dc.date.accessioned | 2023-02-09T18:13:15Z | |
dc.date.available | 2023-02-09T18:13:15Z | |
dc.date.created | 2022-04-27T12:49:41Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Eagles, David A. Saez, Natalie J. Krishnarjuna, Bankala Bradford, Julia J. Chin, Yanni K.-Y. Starobova, Hana Mueller, Alexander Reichelt, Melissa E. Undheim, Eivind Andreas Baste Norton, Raymond S. Thomas, Walter G. Vetter, Irina King, Glenn F. Robinson, Samuel D. . A peptide toxin in ant venom mimics vertebrate EGF-like hormones to cause long-lasting hypersensitivity in mammals. Proceedings of the National Academy of Sciences of the United States of America. 2022, 119(7) | |
dc.identifier.uri | http://hdl.handle.net/10852/99853 | |
dc.description.abstract | Significance
The targeting of mammalian ErbB receptor signaling by a venom toxin to cause hypersensitivity is a mode of action that has not previously been described. Natural selection of a defensive toxin to target ErbB signaling provides compelling independent evidence for a fundamental role of this receptor and its ligands in mammalian pain. The evolution of a toxin in ant venom to mimic a vertebrate nociceptive hormone serves as an example of both convergent evolution and molecular mimicry, illustrating how natural selection can shape the gene product of one organism to resemble that of another. | |
dc.language | EN | |
dc.publisher | The National Academy of Sciences | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.title | A peptide toxin in ant venom mimics vertebrate EGF-like hormones to cause long-lasting hypersensitivity in mammals | |
dc.title.alternative | ENEngelskEnglishA peptide toxin in ant venom mimics vertebrate EGF-like hormones to cause long-lasting hypersensitivity in mammals | |
dc.type | Journal article | |
dc.creator.author | Eagles, David A. | |
dc.creator.author | Saez, Natalie J. | |
dc.creator.author | Krishnarjuna, Bankala | |
dc.creator.author | Bradford, Julia J. | |
dc.creator.author | Chin, Yanni K.-Y. | |
dc.creator.author | Starobova, Hana | |
dc.creator.author | Mueller, Alexander | |
dc.creator.author | Reichelt, Melissa E. | |
dc.creator.author | Undheim, Eivind Andreas Baste | |
dc.creator.author | Norton, Raymond S. | |
dc.creator.author | Thomas, Walter G. | |
dc.creator.author | Vetter, Irina | |
dc.creator.author | King, Glenn F. | |
dc.creator.author | Robinson, Samuel D. | |
cristin.unitcode | 185,15,29,0 | |
cristin.unitname | Institutt for biovitenskap | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |
dc.identifier.cristin | 2019495 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Proceedings of the National Academy of Sciences of the United States of America&rft.volume=119&rft.spage=&rft.date=2022 | |
dc.identifier.jtitle | Proceedings of the National Academy of Sciences of the United States of America | |
dc.identifier.volume | 119 | |
dc.identifier.issue | 7 | |
dc.identifier.pagecount | 9 | |
dc.identifier.doi | https://doi.org/10.1073/pnas.2112630119 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 0027-8424 | |
dc.type.version | PublishedVersion | |
dc.relation.project | NFR/287462 | |