dc.date.accessioned | 2023-01-18T17:55:05Z | |
dc.date.available | 2023-01-18T17:55:05Z | |
dc.date.created | 2022-12-01T14:20:58Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Lyngbakken, Magnus Nakrem Rønningen, Peter Selmer Solberg, Magnar Gangås Berge, Trygve Brynildsen, Jon Aagaard, Erika Nerdrum Kvisvik, Brede Alexander Havneraas Røsjø, Helge Rørvik Steine, Kjetil Tveit, Arnljot Omland, Torbjørn . Prediction of incident atrial fibrillation with cardiac biomarkers and left atrial volumes. Heart. 2022 | |
dc.identifier.uri | http://hdl.handle.net/10852/98914 | |
dc.description.abstract | Objective Atrial fibrillation is a common arrhythmia associated with risk of stroke, heart failure and death. We aimed to elucidate the associations of cardiac biomarkers, echocardiographic left atrial volumetric indices and risk of prevalent and incident atrial fibrillation in the general population. Methods We assessed cardiac troponin T (cTnT), N-terminal pro-B-type natriuretic peptide (NT-proBNP), growth differentiation factor 15 (GDF-15), maximum (LAVi max ) and minimum (LAVi min ) indexed left atrial volumes and left atrial emptying fraction (LAEF) in subjects born in 1950 participating in the prospective observational cohort, Akershus Cardiac Examination 1950 Study. The Cohorts for Heart and Ageing Research in Genomic Epidemiology for Atrial Fibrillation risk score and sex was used to adjust for residual risk of atrial fibrillation. Results Out of 3487 subjects, 157 (4.5%) had prevalent and 123 (3.5%) had incident atrial fibrillation. Echocardiographic left atrial volumes and cardiac biomarkers associated with prevalent atrial fibrillation, but GDF-15 was non-significant in adjusted analysis. Incident atrial fibrillation was predicted by LAVi max (adjusted HR 1.51, 95% CI 1.30 to 1.75), LAVi min (adjusted HR 1.52, 95% CI 1.35 to 1.72), LAEF (adjusted HR 1.24, 95% CI 1.04 to 1.48) and NT-proBNP (adjusted HR 1.57, 95% CI 1.32 to 1.85). cTnT and NT-proBNP provided incremental prognostic information to left atrial volumes, but GDF-15 demonstrated no prognostic value for incident atrial fibrillation. Conclusions In the general population, echocardiographic left atrial volumetric indices and NT-proBNP, but not cTnT and GDF-15, associate with prevalent atrial fibrillation and with risk of incident atrial fibrillation. cTnT and NT-proBNP provide incremental prognostic information to echocardiography. | |
dc.language | EN | |
dc.publisher | BMJ Publishing Group | |
dc.rights | Attribution-NonCommercial 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | |
dc.title | Prediction of incident atrial fibrillation with cardiac biomarkers and left atrial volumes | |
dc.title.alternative | ENEngelskEnglishPrediction of incident atrial fibrillation with cardiac biomarkers and left atrial volumes | |
dc.type | Journal article | |
dc.creator.author | Lyngbakken, Magnus Nakrem | |
dc.creator.author | Rønningen, Peter Selmer | |
dc.creator.author | Solberg, Magnar Gangås | |
dc.creator.author | Berge, Trygve | |
dc.creator.author | Brynildsen, Jon | |
dc.creator.author | Aagaard, Erika Nerdrum | |
dc.creator.author | Kvisvik, Brede Alexander Havneraas | |
dc.creator.author | Røsjø, Helge Rørvik | |
dc.creator.author | Steine, Kjetil | |
dc.creator.author | Tveit, Arnljot | |
dc.creator.author | Omland, Torbjørn | |
cristin.unitcode | 185,53,82,0 | |
cristin.unitname | Klinikk for indremedisin og lab fag | |
cristin.ispublished | true | |
cristin.fulltext | postprint | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 2087178 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Heart&rft.volume=&rft.spage=&rft.date=2022 | |
dc.identifier.jtitle | Heart | |
dc.identifier.startpage | heartjnl-2022 | |
dc.identifier.endpage | 2022-321608 | |
dc.identifier.pagecount | 0 | |
dc.identifier.doi | https://doi.org/10.1136/heartjnl-2022-321608 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 1355-6037 | |
dc.type.version | AcceptedVersion | |