dc.contributor.author | Hoff, Mari | |
dc.contributor.author | Haugeberg, Glenn | |
dc.contributor.author | Kvien, Tore K | |
dc.date.accessioned | 2015-10-09T02:14:53Z | |
dc.date.available | 2015-10-09T02:14:53Z | |
dc.date.issued | 2007 | |
dc.identifier.citation | Arthritis Research & Therapy. 2007 Aug 17;9(4):R81 | |
dc.identifier.uri | http://hdl.handle.net/10852/46851 | |
dc.description.abstract | The aim of this 2-year longitudinal observational study was to explore hand bone loss as a disease outcome measure in established rheumatoid arthritis (RA).
A cohort of 215 patients with RA (170 women and 45 men, aged 20–70 years) were recruited from the Oslo RA registry and studied for changes in hand bone mass during a 2-year follow-up. Digital X-ray radiogrammetry (DXR) was used to measure cortical hand bone mineral density (BMD) and metacarpal cortical index, whereas dual-energy X-ray absorptiometry (DXA) was used to assess whole hand BMD, which measures total cortical and trabecular bone. DXA-BMD total hip and spine and informative data for disease and therapy were also collected.
Hand bone loss could be revealed over a 2-year follow-up measured by DXR-BMD (-0.90%, P < 0.01), but not by DXA-BMD (0.00%, P = 0.87). DXA-BMD hand bone loss was only observed in patients with disease duration ≤3 years and not in patients with longer disease duration (-0.96% versus 0.24%, P < 0.01), whereas loss of DXR-BMD was independent of disease duration. Disease activity (measured by the disease activity score including 28 joints) independently predicted loss of DXR-BMD but not changes in the DXA-BMD hand in the multivariate analysis. The change in DXR metacarpal cortical index was highly correlated to DXR-BMD (r = 0.94, P < 0.001).
These data suggest that DXR-BMD may be a more appropriate technique to identify RA-related bone involvement in hands compared with DXA-BMD measurement, but further studies are needed to explore this hypothesis. | |
dc.language.iso | eng | |
dc.rights | Hoff et al..;licensee BioMed Central Ltd. | |
dc.rights | Attribution 2.0 Generic | |
dc.rights.uri | http://creativecommons.org/licenses/by/2.0/ | |
dc.title | Hand bone loss as an outcome measure in established rheumatoid arthritis: 2-year observational study comparing cortical and total bone loss | |
dc.type | Journal article | |
dc.date.updated | 2015-10-09T02:14:53Z | |
dc.creator.author | Hoff, Mari | |
dc.creator.author | Haugeberg, Glenn | |
dc.creator.author | Kvien, Tore K | |
dc.identifier.doi | http://dx.doi.org/10.1186/ar2280 | |
dc.identifier.urn | URN:NBN:no-51023 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/46851/1/13075_2007_Article_2131.pdf | |
dc.type.version | PublishedVersion | |
cristin.articleid | R81 | |