dc.contributor.author | Solbakken, Siri M. | |
dc.contributor.author | Meyer, Haakon E. | |
dc.contributor.author | Dahl, Cecilie | |
dc.contributor.author | Finnes, Trine E. | |
dc.contributor.author | Hjellvik, Vidar | |
dc.contributor.author | Nielsen, Christopher S. | |
dc.contributor.author | Omsland, Tone K. | |
dc.contributor.author | Stigum, Hein | |
dc.contributor.author | Holvik, Kristin | |
dc.date.accessioned | 2024-03-19T06:49:42Z | |
dc.date.available | 2024-03-19T06:49:42Z | |
dc.date.issued | 2024 | |
dc.identifier.citation | BMC Medicine. 2024 Mar 13;22(1):118 | |
dc.identifier.uri | http://hdl.handle.net/10852/109819 | |
dc.description.abstract | Background
Few previous studies have assessed overall morbidity at the individual level with respect to future risk of hip fracture. The aim of this register-based cohort study was to examine the association between morbidity measured by the medication-based Rx-Risk Comorbidity Index (Rx-Risk) and the risk of first hip fracture.
Methods
Individual-level data on medications dispensed from pharmacies (2005–2016) was retrieved from the Norwegian Prescription Database and used to calculate Rx-Risk for each calendar year. Information on first hip fractures (2006–2017) was obtained from a nationwide hip fracture database. Individuals ≥ 51 years who filled at least one prescription during the study period comprised the population at risk. Using Rx-Risk as a time-varying exposure variable, relative risk estimates were obtained by a negative binomial model.
Results
During 2006–2017, 94,104 individuals sustained a first hip fracture. A higher Rx-Risk was associated with increased risk of hip fracture within all categories of age and sex. Women with the highest Rx-Risk (> 25) had a relative risk of 6.1 (95% confidence interval (CI): 5.4, 6.8) compared to women with Rx-Risk ≤ 0, whereas the corresponding relative risk in women with Rx-Risk 1–5 was 1.4 (95% CI: 1.3, 1.4). Similar results were found in men. Women > 80 years with Rx-Risk 21–25 had the highest incidence rate (514 (95% CI: 462, 566) per 10, 000 person years). The relative increase in hip fracture risk with higher Rx-Risk was most pronounced in the youngest patients aged 51–65 years.
Conclusions
Rx-Risk is a strong predictor of hip fracture in the general outpatient population and may be useful to identify individuals at risk in a clinical setting and in future studies. | |
dc.language.iso | eng | |
dc.rights | The Author(s) | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.title | The medication-based Rx-Risk Comorbidity Index and risk of hip fracture - a nationwide NOREPOS cohort study | |
dc.type | Journal article | |
dc.date.updated | 2024-03-19T06:49:43Z | |
dc.creator.author | Solbakken, Siri M. | |
dc.creator.author | Meyer, Haakon E. | |
dc.creator.author | Dahl, Cecilie | |
dc.creator.author | Finnes, Trine E. | |
dc.creator.author | Hjellvik, Vidar | |
dc.creator.author | Nielsen, Christopher S. | |
dc.creator.author | Omsland, Tone K. | |
dc.creator.author | Stigum, Hein | |
dc.creator.author | Holvik, Kristin | |
dc.identifier.cristin | 2254729 | |
dc.identifier.doi | https://doi.org/10.1186/s12916-024-03335-w | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.type.version | PublishedVersion | |
cristin.articleid | 118 | |