dc.contributor.author | Kessler, Ute | |
dc.contributor.author | Schoeyen, Helle K | |
dc.contributor.author | Andreassen, Ole A | |
dc.contributor.author | Eide, Geir E | |
dc.contributor.author | Hammar, Åsa | |
dc.contributor.author | Malt, Ulrik F | |
dc.contributor.author | Oedegaard, Ketil J | |
dc.contributor.author | Morken, Gunnar | |
dc.contributor.author | Sundet, Kjetil | |
dc.contributor.author | Vaaler, Arne E | |
dc.date.accessioned | 2015-10-20T10:52:55Z | |
dc.date.available | 2015-10-20T10:52:55Z | |
dc.date.issued | 2013 | |
dc.identifier.citation | BMC Psychiatry. 2013 Apr 04;13(1):105 | |
dc.identifier.uri | http://hdl.handle.net/10852/47014 | |
dc.description.abstract | Background
The literature on the neuropsychological profiles in Bipolar disorder (BD) depression is sparse. The aims of the study were to assess the neurocognitive profiles in treatment-resistant, acutely admitted BD depression inpatients, to compare the neurocognitive functioning in patients with BD I and II, and to identify the demographic and clinical illness characteristics associated with cognitive functioning.
Methods
Acutely admitted BD I (n = 19) and BD II (n = 32) inpatients who fulfilled the DSM-IV-TR criteria for a major depressive episode were tested with the MATRICS Consensus Cognitive Battery (MCCB), the Wechsler Abbreviated Scale of Intelligence, the National Adult Reading Test, and a battery of clinical measures.
Results
Neurocognitive impairments were evident in the BD I and BD II depression inpatients within all MCCB domains. The numerical scores on all MCCB-measures were lower in the BD I group than in the BD II group, with a significant difference on one of the measures, category fluency. 68.4% of the BD I patients had clinically significant impairment (>1.5 SD below normal mean) in two or more domains compared to 37.5% of the BD II patients (p = 0.045). A significant reduction in IQ from the premorbid to the current level was seen in BD I but not BD II patients. Higher age was associated with greater neurocognitive deficits compared to age-adjusted published norms.
Conclusions
A high proportion of patients with therapy-resistant BD I or II depression exhibited global neurocognitive impairments with clinically significant severity. The cognitive impairments were more common in BD I compared to BD II patients, particularly processing speed. These findings suggest that clinicians should be aware of the severe neurocognitive dysfunction in treatment-resistant bipolar depression, particularly in BD I.
Trial registration
Trial registration number:
NCT00664976 | |
dc.language.iso | eng | |
dc.rights | Kessler et al.; licensee BioMed Central Ltd. | |
dc.rights | Attribution 2.0 Generic | |
dc.rights.uri | http://creativecommons.org/licenses/by/2.0/ | |
dc.title | Neurocognitive profiles in treatment-resistant bipolar I and bipolar II disorder depression | |
dc.type | Journal article | |
dc.date.updated | 2015-10-20T10:52:56Z | |
dc.creator.author | Kessler, Ute | |
dc.creator.author | Schoeyen, Helle K | |
dc.creator.author | Andreassen, Ole A | |
dc.creator.author | Eide, Geir E | |
dc.creator.author | Hammar, Åsa | |
dc.creator.author | Malt, Ulrik F | |
dc.creator.author | Oedegaard, Ketil J | |
dc.creator.author | Morken, Gunnar | |
dc.creator.author | Sundet, Kjetil | |
dc.creator.author | Vaaler, Arne E | |
dc.identifier.doi | http://dx.doi.org/10.1186/1471-244X-13-105 | |
dc.identifier.urn | URN:NBN:no-51168 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/47014/1/12888_2013_Article_1295.pdf | |
dc.type.version | PublishedVersion | |
cristin.articleid | 105 | |