dc.contributor.author | Lekva, Tove | |
dc.contributor.author | Michelsen, Annika E | |
dc.contributor.author | Aukrust, Pål | |
dc.contributor.author | Henriksen, Tore | |
dc.contributor.author | Bollerslev, Jens | |
dc.contributor.author | Ueland, Thor | |
dc.date.accessioned | 2017-01-10T04:53:23Z | |
dc.date.available | 2017-01-10T04:53:23Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | Cardiovascular Diabetology. 2017 Jan 10;16(1):5 | |
dc.identifier.uri | http://hdl.handle.net/10852/53488 | |
dc.description.abstract | Background
Gestational diabetes mellitus (GDM) is a significant risk factor for cardiovascular disease (CVD) in later life, but the mechanism remains unclear. Adipokine imbalance in the presence of metabolic dysfunction may be a key event in promoting CVD. The aim of the study was to examine the relationships between GDM, cardiovascular risk, and plasma adiponectin, leptin and the leptin/adiponectin (L/A) ratio in pregnancy and at 5 years after the index pregnancy.
Methods
This population-based prospective cohort included 300 women who had an oral glucose tolerance test (OGTT) during pregnancy. Five years later, the OGTT was repeated along with dual-energy X-ray absorptiometry, lipid analysis, and pulse wave velocity analysis. Fasting adiponectin and leptin levels were measured four times during pregnancy and at follow-up.
Results
We found the L/A ratio higher in GDM women both during pregnancy and follow-up compared to non-GDM women. A high L/A ratio during pregnancy was associated with CV risk based on lipid ratios at follow-up, especially the TG/HDL-C ratio. Further, interaction analysis indicated that an increase in the L/A ratio of 1 unit was associated with a higher CV risk in GDM compared to normal pregnancy. Finally, low adiponectin levels independently predicted increased lipid ratios at follow-up.
Conclusions
Taken together, our findings suggest that high L/A ratio in pregnancy and in particularly in those with GDM are associated with an unfavorable CVD risk profile during follow-up. Future studies should investigate if a dysregulated leptin and adiponectin profile during pregnancy is associated with atherosclerotic disease during long-term follow-up. | |
dc.language.iso | eng | |
dc.rights | The Author(s); licensee BioMed Central Ltd. | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | Leptin and adiponectin as predictors of cardiovascular risk after gestational diabetes mellitus | |
dc.type | Journal article | |
dc.date.updated | 2017-01-10T04:53:23Z | |
dc.creator.author | Lekva, Tove | |
dc.creator.author | Michelsen, Annika E | |
dc.creator.author | Aukrust, Pål | |
dc.creator.author | Henriksen, Tore | |
dc.creator.author | Bollerslev, Jens | |
dc.creator.author | Ueland, Thor | |
dc.identifier.doi | http://dx.doi.org/10.1186/s12933-016-0492-4 | |
dc.identifier.urn | URN:NBN:no-56690 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/53488/1/12933_2016_Article_492.pdf | |
dc.type.version | PublishedVersion | |
cristin.articleid | 5 | |