Browsing BioMed Central høstingsarkiv by Author "Zetterberg, Henrik"

Now showing items 1-9 of 9

  • APOE ε4 genotype-dependent cerebrospinal fluid proteomic signatures in Alzheimer’s disease 
    Konijnenberg, Elles; Tijms, Betty M; Gobom, Johan; Dobricic, Valerija; Bos, Isabelle; Vos, Stephanie; Tsolaki, Magda; Verhey, Frans; Popp, Julius; Martinez-Lage, Pablo; Vandenberghe, Rik; Lleó, Alberto; Frölich, Lutz; Lovestone, Simon; Streffer, Johannes; Bertram, Lars; Blennow, Kaj; Teunissen, Charlotte E; Veerhuis, Robert; Smit, August B; Scheltens, Philip; Zetterberg, Henrik; Visser, Pieter J (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Background Aggregation of amyloid β into plaques in the brain is one of the earliest pathological events in Alzheimer’s disease (AD). The exact pathophysiology leading to dementia is still uncertain, but the apolipoprotein ...
  • Cerebrospinal fluid tau levels are associated with abnormal neuronal plasticity markers in Alzheimer’s disease 
    Visser, Pieter J.; Reus, Lianne M.; Gobom, Johan; Jansen, Iris; Dicks, Ellen; van der Lee, Sven J.; Tsolaki, Magda; Verhey, Frans R. J.; Popp, Julius; Martinez-Lage, Pablo; Vandenberghe, Rik; Lleó, Alberto; Molinuevo, José L.; Engelborghs, Sebastiaan; Freund-Levi, Yvonne; Froelich, Lutz; Sleegers, Kristel; Dobricic, Valerija; Lovestone, Simon; Streffer, Johannes; Vos, Stephanie J. B.; Bos, Isabelle; Smit, August B.; Blennow, Kaj; Scheltens, Philip; Teunissen, Charlotte E.; Bertram, Lars; Zetterberg, Henrik; Tijms, Betty M. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Background Increased total tau (t-tau) in cerebrospinal fluid (CSF) is a key characteristic of Alzheimer’s disease (AD) and is considered to result from neurodegeneration. T-tau levels, however, can be ...
  • CSF sTREM2 in delirium—relation to Alzheimer’s disease CSF biomarkers Aβ42, t-tau and p-tau 
    Henjum, Kristi; Quist-Paulsen, Else; Zetterberg, Henrik; Blennow, Kaj; Nilsson, Lars N G; Watne, Leiv O (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    Background Delirium and dementia share symptoms of cognitive dysfunctions, and mechanisms of neuroinflammation appear involved in both conditions. Triggering receptor expressed on myeloid cells 2 (TREM2) ...
  • Effects of cerebrovascular disease on amyloid precursor protein metabolites in cerebrospinal fluid 
    Selnes, Per; Blennow, Kaj; Zetterberg, Henrik; Grambaite, Ramune; Rosengren, Lars; Johnsen, Lisbeth; Stenset, Vidar; Fladby, Tormod (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2010)
    Background Alzheimer's disease (AD) and cerebrovascular disease (CVD) including chronic small vessel disease of the brain (SVD) are the most frequent causes of dementia. AD is associated with metabolism ...
  • Heart fatty acid binding protein and Aβ-associated Alzheimer’s neurodegeneration 
    Desikan, Rahul S; Thompson, Wesley K; Holland, Dominic; Hess, Christopher P; Brewer, James B; Zetterberg, Henrik; Blennow, Kaj; Andreassen, Ole A; McEvoy, Linda K; Hyman, Bradley T; Dale, Anders M (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)
    Background Epidemiological and molecular findings suggest a relationship between Alzheimer’s disease (AD) and dyslipidemia, although the nature of this association is not well understood. ...
  • MRI predictors of amyloid pathology: results from the EMIF-AD Multimodal Biomarker Discovery study 
    ten Kate, Mara; Redolfi, Alberto; Peira, Enrico; Bos, Isabelle; Vos, Stephanie J; Vandenberghe, Rik; Gabel, Silvy; Schaeverbeke, Jolien; Scheltens, Philip; Blin, Olivier; Richardson, Jill C; Bordet, Regis; Wallin, Anders; Eckerstrom, Carl; Molinuevo, José L; Engelborghs, Sebastiaan; Van Broeckhoven, Christine; Martinez-Lage, Pablo; Popp, Julius; Tsolaki, Magdalini; Verhey, Frans R J; Baird, Alison L; Legido-Quigley, Cristina; Bertram, Lars; Dobricic, Valerija; Zetterberg, Henrik; Lovestone, Simon; Streffer, Johannes; Bianchetti, Silvia; Novak, Gerald P; Revillard, Jerome; Gordon, Mark F; Xie, Zhiyong; Wottschel, Viktor; Frisoni, Giovanni; Visser, Pieter J; Barkhof, Frederik (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    Background With the shift of research focus towards the pre-dementia stage of Alzheimer’s disease (AD), there is an urgent need for reliable, non-invasive biomarkers to predict amyloid pathology. The aim ...
  • Multivariate GWAS of Alzheimer’s disease CSF biomarker profiles implies GRIN2D in synaptic functioning 
    Neumann, Alexander; Ohlei, Olena; Küçükali, Fahri; Bos, Isabelle J.; Timsina, Jigyasha; Vos, Stephanie; Prokopenko, Dmitry; Tijms, Betty M.; Andreasson, Ulf; Blennow, Kaj; Vandenberghe, Rik; Scheltens, Philip; Teunissen, Charlotte E.; Engelborghs, Sebastiaan; Frisoni, Giovanni B.; Blin, Oliver; Richardson, Jill C.; Bordet, Régis; Lleó, Alberto; Alcolea, Daniel; Popp, Julius; Marsh, Thomas W.; Gorijala, Priyanka; Clark, Christopher; Peyratout, Gwendoline; Martinez-Lage, Pablo; Tainta, Mikel; Dobson, Richard J. B.; Legido-Quigley, Cristina; Van Broeckhoven, Christine; Tanzi, Rudolph E.; ten Kate, Mara; Lill, Christina M.; Barkhof, Frederik; Cruchaga, Carlos; Lovestone, Simon; Streffer, Johannes; Zetterberg, Henrik; Visser, Pieter J.; Sleegers, Kristel; Bertram, Lars (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Background Genome-wide association studies (GWAS) of Alzheimer’s disease (AD) have identified several risk loci, but many remain unknown. Cerebrospinal fluid (CSF) biomarkers may aid in gene discovery and ...
  • Plasma interferon-alpha is associated with double-positivity for autoantibodies but is not a predictor of remission in early rheumatoid arthritis—a spin-off study of the NORD-STAR randomized clinical trial 
    Stockfelt, Marit; Lundell, Anna-Carin; Hetland, Merete L.; Østergaard, Mikkel; Uhlig, Till; Heiberg, Marte S.; Haavardsholm, Espen A.; Nurmohamed, Michael T.; Lampa, Jon; Nordström, Dan; Petersen, Kim H.; Gudbjornsson, Bjorn; Gröndal, Gerdur; Aldridge, Jonathan; Andersson, Kerstin; Blennow, Kaj; Zetterberg, Henrik; van Vollenhoven, Ronald; Rudin, Anna (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    Background The type I interferon (IFN) gene signature is present in a subgroup of patients with early rheumatoid arthritis (RA). Protein levels of IFNα have not been measured in RA and it is unknown whether ...
  • The EMIF-AD Multimodal Biomarker Discovery study: design, methods and cohort characteristics 
    Bos, Isabelle; Vos, Stephanie; Vandenberghe, Rik; Scheltens, Philip; Engelborghs, Sebastiaan; Frisoni, Giovanni; Molinuevo, José L; Wallin, Anders; Lleó, Alberto; Popp, Julius; Martinez-Lage, Pablo; Baird, Alison; Dobson, Richard; Legido-Quigley, Cristina; Sleegers, Kristel; Van Broeckhoven, Christine; Bertram, Lars; ten Kate, Mara; Barkhof, Frederik; Zetterberg, Henrik; Lovestone, Simon; Streffer, Johannes; Visser, Pieter J (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    Background There is an urgent need for novel, noninvasive biomarkers to diagnose Alzheimer’s disease (AD) in the predementia stages and to predict the rate of decline. Therefore, we set up the European ...