dc.contributor.author | Lindner, Ewald | |
dc.contributor.author | Nordang, Gry B | |
dc.contributor.author | Melum, Espen | |
dc.contributor.author | Flatø, Berit | |
dc.contributor.author | Selvaag, Anne M | |
dc.contributor.author | Thorsby, Erik | |
dc.contributor.author | Kvien, Tore K | |
dc.contributor.author | Førre, Øystein T | |
dc.contributor.author | Lie, Benedicte A | |
dc.date.accessioned | 2015-10-09T02:14:40Z | |
dc.date.available | 2015-10-09T02:14:40Z | |
dc.date.issued | 2007 | |
dc.identifier.citation | BMC Medical Genetics. 2007 Jun 12;8(1):33 | |
dc.identifier.uri | http://hdl.handle.net/10852/46842 | |
dc.description.abstract | Background
The chemokine receptor CCR5 has been detected at elevated levels on synovial T cells, and a 32 bp deletion in the CCR5 gene leads to a non-functional receptor. A negative association between the CCR5Δ32 and rheumatoid arthritis (RA) has been reported, although with conflicting results. In juvenile idiopathic arthritis (JIA), an association with CCR5 was recently reported. The purpose of this study was to investigate if the CCR5Δ32 polymorphism is associated with RA or JIA in Norwegian cohorts.
Methods
853 RA patients, 524 JIA patients and 658 controls were genotyped for the CCR5Δ32 polymorphism.
Results
The CCR5Δ32 allele frequency was 11.5% in the controls vs. 10.4% in RA patients (OR = 0.90; P = 0.36) and 9.7% in JIA patients (OR = 0.85; P = 0.20). No decreased homozygosity was observed for CCR5Δ32, as previously suggested.
Conclusion
Our data do not support an association between the CCR5Δ32 allele and Norwegian RA or JIA patients. Combining our results with those from a recently published meta-analysis still provide evidence for a role for CCR5Δ32 in RA, albeit substantially weaker than the effect first reported. | |
dc.language.iso | eng | |
dc.rights | Lindner et al; licensee BioMed Central Ltd. | |
dc.rights | Attribution 2.0 Generic | |
dc.rights.uri | http://creativecommons.org/licenses/by/2.0/ | |
dc.title | Lack of association between the chemokine receptor 5 polymorphism CCR5delta32 in rheumatoid arthritis and juvenile idiopathic arthritis | |
dc.type | Journal article | |
dc.date.updated | 2015-10-09T02:14:41Z | |
dc.creator.author | Lindner, Ewald | |
dc.creator.author | Nordang, Gry B | |
dc.creator.author | Melum, Espen | |
dc.creator.author | Flatø, Berit | |
dc.creator.author | Selvaag, Anne M | |
dc.creator.author | Thorsby, Erik | |
dc.creator.author | Kvien, Tore K | |
dc.creator.author | Førre, Øystein T | |
dc.creator.author | Lie, Benedicte A | |
dc.identifier.doi | http://dx.doi.org/10.1186/1471-2350-8-33 | |
dc.identifier.urn | URN:NBN:no-51022 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/46842/1/12881_2006_Article_227.pdf | |
dc.type.version | PublishedVersion | |
cristin.articleid | 33 | |