dc.date.accessioned | 2023-01-20T17:53:41Z | |
dc.date.available | 2023-01-20T17:53:41Z | |
dc.date.created | 2022-06-19T11:22:34Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Fu, Yu-Ping Li, Cen-Yu Peng, Xi Zou, Yuan-Feng Rise, Frode Paulsen, Berit Smestad Wangensteen, Helle Inngjerdingen, Kari Tvete . Polysaccharides from Aconitum carmichaelii leaves: Structure, immunomodulatory and anti-inflammatory activities. Carbohydrate Polymers. 2022, 291 | |
dc.identifier.uri | http://hdl.handle.net/10852/99006 | |
dc.description.abstract | Roots of Aconitum carmichaelii are used in Asian countries due to its content of bioactive alkaloids. In the production of root preparations, tons of leaves are usually discarded, leading to a huge waste of herbal material. The aim of this study is to investigate the polysaccharides in these unutilized leaves. A neutral polysaccharide (AL-N) appeared to be a mixture of heteromannans, and two purified acidic polysaccharides (AL-I-I and AL-I-II) were shown to be pectins containing a homogalacturonan backbone substituted with terminal β-Xylp-units. AL-I-I consisted of a type-I rhamnogalacturonan core, with arabinan and type-II arabinogalactan domains while AL-I-II was less branched. AL-N and AL-I-I were able to modulate the complement system, while AL-I-II was inactive. Interestingly, AL-N, AL-I-I and AL-I-II were shown to exert anti-inflammatory effects on porcine enterocyte IPEC-J2 cells. AL-I-I and AL-I-II were able to down-regulate the expression of toll-like receptor 4 (TLR4) and nucleotide-binding oligomerization domain 1 (NOD1). | |
dc.language | EN | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | Polysaccharides from Aconitum carmichaelii leaves: Structure, immunomodulatory and anti-inflammatory activities | |
dc.title.alternative | ENEngelskEnglishPolysaccharides from Aconitum carmichaelii leaves: Structure, immunomodulatory and anti-inflammatory activities | |
dc.type | Journal article | |
dc.creator.author | Fu, Yu-Ping | |
dc.creator.author | Li, Cen-Yu | |
dc.creator.author | Peng, Xi | |
dc.creator.author | Zou, Yuan-Feng | |
dc.creator.author | Rise, Frode | |
dc.creator.author | Paulsen, Berit Smestad | |
dc.creator.author | Wangensteen, Helle | |
dc.creator.author | Inngjerdingen, Kari Tvete | |
cristin.unitcode | 185,15,23,0 | |
cristin.unitname | Farmasøytisk institutt | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 2033150 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Carbohydrate Polymers&rft.volume=291&rft.spage=&rft.date=2022 | |
dc.identifier.jtitle | Carbohydrate Polymers | |
dc.identifier.volume | 291 | |
dc.identifier.doi | https://doi.org/10.1016/j.carbpol.2022.119655 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 0144-8617 | |
dc.type.version | PublishedVersion | |
cristin.articleid | 119655 | |