dc.contributor.author | Bergan, Harald A | |
dc.contributor.author | Halvorsen, Per S | |
dc.contributor.author | Skulstad, Helge | |
dc.contributor.author | Fosse, Erik | |
dc.contributor.author | Bugge, Jan F | |
dc.date.accessioned | 2016-12-27T04:27:37Z | |
dc.date.available | 2016-12-27T04:27:37Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | Journal of Translational Medicine. 2016 Dec 20;14(1):345 | |
dc.identifier.uri | http://hdl.handle.net/10852/53347 | |
dc.description.abstract | Background
Extracorporeal cardiopulmonary resuscitation (E-CPR) is increasingly used as a rescue method in the management of cardiac arrest and provides the opportunity to rapidly induce therapeutic hypothermia. The survival after a cardiac arrest is related to post-arrest cardiac function, and the application of therapeutic hypothermia post-arrest is hypothesized to improve cardiac outcome. The present animal study compares normothermic and hypothermic E-CPR considering resuscitation success, post-arrest left ventricular function and magnitude of myocardial injury.
Methods
After a 15-min untreated ventricular fibrillation, the pigs (n = 20) were randomized to either normothermic (38 °C) or hypothermic (32–33 °C) E-CPR. Defibrillation terminated ventricular fibrillation after 5 min of E-CPR, and extracorporeal support continued for 2 h, followed by warming, weaning and a stabilization period. Magnetic resonance imaging and left ventricle pressure measurements were used to assess left ventricular function pre-arrest and 5 h post-arrest. Myocardial injury was estimated by serum concentrations of cardiac TroponinT and Aspartate transaminase (ASAT).
Results
E-CPR resuscitated all animals and the hypothermic strategy induced therapeutic hypothermia within minutes without impairment of the resuscitation success rate. All animals suffered a severe global systolic left ventricular dysfunction post-arrest with 50–70% reductions in stroke volume, ejection fraction, wall thickening, strain and mitral annular plane systolic excursion. Serum concentrations of cardiac TroponinT and ASAT increased considerably post-arrest. No significant differences were found between the two groups.
Conclusions
Two-hour therapeutic hypothermia during E-CPR offers an equal resuscitation success rate, but does not preserve the post-arrest cardiac function nor reduce the magnitude of myocardial injury, compared to normothermic E-CPR.
Trial registration FOTS 4611/13 registered 25 October 2012 | |
dc.language.iso | eng | |
dc.rights | The Author(s); licensee BioMed Central Ltd. | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | Does therapeutic hypothermia during extracorporeal cardiopulmonary resuscitation preserve cardiac function? | |
dc.type | Journal article | |
dc.date.updated | 2016-12-27T04:27:37Z | |
dc.creator.author | Bergan, Harald A | |
dc.creator.author | Halvorsen, Per S | |
dc.creator.author | Skulstad, Helge | |
dc.creator.author | Fosse, Erik | |
dc.creator.author | Bugge, Jan F | |
dc.identifier.doi | http://dx.doi.org/10.1186/s12967-016-1099-y | |
dc.identifier.urn | URN:NBN:no-56580 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/53347/1/12967_2016_Article_1099.pdf | |
dc.type.version | PublishedVersion | |
cristin.articleid | 345 | |