dc.date.accessioned | 2023-01-30T17:50:41Z | |
dc.date.available | 2023-01-30T17:50:41Z | |
dc.date.created | 2022-10-04T13:12:48Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Guslund, Naomi Croft Krabberød, Anders Kristian Nørstebø, Simen Foyn Solbakken, Monica Hongrø Jakobsen, Kjetill Sigurd Johansen, Finn-Eirik Qiao, Shuo-Wang . Lymphocyte subsets in Atlantic cod (Gadus morhua) interrogated by single-cell sequencing. Communications Biology. 2022, 5(1) | |
dc.identifier.uri | http://hdl.handle.net/10852/99445 | |
dc.description.abstract | Abstract Atlantic Cod ( Gadus morhua ) has lost the major histocompatibility complex class II presentation pathway. We recently identified CD8-positive T cells, B cells, and plasma cells in cod, but further characterisation of lymphocyte subsets is needed to elucidate immune adaptations triggered by the absence of CD4-positive T lymphocytes. Here, we use single-cell RNA sequencing to examine the lymphocyte heterogeneity in Atlantic cod spleen. We describe five T cell subsets and eight B cell subsets and propose a B cell trajectory of differentiation. Notably, we identify a subpopulation of T cells that are CD8-negative. Most of the CD8-negative T lymphocytes highly express the homologue of monocyte chemotactic protein 1b , and another subset of CD8-negative T lymphocytes express the homologue of the scavenger receptor m130 . Uncovering the multiple lymphocyte cell sub-clusters reveals the different immune states present within the B and T cell populations, building a foundation for further work. | |
dc.language | EN | |
dc.publisher | Nature Portfolio | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | Lymphocyte subsets in Atlantic cod (Gadus morhua) interrogated by single-cell sequencing | |
dc.title.alternative | ENEngelskEnglishLymphocyte subsets in Atlantic cod (Gadus morhua) interrogated by single-cell sequencing | |
dc.type | Journal article | |
dc.creator.author | Guslund, Naomi Croft | |
dc.creator.author | Krabberød, Anders Kristian | |
dc.creator.author | Nørstebø, Simen Foyn | |
dc.creator.author | Solbakken, Monica Hongrø | |
dc.creator.author | Jakobsen, Kjetill Sigurd | |
dc.creator.author | Johansen, Finn-Eirik | |
dc.creator.author | Qiao, Shuo-Wang | |
cristin.unitcode | 185,53,18,12 | |
cristin.unitname | Avdeling for immunologi og transfusjonsmedisin | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 2058387 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Communications Biology&rft.volume=5&rft.spage=&rft.date=2022 | |
dc.identifier.jtitle | Communications Biology | |
dc.identifier.volume | 5 | |
dc.identifier.issue | 1 | |
dc.identifier.pagecount | 9 | |
dc.identifier.doi | https://doi.org/10.1038/s42003-022-03645-w | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 2399-3642 | |
dc.type.version | PublishedVersion | |
cristin.articleid | 689 | |
dc.relation.project | NFR/301965 | |