dc.date.accessioned | 2023-01-22T16:08:01Z | |
dc.date.available | 2023-03-07T23:45:54Z | |
dc.date.created | 2022-09-14T12:31:20Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Kværner, Ane Sørlie Birkeland, Einar Elvbakken Vinberg, Elina Hoff, Geir Hjartåker, Anette Rounge, Trine Ballestad Berstad, Paula . Associations of red and processed meat intake with screen-detected colorectal lesions. British Journal of Nutrition. 2022, 1-36 | |
dc.identifier.uri | http://hdl.handle.net/10852/99078 | |
dc.description.abstract | Limited data exist regarding the role of meat consumption in early-stage colorectal carcinogenesis. We examined associations of red and processed meat intake with screen-detected colorectal lesions in immunochemical fecal occult blood test (FIT)-positive participants, enrolled in the Norwegian CRCbiome study during 2017-2021, aged 55-77 years. Absolute and energy-adjusted intakes of red and processed meat (combined and individually) were assessed using a validated, semiquantitative food frequency questionnaire. Associations between meat intake and screen-detected colorectal lesions were examined using multinomial logistic regression analyses with adjustment for key covariates. Of 1,162 participants with available dietary data, 319 (27%) presented with advanced colorectal lesions at colonoscopy. High vs low energy-adjusted intakes of red and processed meat combined, as well as red meat alone, were borderline to significantly positively associated with advanced colorectal lesions (ORs (95% CIs) of 1.24 (0.98, 1.57) and 1.34 (1.07, 1.69), respectively). A significant dose-response-relationship was also observed for absolute intake levels (OR (95% CI) of 1.32 (1.09, 1.60) per 100 g/day increase in red and processed meat). For processed meat, no association was observed between energy-adjusted intakes and advanced colorectal lesions. A significant positive association was, however, observed for the small proportion of participants (10%) with absolute intake levels ≥100 vs <50 g/day (OR (95% CI) of 1.19 (1.09, 1.31)). In summary, high intakes of red and processed meat were associated with presence of advanced colorectal lesions at colonoscopy in FIT-positive participants. The study demonstrates a potential role of using dietary data to improve the performance of FIT-based screening. | |
dc.description.abstract | Associations of red and processed meat intake with screen-detected colorectal lesions | |
dc.language | EN | |
dc.title | Associations of red and processed meat intake with screen-detected colorectal lesions | |
dc.title.alternative | ENEngelskEnglishAssociations of red and processed meat intake with screen-detected colorectal lesions | |
dc.type | Journal article | |
dc.creator.author | Kværner, Ane Sørlie | |
dc.creator.author | Birkeland, Einar Elvbakken | |
dc.creator.author | Vinberg, Elina | |
dc.creator.author | Hoff, Geir | |
dc.creator.author | Hjartåker, Anette | |
dc.creator.author | Rounge, Trine Ballestad | |
dc.creator.author | Berstad, Paula | |
cristin.unitcode | 185,51,13,30 | |
cristin.unitname | Seksjon for ernæringsepidemiologi | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |
dc.identifier.cristin | 2051605 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=British Journal of Nutrition&rft.volume=&rft.spage=1&rft.date=2022 | |
dc.identifier.jtitle | British Journal of Nutrition | |
dc.identifier.startpage | 1 | |
dc.identifier.endpage | 36 | |
dc.identifier.doi | https://doi.org/10.1017/S0007114522002860 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 0007-1145 | |
dc.type.version | AcceptedVersion | |