Browsing BioMed Central høstingsarkiv by Title

Now showing items 1675-1694 of 3217

  • Lack of association between screening interval and cancer stage in Lynch syndrome may be accounted for by over-diagnosis; a prospective Lynch syndrome database report 
    Seppälä, Toni T; Ahadova, Aysel; Dominguez-Valentin, Mev; Macrae, Finlay; Evans, D. G; Therkildsen, Christina; Sampson, Julian; Scott, Rodney; Burn, John; Möslein, Gabriela; Bernstein, Inge; Holinski-Feder, Elke; Pylvänäinen, Kirsi; Renkonen-Sinisalo, Laura; Lepistö, Anna; Lautrup, Charlotte K; Lindblom, Annika; Plazzer, John-Paul; Winship, Ingrid; Tjandra, Douglas; Katz, Lior H; Aretz, Stefan; Hüneburg, Robert; Holzapfel, Stefanie; Heinimann, Karl; Valle, Adriana D; Neffa, Florencia; Gluck, Nathan; de Vos tot Nederveen Cappel, Wouter H; Vasen, Hans; Morak, Monika; Steinke-Lange, Verena; Engel, Christoph; Rahner, Nils; Schmiegel, Wolff; Vangala, Deepak; Thomas, Huw; Green, Kate; Lalloo, Fiona; Crosbie, Emma J; Hill, James; Capella, Gabriel; Pineda, Marta; Navarro, Matilde; Blanco, Ignacio; ten Broeke, Sanne; Nielsen, Maartje; Ljungmann, Ken; Nakken, Sigve; Lindor, Noralane; Frayling, Ian; Hovig, Eivind; Sunde, Lone; Kloor, Matthias; Mecklin, Jukka-Pekka; Kalager, Mette; Møller, Pål (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    Background Recent epidemiological evidence shows that colorectal cancer (CRC) continues to occur in carriers of pathogenic mismatch repair (path_MMR) variants despite frequent colonoscopy surveillance in ...
  • Lack of association between the chemokine receptor 5 polymorphism CCR5delta32 in rheumatoid arthritis and juvenile idiopathic arthritis 
    Lindner, Ewald; Nordang, Gry B; Melum, Espen; Flatø, Berit; Selvaag, Anne M; Thorsby, Erik; Kvien, Tore K; Førre, Øystein T; Lie, Benedicte A (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2007)
    Background The chemokine receptor CCR5 has been detected at elevated levels on synovial T cells, and a 32 bp deletion in the CCR5 gene leads to a non-functional receptor. A negative association between the ...
  • Lack of exon 10 in the murine tau gene results in mild sensorimotor defects with aging 
    Gumucio, Astrid; Lannfelt, Lars; Nilsson, Lars N (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)
    Background Complex species-specific, developmental- and tissue-dependent mechanisms regulate alternative splicing of tau, thereby diversifying tau protein synthesis. The functional role of alternative ...
  • Lack of informed consent for surgical procedures by elderly patients with inability to consent: a retrospective chart review from an academic medical center in Norway 
    Dahlberg, Jorgen; Dahl, Vegard; Forde, Reidun; Pedersen, Reidar (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    Background Respect for patient autonomy and the requirement of informed consent is an essential basic patient right. It is constituted through international conventions and implemented in health law in ...
  • Lactation and cardiovascular risk factors in mothers in a population-based study: the HUNT-study 
    Natland, Siv T; Nilsen, Tom I L; Midthjell, Kristian; Andersen, Lene F; Forsmo, Siri (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2012)
    Background Lactation has beneficial short term effects on maternal metabolic health, but the long term effects are less well known. Methods We ...
  • Lamina-associated domains: peripheral matters and internal affairs 
    Briand, Nolwenn; Collas, Philippe (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    At the nuclear periphery, associations of chromatin with the nuclear lamina through lamina-associated domains (LADs) aid functional organization of the genome. We review the organization of LADs and provide evidence of LAD ...
  • Laparoscopic and open surgery for pheochromocytoma 
    Edwin, Bjørn; Kazaryan, Airazat M; Mala, Tom; Pfeffer, Per F; Tønnessen, Tor I; Fosse, Erik (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2001)
    Backround Laparoscopic adrenalectomy is a promising alternative to open surgery although concerns exist in regard to laparoscopic treatment of pheocromocytoma. This report compares the outcome of laparoscopic ...
  • Laparoscopic liver resection for non-colorectal non-neuroendocrine metastases: perioperative and oncologic outcomes 
    Aghayan, Davit L; Kalinowski, Piotr; Kazaryan, Airazat M; Fretland, Åsmund A; Sahakyan, Mushegh A; Røsok, Bård I; Pelanis, Egidijus; Bjørnbeth, Bjørn A; Edwin, Bjørn (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    Background Liver resection is a treatment of choice for colorectal and neuroendocrine liver metastases, and laparoscopy is an accepted approach for surgical treatment of these patients. The role of liver ...
  • Laparoscopic versus open surgery for locally advanced and metastatic gastric cancer complicated with bleeding and/or stenosis: short- and long-term outcomes 
    Khorobrykh, Tatyana V.; Abdulkhakimov, Nuriddin M.; Agadzhanov, Vadim G.; Aghayan, Davit L.; Kazaryan, Airazat M. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Background Laparoscopic surgery has justified its efficacy in the treatment of early gastric cancer. There are limited data indicating the eligibility of laparoscopic interventions in locally advanced ...
  • Large and non-specific somatic disease burdens among ageing, long-term opioid maintenance treatment patients 
    Medved, David; Clausen, Thomas; Bukten, Anne; Bjørnestad, Ronny; Muller, Ashley E (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Objectives To describe and explore somatic disease burdens of ageing long-term patients in opioid maintenance treatment (OMT), a unique population emerging in countries offering OMT as a long-term treatment. ...
  • Large-scale inference of the point mutational spectrum in human segmental duplications 
    Nakken, Sigve; Rødland, Einar A; Rognes, Torbjørn; Hovig, Eivind (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2009)
    Background Recent segmental duplications are relatively large (≥ 1 kb) genomic regions of high sequence identity (≥ 90%). They cover approximately 4–5% of the human genome and play important roles in gene ...
  • Large-scale mapping of mutations affecting zebrafish development 
    Geisler, Robert; Rauch, Gerd-Jörg; Geiger-Rudolph, Silke; Albrecht, Andrea; Bebber, Frauke v; Berger, Andrea; Busch-Nentwich, Elisabeth; Dahm, Ralf; Dekens, Marcus P; Dooley, Christopher; Elli, Alexandra F; Gehring, Ines; Geiger, Horst; Geisler, Maria; Glaser, Stefanie; Holley, Scott; Huber, Matthias; Kerr, Andy; Kirn, Anette; Knirsch, Martina; Konantz, Martina; Küchler, Axel M; Maderspacher, Florian; Neuhauss, Stephan C; Nicolson, Teresa; Ober, Elke A; Praeg, Elke; Ray, Russell; Rentzsch, Brit; Rick, Jens M; Rief, Eva; Schauerte, Heike E; Schepp, Carsten P; Schönberger, Ulrike; Schonthaler, Helia B; Seiler, Christoph; Sidi, Samuel; Söllner, Christian; Wehner, Anja; Weiler, Christian; Nüsslein-Volhard, Christiane (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2007)
    Background Large-scale mutagenesis screens in the zebrafish employing the mutagen ENU have isolated several hundred mutant loci that represent putative developmental control genes. In order to realize the ...
  • Lay beliefs of TB and TB/HIV co-infection in Addis Ababa, Ethiopia: a qualitative study 
    Gebremariam, Mekdes K; Bjune, Gunnar A; Frich, Jan C (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
    Background Knowledge about lay beliefs of etiology, transmission and treatment of TB, and lay perceptions of the relationship between TB and HIV is important for understanding patients' health seeking ...
  • Leadership is the essential human factor in the trauma team – results of a qualitative study 
    Hjortdahl, Magnus; Ringen, Amund H; Næss, Anne-Cathrine; Wisborg, Torben (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2009)
  • Leadership, staffing and quality of care in nursing homes 
    Havig, Anders K; Skogstad, Anders; Kjekshus, Lars E; Romøren, Tor I (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
    Background Leadership and staffing are recognised as important factors for quality of care. This study examines the effects of ward leaders' task- and relationship-oriented leadership styles, staffing ...
  • Leading during change: the effects of leader behavior on sickness absence in a Norwegian health trust 
    Bernstrøm, Vilde H; Kjekshus, Lars E (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2012)
    Background Organizational change often leads to negative employee outcomes such as increased absence. Because change is also often inevitable, it is important to know how these negative outcomes could be ...
  • Lean fish consumption is associated with lower risk of metabolic syndrome: a Norwegian cross sectional study 
    Tørris, C.; Molin, M.; Cvancarova, M. S (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
    Background Fish consumption may have a role in reducing the prevalence of metabolic syndrome (MetS). The aim of this study was to identify associations between fish consumption and MetS and its components, ...
  • Leisure time physical activity and the risk of hip or knee replacement due to primary osteoarthritis: a population based cohort study (The HUNT Study) 
    Johnsen, Marianne B; Hellevik, Alf I; Baste, Valborg; Furnes, Ove; Langhammer, Arnulf; Flugsrud, Gunnar; Nordsletten, Lars; Zwart, John A; Storheim, Kjersti (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
    Background The relationship between leisure time physical activity (LPA) and hip and knee OA and subsequent joint replacement has not yet been clearly defined. Some studies have found the risk of knee ...
  • Leptin and adiponectin as predictors of cardiovascular risk after gestational diabetes mellitus 
    Lekva, Tove; Michelsen, Annika E; Aukrust, Pål; Henriksen, Tore; Bollerslev, Jens; Ueland, Thor (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
    Background Gestational diabetes mellitus (GDM) is a significant risk factor for cardiovascular disease (CVD) in later life, but the mechanism remains unclear. Adipokine imbalance in the presence of metabolic ...
  • Lessons learned from implementing a responsive quality assessment of clinical ethics support 
    van Baarle, Eva M; Potma, Marieke C; van Hoek, Maria E C; Hartman, Laura A; Molewijk, Bert A C; van Gurp, Jelle L P (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    Background Various forms of Clinical Ethics Support (CES) have been developed in health care organizations. Over the past years, increasing attention has been paid to the question of how to foster the quality ...