dc.contributor.author | Provan, Sella A | |
dc.contributor.author | Angel, Kristin | |
dc.contributor.author | Ødegård, Sigrid | |
dc.contributor.author | Mowinckel, Petter | |
dc.contributor.author | Atar, Dan | |
dc.contributor.author | Kvien, Tore K | |
dc.date.accessioned | 2015-10-09T01:02:03Z | |
dc.date.available | 2015-10-09T01:02:03Z | |
dc.date.issued | 2008 | |
dc.identifier.citation | Arthritis Research & Therapy. 2008 Jun 23;10(3):R70 | |
dc.identifier.uri | http://hdl.handle.net/10852/46267 | |
dc.description.abstract | Introduction
Disease activity in patients with rheumatoid arthritis (RA) is associated with increased cardiovascular morbidity and mortality, of which N-terminal pro-brain natriuretic peptide (NT-proBNP) is a predictor. Our objective was to examine the cross-sectional and longitudinal associations between markers of inflammation, measures of RA disease activity, medication used in the treatment of RA, and NT-proBNP levels (dependent variable).
Methods
Two hundred thirty-eight patients with RA of less than 4 years in duration were followed longitudinally with three comprehensive assessments of clinical and radiographic data over a 10-year period. Serum samples were frozen and later batch-analyzed for NT-proBNP levels and other biomarkers. Bivariate, multivariate, and repeated analyses were performed.
Results
C-reactive protein (CRP) levels at baseline were cross-sectionally associated with NT-proBNP levels after adjustment for age and gender (r
2 adjusted = 0.23; P < 0.05). At the 10-year follow-up, risk factors for cardiovascular disease were recorded. Duration of RA and CRP levels were independently associated with NT-proBNP in the final model that was adjusted for gender, age, and creatinine levels (r
2 adjusted = 0.38; P < 0.001). In the longitudinal analyses, which adjusted for age, gender, and time of follow-up, we found that repeated measures of CRP predicted NT-proBNP levels (P < 0.001).
Conclusion
CRP levels are linearly associated with levels of NT-proBNP in cross-sectional and longitudinal analyses of patients with RA. The independent associations of NT-proBNP levels and markers of disease activity with clinical cardiovascular endpoints need to be further investigated. | |
dc.language.iso | eng | |
dc.rights | Provan et al; licensee BioMed Central Ltd. | |
dc.rights | Attribution 2.0 Generic | |
dc.rights.uri | http://creativecommons.org/licenses/by/2.0/ | |
dc.title | The association between disease activity and NT-proBNP in 238 patients with rheumatoid arthritis: a 10-year longitudinal study | |
dc.type | Journal article | |
dc.date.updated | 2015-10-09T01:02:03Z | |
dc.creator.author | Provan, Sella A | |
dc.creator.author | Angel, Kristin | |
dc.creator.author | Ødegård, Sigrid | |
dc.creator.author | Mowinckel, Petter | |
dc.creator.author | Atar, Dan | |
dc.creator.author | Kvien, Tore K | |
dc.identifier.doi | http://dx.doi.org/10.1186/ar2442 | |
dc.identifier.urn | URN:NBN:no-50454 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/46267/1/13075_2008_Article_2292.pdf | |
dc.type.version | PublishedVersion | |
cristin.articleid | R70 | |