dc.contributor.author | Eggemoen, Åse R | |
dc.contributor.author | Falk, Ragnhild S | |
dc.contributor.author | Knutsen, Kirsten V | |
dc.contributor.author | Lagerløv, Per | |
dc.contributor.author | Sletner, Line | |
dc.contributor.author | Birkeland, Kåre I | |
dc.contributor.author | Jenum, Anne K | |
dc.date.accessioned | 2016-01-26T05:23:17Z | |
dc.date.available | 2016-01-26T05:23:17Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | BMC Pregnancy and Childbirth. 2016 Jan 19;16(1):7 | |
dc.identifier.uri | http://hdl.handle.net/10852/48724 | |
dc.description.abstract | Background
To investigate ethnic differences in vitamin D levels during pregnancy, assess risk factors for vitamin D deficiency and explore the effect of vitamin D supplementation in women with deficiency in early pregnancy.
Methods
This is a population-based, multiethnic cohort study of pregnant women attending Child Health Clinics for antenatal care in Oslo, Norway. Serum-25-hydroxyvitamin D [25(OH)D] was measured in 748 pregnant women (59 % ethnic minorities) at gestational weeks (GW) 15 (SD:3.6) and 28 (1.4). Women with 25(OH)D <37 nmol/L at GW 15 were for ethical reasons recommended vitamin D3 supplementation. Main outcome measure was 25(OH)D, and linear regression models were performed.
Results
Severe deficiency (25(OH)D <25 nmol/L) was found at GW 15 in 45 % of women from South Asia, 40 % from the Middle East and 26 % from Sub-Saharan Africa, compared to 2.5 % in women from East Asia and 1.3 % of women from Western Europe. Women from South Asia, the Middle East and Sub-Saharan Africa had mean values that were −28 (95 % CI:-33, −23), −24 (−29, −18) and −20 (−27, −13) nmol/L lower than in Western women, respectively. Ethnicity, education, season and intake of vitamin D were independently associated with 25(OH)D. At GW 28, the mean 25(OH)D had increased from 23 (SD:7.8) to 47 (27) nmol/L (p < 0.01) in women who were recommended vitamin D supplementation, with small or no change in women with sufficient vitamin D levels at baseline.
Conclusions
Vitamin D deficiency was prevalent among South Asian, Middle Eastern and African women. The serum levels of 25(OH)D increased significantly from GW 15 to 28 in vitamin D deficient women who received a recommendation for supplementation. This recommendation of vitamin D supplementation increased vitamin D levels in deficient women. | |
dc.language.iso | eng | |
dc.relation.ispartof | Eggemoen, Åse Ruth (2018) Vitamin D and pregnancy. Vitamin D deficiency and associations with gestational diabetes and neonatal body composition in a multi-ethnic population. Doctoral thesis http://hdl.handle.net/10852/61863 | |
dc.relation.uri | http://hdl.handle.net/10852/61863 | |
dc.rights | Eggemoen et al. | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | Vitamin D deficiency and supplementation in pregnancy in a multiethnic population-based cohort | |
dc.type | Journal article | |
dc.date.updated | 2016-01-26T05:23:17Z | |
dc.creator.author | Eggemoen, Åse R | |
dc.creator.author | Falk, Ragnhild S | |
dc.creator.author | Knutsen, Kirsten V | |
dc.creator.author | Lagerløv, Per | |
dc.creator.author | Sletner, Line | |
dc.creator.author | Birkeland, Kåre I | |
dc.creator.author | Jenum, Anne K | |
dc.identifier.doi | http://dx.doi.org/10.1186/s12884-016-0796-0 | |
dc.identifier.urn | URN:NBN:no-52574 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/48724/1/12884_2016_Article_796.pdf | |
dc.type.version | PublishedVersion | |
cristin.articleid | 7 | |