dc.contributor.author | Kersten, Christian | |
dc.contributor.author | Sivertsen, Einar A | |
dc.contributor.author | Hystad, Marit E | |
dc.contributor.author | Forfang, Lise | |
dc.contributor.author | Smeland, Erlend B | |
dc.contributor.author | Myklebust, June H | |
dc.date.accessioned | 2015-10-09T02:13:32Z | |
dc.date.available | 2015-10-09T02:13:32Z | |
dc.date.issued | 2005 | |
dc.identifier.citation | BMC Immunology. 2005 May 09;6(1):9 | |
dc.identifier.uri | http://hdl.handle.net/10852/46796 | |
dc.description.abstract | Background
Bone morphogenetic proteins (BMPs) belong to the TGF-β superfamily and are secreted proteins with pleiotropic roles in many different cell types. A potential role of BMP-6 in the immune system has been implied by various studies of malignant and rheumatoid diseases. In the present study, we explored the role of BMP-6 in normal human peripheral blood B cells.
Results
The B cells were found to express BMP type I and type II receptors and BMP-6 rapidly induced phosphorylation of Smad1/5/8. Furthermore, Smad-phosphorylation was followed by upregulation of Id1 mRNA and Id1 protein, whereas Id2 and Id3 expression was not affected. Furthermore, we found that BMP-6 had an antiproliferative effect both in naïve (CD19+CD27-) and memory B cells (CD19+CD27+) stimulated with anti-IgM alone or the combined action of anti-IgM and CD40L. Additionally, BMP-6 induced cell death in activated memory B cells. Importantly, the antiproliferative effect of BMP-6 in B-cells was completely neutralized by the natural antagonist, noggin. Furthermore, B cells were demonstrated to upregulate BMP-6 mRNA upon stimulation with anti-IgM.
Conclusion
In mature human B cells, BMP-6 inhibited cell growth, and rapidly induced phosphorylation of Smad1/5/8 followed by an upregulation of Id1. | |
dc.language.iso | eng | |
dc.rights | Kersten et al; licensee BioMed Central Ltd. | |
dc.rights | Attribution 2.0 Generic | |
dc.rights.uri | http://creativecommons.org/licenses/by/2.0/ | |
dc.title | BMP-6 inhibits growth of mature human B cells; induction of Smad phosphorylation and upregulation of Id1 | |
dc.type | Journal article | |
dc.date.updated | 2015-10-09T02:13:33Z | |
dc.creator.author | Kersten, Christian | |
dc.creator.author | Sivertsen, Einar A | |
dc.creator.author | Hystad, Marit E | |
dc.creator.author | Forfang, Lise | |
dc.creator.author | Smeland, Erlend B | |
dc.creator.author | Myklebust, June H | |
dc.identifier.doi | http://dx.doi.org/10.1186/1471-2172-6-9 | |
dc.identifier.urn | URN:NBN:no-50976 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/46796/1/12865_2004_Article_70.pdf | |
dc.type.version | PublishedVersion | |
cristin.articleid | 9 | |