaluation of a potential SPECT brain radiotracer for the gonadotropin releasing hormone receptor | |
dc.type | Journal article | |
dc.date.updated | 2018-11-20T06:13:41Z | |
dc.creator.author | Fjellaksel, Richard | |
dc.creator.author | Oteiza, Ana | |
dc.creator.author | Martin-Armas, Montserrat | |
dc.creator.author | Riss, Patrick J | |
dc.creator.author | Hjelstuen, Ole K | |
dc.creator.author | Kuttner, Samuel | |
dc.creator.author | Hansen, Jørn H | |
dc.creator.author | Sundset, Rune | |
dc.identifier.cristin | 1631093 | |
dc.identifier.doi | https://doi.org/10.1186/s13104-018-3924-2 | |
dc.identifier.urn | URN:NBN:no-67888 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/65598/1/13104_2018_Article_3924.pdf | |
dc.type.version | PublishedVersion | |
cristin.articleid | 811 | |