Re-assessing ZNF331 as a DNA methylation biomarker for colorectal cancer
| dc.contributor.author | Vedeld, Hege M | |
| dc.contributor.author | Nesbakken, Arild | |
| dc.contributor.author | Lothe, Ragnhild A | |
| dc.contributor.author | Lind, Guro E | |
| dc.date.accessioned | 2018-06-05T05:50:08Z | |
| dc.date.available | 2018-06-05T05:50:08Z | |
| dc.date.issued | 2018 | |
| dc.identifier.citation | Clinical Epigenetics. 2018 May 29;10(1):70 | |
| dc.identifier.uri | http://hdl.handle.net/10852/61776 | |
| dc.description.abstract | We have previously shown that aberrant promoter methylation of ZNF331 is a potential biomarker for colorectal cancer detection with high sensitivity (71%) and specificity (98%). This finding was recently confirmed by others, and it was additionally suggested that promoter methylation of ZNF331 was an independent prognostic biomarker for colorectal cancer (n = 146). In the current study, our initial colorectal cancer sample series was extended to include a total of 423 cancer tissue samples. Aberrant promoter methylation was found in 71% of the samples, thus repeatedly suggesting the biomarker potential of ZNF331 for detection of colorectal cancer. Furthermore, multivariate Cox’s analysis indicated a trend towards inferior overall survival for colorectal cancer patients with aberrant methylation of ZNF331. | |
| dc.language.iso | eng | |
| dc.rights | The Author(s); licensee BioMed Central Ltd. | |
| dc.rights | Attribution 4.0 International | |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
| dc.title | Re-assessing ZNF331 as a DNA methylation biomarker for colorectal cancer | |
| dc.type | Journal article | |
| dc.date.updated | 2018-06-05T05:50:11Z | |
| dc.creator.author | Vedeld, Hege M | |
| dc.creator.author | Nesbakken, Arild | |
| dc.creator.author | Lothe, Ragnhild A | |
| dc.creator.author | Lind, Guro E | |
| dc.identifier.doi | https://doi.org/10.1186/s13148-018-0503-2 | |
| dc.identifier.urn | URN:NBN:no-64379 | |
| dc.type.document | Tidsskriftartikkel | |
| dc.type.peerreviewed | Peer reviewed | |
| dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/61776/1/13148_2018_Article_503.pdf | |
| dc.type.version | PublishedVersion | |
| cristin.articleid | 70 |
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