Haemodynamic outcomes during piston-based mechanical CPR with or without active decompression in a porcine model of cardiac arrest
dc.contributor.author | Steinberg, Mikkel T | |
dc.contributor.author | Olsen, Jan-Aage | |
dc.contributor.author | Eriksen, Morten | |
dc.contributor.author | Neset, Andres | |
dc.contributor.author | Norseng, Per A | |
dc.contributor.author | Kramer-Johansen, Jo | |
dc.contributor.author | Hardig, Bjarne M | |
dc.contributor.author | Wik, Lars | |
dc.date.accessioned | 2018-05-01T05:28:19Z | |
dc.date.available | 2018-05-01T05:28:19Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine. 2018 Apr 24;26(1):31 | |
dc.identifier.uri | http://hdl.handle.net/10852/61624 | |
dc.description.abstract | Background Experimental active compression-decompression (ACD) CPR is associated with increased haemodynamic outcomes compared to standard mechanical chest compressions. Since no clinically available mechanical chest compression device is capable of ACD-CPR, we modified the LUCAS 2 (Physio-Control, Lund, Sweden) to deliver ACD-CPR, hypothesising it would improve haemodynamic outcomes compared with standard LUCAS CPR on pigs with cardiac arrest. Methods The modified LUCAS delivering 5 cm compressions with or without 2 cm active decompression above anatomical chest level was studied in a randomized crossover design on 19 Norwegian domestic pigs. VF was electrically induced and untreated for 2 min. Each pig received ACD-CPR and standard mechanical CPR in three 180-s. phases. We measured aortic, right atrial, coronary perfusion, intracranial and oesophageal pressure, cerebral and carotid blood flow and cardiac output. Two-sided paired samples t-test was used for continuous parametric data and Wilcoxon test for non-parametric data. P < 0.05 was considered significant. Results Due to injuries/device failure, the experimental protocol was completed in nine of 19 pigs. Cardiac output (l/min, median, (25, 75-percentiles): 1.5 (1.1, 1.7) vs. 1.1 (0.8, 1.5), p < 0.01), cerebral blood flow (AU, 297 vs. 253, mean difference: 44, 95% CI; 14–74, p = 0.01), and carotid blood flow (l/min, median, (25, 75-percentiles): 97 (70, 106) vs. 83 (57, 94), p < 0.01) were higher during ACD-CPR compared to standard mechanical CPR. Coronary perfusion pressure (CPP) trended towards higher in end decompression phase. Conclusion Cardiac output and brain blood flow improved with mechanical ACD-CPR and CPP trended towards higher during end-diastole compared to standard LUCAS CPR. | |
dc.language.iso | eng | |
dc.relation.ispartof | Steinberg, Mikkel Torp (2018) The impact of chest compressions on defibrillation success during out-of-hospital cardiac arrest and haemodynamics in an experimental animal model. Doctoral thesis http://hdl.handle.net/10852/66001 | |
dc.relation.uri | http://hdl.handle.net/10852/66001 | |
dc.rights | The Author(s); licensee BioMed Central Ltd. | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.title | Haemodynamic outcomes during piston-based mechanical CPR with or without active decompression in a porcine model of cardiac arrest | |
dc.type | Journal article | |
dc.date.updated | 2018-05-01T05:28:22Z | |
dc.creator.author | Steinberg, Mikkel T | |
dc.creator.author | Olsen, Jan-Aage | |
dc.creator.author | Eriksen, Morten | |
dc.creator.author | Neset, Andres | |
dc.creator.author | Norseng, Per A | |
dc.creator.author | Kramer-Johansen, Jo | |
dc.creator.author | Hardig, Bjarne M | |
dc.creator.author | Wik, Lars | |
dc.identifier.cristin | 1582304 | |
dc.identifier.doi | https://doi.org/10.1186/s13049-018-0496-z | |
dc.identifier.urn | URN:NBN:no-64231 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/61624/1/13049_2018_Article_496.pdf | |
dc.type.version | PublishedVersion | |
cristin.articleid | 31 |
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