Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles
dc.date.accessioned | 2023-01-13T17:30:32Z | |
dc.date.available | 2023-01-13T17:30:32Z | |
dc.date.created | 2023-01-04T14:28:01Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Hautakangas, Heidi Winsvold, Bendik K S Ruotsalainen, Sanni Bjornsdottir, Gyda Harder, Aster V. E. Kogelman, Lisette J. A. Thomas, Laurent Noordam, Raymond Benner, Christian Gormley, Padhraig Artto, Ville Banasik, Karina Bjornsdottir, Anna Boomsma, Dorret I. Brumpton, Ben Michael Burgdorf, Kristoffer Sølvsten Buring, Julie E. Chalmer, Mona Ameri de Boer, Irene Dichgans, Martin Erikstrup, Christian Färkkilä, Markus Gabrielsen, Maiken Elvestad Ghanbari, Mohsen Hagen, Knut Häppölä, Paavo Hottenga, Jouke-Jan Hrafnsdottir, Maria G. Hveem, Kristian Johnsen, Marianne Bakke Kähönen, Mika Kristoffersen, Espen Saxhaug Kurth, Tobias Lehtimäki, Terho Lighart, Lannie Magnusson, Sigurdur H. Malik, Rainer Pedersen, Ole Birger Pelzer, Nadine Penninx, Brenda W. J. H. Ran, Caroline Ridker, Paul M. Rosendaal, Frits Richard Sigurdardottir, Gudrun R. Skogholt, Anne Heidi Sveinsson, Olafur A. Thorgeirsson, Thorgeir E. Ullum, Henrik Zwart, John Anker Henrik . Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles. Nature Genetics. 2022, 54, 152-160 | |
dc.identifier.uri | http://hdl.handle.net/10852/98721 | |
dc.description.abstract | Abstract Migraine affects over a billion individuals worldwide but its genetic underpinning remains largely unknown. Here, we performed a genome-wide association study of 102,084 migraine cases and 771,257 controls and identified 123 loci, of which 86 are previously unknown. These loci provide an opportunity to evaluate shared and distinct genetic components in the two main migraine subtypes: migraine with aura and migraine without aura. Stratification of the risk loci using 29,679 cases with subtype information indicated three risk variants that seem specific for migraine with aura (in HMOX2 , CACNA1A and MPPED2 ), two that seem specific for migraine without aura (near SPINK2 and near FECH ) and nine that increase susceptibility for migraine regardless of subtype. The new risk loci include genes encoding recent migraine-specific drug targets, namely calcitonin gene-related peptide ( CALCA/CALCB ) and serotonin 1F receptor ( HTR1F ). Overall, genomic annotations among migraine-associated variants were enriched in both vascular and central nervous system tissue/cell types, supporting unequivocally that neurovascular mechanisms underlie migraine pathophysiology. | |
dc.language | EN | |
dc.publisher | Nature Portfolio | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles | |
dc.title.alternative | ENEngelskEnglishGenome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles | |
dc.type | Journal article | |
dc.creator.author | Hautakangas, Heidi | |
dc.creator.author | Winsvold, Bendik K S | |
dc.creator.author | Ruotsalainen, Sanni | |
dc.creator.author | Bjornsdottir, Gyda | |
dc.creator.author | Harder, Aster V. E. | |
dc.creator.author | Kogelman, Lisette J. A. | |
dc.creator.author | Thomas, Laurent | |
dc.creator.author | Noordam, Raymond | |
dc.creator.author | Benner, Christian | |
dc.creator.author | Gormley, Padhraig | |
dc.creator.author | Artto, Ville | |
dc.creator.author | Banasik, Karina | |
dc.creator.author | Bjornsdottir, Anna | |
dc.creator.author | Boomsma, Dorret I. | |
dc.creator.author | Brumpton, Ben Michael | |
dc.creator.author | Burgdorf, Kristoffer Sølvsten | |
dc.creator.author | Buring, Julie E. | |
dc.creator.author | Chalmer, Mona Ameri | |
dc.creator.author | de Boer, Irene | |
dc.creator.author | Dichgans, Martin | |
dc.creator.author | Erikstrup, Christian | |
dc.creator.author | Färkkilä, Markus | |
dc.creator.author | Gabrielsen, Maiken Elvestad | |
dc.creator.author | Ghanbari, Mohsen | |
dc.creator.author | Hagen, Knut | |
dc.creator.author | Häppölä, Paavo | |
dc.creator.author | Hottenga, Jouke-Jan | |
dc.creator.author | Hrafnsdottir, Maria G. | |
dc.creator.author | Hveem, Kristian | |
dc.creator.author | Johnsen, Marianne Bakke | |
dc.creator.author | Kähönen, Mika | |
dc.creator.author | Kristoffersen, Espen Saxhaug | |
dc.creator.author | Kurth, Tobias | |
dc.creator.author | Lehtimäki, Terho | |
dc.creator.author | Lighart, Lannie | |
dc.creator.author | Magnusson, Sigurdur H. | |
dc.creator.author | Malik, Rainer | |
dc.creator.author | Pedersen, Ole Birger | |
dc.creator.author | Pelzer, Nadine | |
dc.creator.author | Penninx, Brenda W. J. H. | |
dc.creator.author | Ran, Caroline | |
dc.creator.author | Ridker, Paul M. | |
dc.creator.author | Rosendaal, Frits Richard | |
dc.creator.author | Sigurdardottir, Gudrun R. | |
dc.creator.author | Skogholt, Anne Heidi | |
dc.creator.author | Sveinsson, Olafur A. | |
dc.creator.author | Thorgeirsson, Thorgeir E. | |
dc.creator.author | Ullum, Henrik | |
dc.creator.author | Zwart, John Anker Henrik | |
cristin.unitcode | 185,53,42,0 | |
cristin.unitname | Nevroklinikken | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |
dc.identifier.cristin | 2100637 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nature Genetics&rft.volume=54&rft.spage=152&rft.date=2022 | |
dc.identifier.jtitle | Nature Genetics | |
dc.identifier.volume | 54 | |
dc.identifier.issue | 2 | |
dc.identifier.startpage | 152 | |
dc.identifier.endpage | 160 | |
dc.identifier.doi | https://doi.org/10.1038/s41588-021-00990-0 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 1061-4036 | |
dc.type.version | PublishedVersion |
Files in this item
Appears in the following Collection
-
Institutt for helse og samfunn [2976]
-
Institutt for klinisk medisin [10814]
-
CRIStin høstingsarkiv [31446]