Functional / dissociative seizures: Epidemiological and clinical aspects
Sammendrag
Patients with functional/dissociative seizures (FDS) are commonly seen in neurological practice. FDS is a functional neurological disorder and associated with high rates of disability and economic stagnation. The articles included in this thesis provided, to the best of our knowledge, the first population-based estimates of the prevalence of FDS in a particular population. The highest prevalence was found in adolescents. In a prospective cohort study from the National Center for Epilepsy, the long-term prognosis of FDS was poor. At follow-up (mean duration of almost 6 years), 61% of patients diagnosed with FDS continued to experience seizures. We found that attachment anxiety, female gender, and self-rated executive dysfunction were risk factors for persistent FDS. Knowledge about the occurrence, long-term outcomes, and risk factors for the persistence of FDS are important both for the patients and the clinicians involved with this patient group, as well as for planning of healthcare services.Artikkelliste
Paper I. Villagrán A, Eldøen G, Duncan R, Aaberg KM, Hofoss D, Lossius MI. Incidence and prevalence of psychogenic nonepileptic seizures in a Norwegian county: A 10-year population-based study. Epilepsia. 2021 Jul; 62(7):1528-1535. DOI: 10.1111/epi.16949. The article is included in the thesis. Also available at: https://doi.org/10.1111/epi.16949 |
Paper II. Villagrán A, Lund C, Duncan R, Lossius MI. The effect of attachment style on long-term outcomes in psychogenic nonepileptic seizures: results from a prospective study. Epilepsy Behav 2022; 135:108890. DOI: 10.1016/j.yebeh.2022.108890. The article is included in the thesis. Also available at: https://doi.org/10.1016/j.yebeh.2022.108890 |
Paper III. Villagrán A, Lund C, Duncan R, Ingvar Lossius M. Adverse life events in patients with functional seizures: Assessment in clinical practice and association with long-term outcome. Epilepsy Behav. 2023 Oct 5;148:109456. DOI: 10.1016/j.yebeh.2023.109456. The article is included in the thesis. Also available at: https://doi.org/10.1016/j.yebeh.2023.109456 |
Paper IV. Villagrán A, Hessen E, Torgersen H, Alfstad KÅ, Lossius MI. Negative impact of self-reported executive problems on the long-term outcome in patients with functional/dissociative seizures: results from a prospective observational study. In preparation. To be published. The paper is not available in DUO awaiting publishing. |