dc.date.accessioned | 2023-02-02T16:32:45Z | |
dc.date.available | 2023-02-02T16:32:45Z | |
dc.date.created | 2023-01-27T15:47:14Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Ihler, Henrik Myhre Lyngstad, Siv Hege Gardsjord, Erlend Strand Widing, Line Hustad Flaaten, Camilla Bärthel Åsbø, Gina Wold, Kristin Fjelnseth Engen, Magnus Johan Simonsen, Carmen Elisabeth Ueland, Torill Lagerberg, Trine Vik Melle, Ingrid Romm, Kristin Lie . The trajectory of two negative symptom dimensions in first-episode psychosis and the role of cannabis use: a 10-year follow-up study. Schizophrenia Research. 2023, 252, 317-325 | |
dc.identifier.uri | http://hdl.handle.net/10852/99596 | |
dc.description.abstract | Objective
To investigate the trajectories of diminished expression and apathy over 10 years. Further, to explore the effects of baseline- and persistent cannabis use on the development of diminished expression and apathy during follow-up, while controlling other potential sources and predictors of secondary negative symptoms.
Methods
351 participants with a first episode of non-affective psychosis were examined at baseline and invited to follow-up at one year and 10 years. The trajectories of diminished expression and apathy were investigated using linear mixed models. Subsequently, cannabis use and other potential predictors and sources of secondary negative symptoms were added to the model to investigate the respective impact on their trajectories.
Results
The severity of both diminished expression and apathy decreased during the follow-up period after the first episode of psychosis, with the most improvement observed from baseline to 1-year follow-up. Cannabis use at baseline was associated with a long-lasting higher symptom load for diminished expression, but not apathy. Introducing persistent cannabis use to the model further strengthened the association with diminished expression.
Conclusion
Both cannabis use at baseline and persistent cannabis use after a first episode of psychosis were associated with more severe symptoms of diminished expression. Our results imply a causal relationship between cannabis use and diminished expression and suggest that measures to reduce cannabis use both before and after psychosis onset may reduce expressive negative symptoms. | |
dc.language | EN | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | The trajectory of two negative symptom dimensions in first-episode psychosis and the role of cannabis use: a 10-year follow-up study | |
dc.title.alternative | ENEngelskEnglishThe trajectory of two negative symptom dimensions in first-episode psychosis and the role of cannabis use: a 10-year follow-up study | |
dc.type | Journal article | |
dc.creator.author | Ihler, Henrik Myhre | |
dc.creator.author | Lyngstad, Siv Hege | |
dc.creator.author | Gardsjord, Erlend Strand | |
dc.creator.author | Widing, Line Hustad | |
dc.creator.author | Flaaten, Camilla Bärthel | |
dc.creator.author | Åsbø, Gina | |
dc.creator.author | Wold, Kristin Fjelnseth | |
dc.creator.author | Engen, Magnus Johan | |
dc.creator.author | Simonsen, Carmen Elisabeth | |
dc.creator.author | Ueland, Torill | |
dc.creator.author | Lagerberg, Trine Vik | |
dc.creator.author | Melle, Ingrid | |
dc.creator.author | Romm, Kristin Lie | |
cristin.unitcode | 185,53,10,70 | |
cristin.unitname | NORMENT part UiO | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |
dc.identifier.cristin | 2116875 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Schizophrenia Research&rft.volume=252&rft.spage=317&rft.date=2023 | |
dc.identifier.jtitle | Schizophrenia Research | |
dc.identifier.volume | 252 | |
dc.identifier.startpage | 317 | |
dc.identifier.endpage | 325 | |
dc.identifier.doi | https://doi.org/10.1016/j.schres.2023.01.024 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 0920-9964 | |
dc.type.version | PublishedVersion | |