Identification of trypsin-degrading commensals in the large intestine
dc.date.accessioned | 2023-01-25T18:19:10Z | |
dc.date.available | 2023-01-25T18:19:10Z | |
dc.date.created | 2022-11-11T08:05:32Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Li, Youxian Watanabe, Eiichiro Kawashima, Yusuke Plichta, Damian R. Wang, Zhujun Ujike, Makoto Ang, Qi Yan Wu, Runrun Furuichi, Munehiro Takeshita, Kozue Yoshida, Koji Nishiyama, Keita Kearney, Sean M. Suda, Wataru Hattori, Masahira Sasajima, Satoshi Matsunaga, Takahiro Zhang, Xiaoxi Watanabe, Kazuto Fujishiro, Jun Norman, Jason M. Olle, Bernat Matsuyama, Shutoku Namkoong, Ho Uwamino, Yoshifumi Ishii, Makoto Fukunaga, Koichi Hasegawa, Naoki Ohara, Osamu Xavier, Ramnik J. Atarashi, Koji Honda, Kenya . Identification of trypsin-degrading commensals in the large intestine. Nature. 2022, 609(7927), 582-589 | |
dc.identifier.uri | http://hdl.handle.net/10852/99193 | |
dc.description.abstract | Abstract Increased levels of proteases, such as trypsin, in the distal intestine have been implicated in intestinal pathological conditions 1–3 . However, the players and mechanisms that underlie protease regulation in the intestinal lumen have remained unclear. Here we show that Paraprevotella strains isolated from the faecal microbiome of healthy human donors are potent trypsin-degrading commensals. Mechanistically, Paraprevotella recruit trypsin to the bacterial surface through type IX secretion system-dependent polysaccharide-anchoring proteins to promote trypsin autolysis. Paraprevotella colonization protects IgA from trypsin degradation and enhances the effectiveness of oral vaccines against Citrobacter rodentium . Moreover, Paraprevotella colonization inhibits lethal infection with murine hepatitis virus-2, a mouse coronavirus that is dependent on trypsin and trypsin-like proteases for entry into host cells 4,5 . Consistently, carriage of putative genes involved in trypsin degradation in the gut microbiome was associated with reduced severity of diarrhoea in patients with SARS-CoV-2 infection. Thus, trypsin-degrading commensal colonization may contribute to the maintenance of intestinal homeostasis and protection from pathogen infection. | |
dc.language | EN | |
dc.publisher | Nature Portfolio | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | Identification of trypsin-degrading commensals in the large intestine | |
dc.title.alternative | ENEngelskEnglishIdentification of trypsin-degrading commensals in the large intestine | |
dc.type | Journal article | |
dc.creator.author | Li, Youxian | |
dc.creator.author | Watanabe, Eiichiro | |
dc.creator.author | Kawashima, Yusuke | |
dc.creator.author | Plichta, Damian R. | |
dc.creator.author | Wang, Zhujun | |
dc.creator.author | Ujike, Makoto | |
dc.creator.author | Ang, Qi Yan | |
dc.creator.author | Wu, Runrun | |
dc.creator.author | Furuichi, Munehiro | |
dc.creator.author | Takeshita, Kozue | |
dc.creator.author | Yoshida, Koji | |
dc.creator.author | Nishiyama, Keita | |
dc.creator.author | Kearney, Sean M. | |
dc.creator.author | Suda, Wataru | |
dc.creator.author | Hattori, Masahira | |
dc.creator.author | Sasajima, Satoshi | |
dc.creator.author | Matsunaga, Takahiro | |
dc.creator.author | Zhang, Xiaoxi | |
dc.creator.author | Watanabe, Kazuto | |
dc.creator.author | Fujishiro, Jun | |
dc.creator.author | Norman, Jason M. | |
dc.creator.author | Olle, Bernat | |
dc.creator.author | Matsuyama, Shutoku | |
dc.creator.author | Namkoong, Ho | |
dc.creator.author | Uwamino, Yoshifumi | |
dc.creator.author | Ishii, Makoto | |
dc.creator.author | Fukunaga, Koichi | |
dc.creator.author | Hasegawa, Naoki | |
dc.creator.author | Ohara, Osamu | |
dc.creator.author | Xavier, Ramnik J. | |
dc.creator.author | Atarashi, Koji | |
dc.creator.author | Honda, Kenya | |
cristin.unitcode | 185,53,49,12 | |
cristin.unitname | Institutt for kreftforskning | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |
dc.identifier.cristin | 2072192 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nature&rft.volume=609&rft.spage=582&rft.date=2022 | |
dc.identifier.jtitle | Nature | |
dc.identifier.volume | 609 | |
dc.identifier.issue | 7927 | |
dc.identifier.startpage | 582 | |
dc.identifier.endpage | 589 | |
dc.identifier.doi | https://doi.org/10.1038/s41586-022-05181-3 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 0028-0836 | |
dc.type.version | PublishedVersion |
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