dc.date.accessioned | 2023-01-22T16:09:25Z | |
dc.date.available | 2023-01-22T16:09:25Z | |
dc.date.created | 2022-10-13T09:35:08Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Brunvoll, Sonja Hjellegjerde Nygaard, Anders Benteson Ellingjord-Dale, Merete Holland, Petter Istre, Mette Stausland Kalleberg, Karl Trygve Søraas, Camilla Lund Holven, Kirsten Bjørklund Ulven, Stine Marie Hjartåker, Anette Haider, Trond Lund-Johansen, Fridtjof Dahl, John Arne Meyer, Haakon Eduard Søraas, Arne Vasli . Prevention of covid-19 and other acute respiratory infections with cod liver oil supplementation, a low dose vitamin D supplement: quadruple blinded, randomised placebo controlled trial. The BMJ. 2022, 378 | |
dc.identifier.uri | http://hdl.handle.net/10852/99079 | |
dc.description.abstract | Objective To determine if daily supplementation with cod liver oil, a low dose vitamin D supplement, in winter, prevents SARS-CoV-2 infection, serious covid-19, or other acute respiratory infections in adults in Norway. Design Quadruple blinded, randomised placebo controlled trial. Setting Norway, 10 November 2020 to 2 June 2021. Participants 34601 adults (aged 18-75 years), not taking daily vitamin D supplements. Intervention 5 mL/day of cod liver oil (10 µg of vitamin D, n=17278) or placebo (n=17323) for up to six months. Main outcome measures Four co-primary endpoints were predefined: the first was a positive SARS-CoV-2 test result determined by reverse transcriptase-quantitative polymerase chain reaction and the second was serious covid-19, defined as self-reported dyspnoea, admission to hospital, or death. Other acute respiratory infections were indicated by the third and fourth co-primary endpoints: a negative SARS-CoV-2 test result and self-reported symptoms. Side effects related to the supplementation were self-reported. The fallback method was used to handle multiple comparisons. Results Supplementation with cod liver oil was not associated with a reduced risk of any of the co-primary endpoints. Participants took the supplement (cod liver oil or placebo) for a median of 164 days, and 227 (1.31%) participants in the cod liver oil group and 228 (1.32%) participants in the placebo group had a positive SARS-CoV-2 test result (relative risk 1.00, multiple comparison adjusted confidence interval 0.82 to 1.22). Serious covid-19 was identified in 121 (0.70%) participants in the cod liver oil group and in 101 (0.58%) participants in the placebo group (1.20, 0.87 to 1.65). 8546 (49.46%) and 8565 (49.44%) participants in the cod liver oil and placebo groups, respectively, had ≥1 negative SARS-CoV-2 test results (1.00, 0.97 to 1.04). 3964 (22.94%) and 3834 (22.13%) participants in the cod liver oil and placebo groups, respectively, reported ≥1 acute respiratory infections (1.04, 0.97 to 1.11). Only low grade side effects were reported in the cod liver oil and placebo groups. Co nclusion Supplementation with cod liver oil in the winter did not reduce the incidence of SARS-CoV-2 infection, serious covid-19, or other acute respiratory infections compared with placebo. Trial registration ClinicalTrials.gov NCT04609423. | |
dc.description.abstract | Prevention of covid-19 and other acute respiratory infections with cod liver oil supplementation, a low dose vitamin D supplement: quadruple blinded, randomised placebo controlled trial | |
dc.language | EN | |
dc.publisher | BMJ Pub. Group | |
dc.rights | Attribution-NonCommercial 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | |
dc.title | Prevention of covid-19 and other acute respiratory infections with cod liver oil supplementation, a low dose vitamin D supplement: quadruple blinded, randomised placebo controlled trial | |
dc.title.alternative | ENEngelskEnglishPrevention of covid-19 and other acute respiratory infections with cod liver oil supplementation, a low dose vitamin D supplement: quadruple blinded, randomised placebo controlled trial | |
dc.type | Journal article | |
dc.creator.author | Brunvoll, Sonja Hjellegjerde | |
dc.creator.author | Nygaard, Anders Benteson | |
dc.creator.author | Ellingjord-Dale, Merete | |
dc.creator.author | Holland, Petter | |
dc.creator.author | Istre, Mette Stausland | |
dc.creator.author | Kalleberg, Karl Trygve | |
dc.creator.author | Søraas, Camilla Lund | |
dc.creator.author | Holven, Kirsten Bjørklund | |
dc.creator.author | Ulven, Stine Marie | |
dc.creator.author | Hjartåker, Anette | |
dc.creator.author | Haider, Trond | |
dc.creator.author | Lund-Johansen, Fridtjof | |
dc.creator.author | Dahl, John Arne | |
dc.creator.author | Meyer, Haakon Eduard | |
dc.creator.author | Søraas, Arne Vasli | |
cristin.unitcode | 185,51,13,20 | |
cristin.unitname | Seksjon for klinisk ernæring | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |
dc.identifier.cristin | 2061030 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=The BMJ&rft.volume=378&rft.spage=&rft.date=2022 | |
dc.identifier.jtitle | The BMJ | |
dc.identifier.volume | 378 | |
dc.identifier.pagecount | 10 | |
dc.identifier.doi | https://doi.org/10.1136/bmj-2022-071245 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 1756-1833 | |
dc.type.version | PublishedVersion | |
cristin.articleid | e071245 | |