The clinicopathological and prognostic impact of 14-3-3 sigma expression on vulvar squamous cell carcinomas
dc.contributor.author | Wang, Zhihui | |
dc.contributor.author | Tropè, Claes G | |
dc.contributor.author | Suo, Zhenhe | |
dc.contributor.author | Trøen, Gunhild | |
dc.contributor.author | Yang, Guanrui | |
dc.contributor.author | Nesland, Jahn M | |
dc.contributor.author | Holm, Ruth | |
dc.date.accessioned | 2015-10-09T02:09:52Z | |
dc.date.available | 2015-10-09T02:09:52Z | |
dc.date.issued | 2008 | |
dc.identifier.citation | BMC Cancer. 2008 Oct 24;8(1):308 | |
dc.identifier.uri | http://hdl.handle.net/10852/46639 | |
dc.description.abstract | Background 14-3-3 sigma (σ) promotes G2/M cell cycle arrest by sequestering cyclin B1-CDC2 complex in cytoplasm. Down-regulation of 14-3-3σ, which has been demonstrated in various carcinomas, may contribute to malignant transformation. However, the exact role of 14-3-3σ in the pathogenesis of vulvar carcinoma is not fully characterized, and the prognostic impact of 14-3-3σ protein expression is still unknown. Methods We investigated the 14-3-3σ expression in a series of 302 vulvar squamous cell carcinomas using immunohistochemistry and its associations with clinicopathological factors and clinical outcome. Results In cytoplasm, nucleus and cytoplasm/nucleus of vulvar carcinomas high 14-3-3σ protein expression was found in 72%, 59% and 75% of the carcinomas, respectively, and low levels in 28%, 41% and 25% of the cases, respectively. High level of 14-3-3σ in cytoplasm, nucleus and cytoplasm/nucleus was significantly correlated to large tumor diameter (p = 0.001, p = 0.002 and p = 0.001, respectively) and deep invasion (p = 0.01, p = 0.001 and p = 0.007, respectively). Variations of 14-3-3σ protein expression were not associated to disease-specific survival. Conclusion Our results indicate that 14-3-3σ may be involved in the development of a subset of vulvar squamous cell carcinomas by down-regulation of 14-3-3σ protein. Neither cytoplasmic nor nuclear level of 14-3-3σ expression was associated with prognosis. | |
dc.language.iso | eng | |
dc.rights | Wang et al. | |
dc.rights | Attribution 2.0 Generic | |
dc.rights.uri | http://creativecommons.org/licenses/by/2.0/ | |
dc.title | The clinicopathological and prognostic impact of 14-3-3 sigma expression on vulvar squamous cell carcinomas | |
dc.type | Journal article | |
dc.date.updated | 2015-10-09T02:09:53Z | |
dc.creator.author | Wang, Zhihui | |
dc.creator.author | Tropè, Claes G | |
dc.creator.author | Suo, Zhenhe | |
dc.creator.author | Trøen, Gunhild | |
dc.creator.author | Yang, Guanrui | |
dc.creator.author | Nesland, Jahn M | |
dc.creator.author | Holm, Ruth | |
dc.identifier.doi | http://dx.doi.org/10.1186/1471-2407-8-308 | |
dc.identifier.urn | URN:NBN:no-50821 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/46639/1/12885_2008_Article_1246.pdf | |
dc.type.version | PublishedVersion | |
cristin.articleid | 308 |
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