dc.date.accessioned | 2023-01-06T17:58:31Z | |
dc.date.available | 2023-01-06T17:58:31Z | |
dc.date.created | 2022-11-17T14:21:00Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Sengupta, Tanima Lefol, Yohan Pierre Lirussi, Lisa Suaste Morales, Veronica Lüders, Torben Gupta, Swapnil Aman, Yahyah Sharma, Kulbhushan Fang, Evandro Fei Nilsen, Hilde Loge . Krill oil protects dopaminergic neurons from age-related degeneration through temporal transcriptome rewiring and suppression of several hallmarks of aging. Aging. 2022, 14(21), 8661-8687 | |
dc.identifier.uri | http://hdl.handle.net/10852/98533 | |
dc.description.abstract | There is accumulating evidence that interfering with the basic aging mechanisms can enhance healthy longevity. The interventional/therapeutic strategies targeting multiple aging hallmarks could be more effective than targeting one hallmark. While health-promoting qualities of marine oils have been extensively studied, the underlying molecular mechanisms are not fully understood. Lipid extracts from Antarctic krill are rich in long-chain omega-3 fatty acids choline, and astaxanthin. Here, we used C. elegans and human cells to investigate whether krill oil promotes healthy aging. In a C. elegans model of Parkinson´s disease, we show that krill oil protects dopaminergic neurons from aging-related degeneration, decreases alpha-synuclein aggregation, and improves dopamine-dependent behavior and cognition. Krill oil rewires distinct gene expression programs that contribute to attenuating several aging hallmarks, including oxidative stress, proteotoxic stress, senescence, genomic instability, and mitochondrial dysfunction. Mechanistically, krill oil increases neuronal resilience through temporal transcriptome rewiring to promote anti-oxidative stress and anti-inflammation via healthspan regulating transcription factors such as SNK-1. Moreover, krill oil promotes dopaminergic neuron survival through regulation of synaptic transmission and neuronal functions via PBO-2 and RIM-1. Collectively, krill oil rewires global gene expression programs and promotes healthy aging via abrogating multiple aging hallmarks, suggesting directions for further pre-clinical and clinical explorations. | |
dc.language | EN | |
dc.publisher | Impact Journals LLC | |
dc.rights | Attribution 3.0 Unported | |
dc.rights.uri | https://creativecommons.org/licenses/by/3.0/ | |
dc.title | Krill oil protects dopaminergic neurons from age-related degeneration through temporal transcriptome rewiring and suppression of several hallmarks of aging | |
dc.title.alternative | ENEngelskEnglishKrill oil protects dopaminergic neurons from age-related degeneration through temporal transcriptome rewiring and suppression of several hallmarks of aging | |
dc.type | Journal article | |
dc.creator.author | Sengupta, Tanima | |
dc.creator.author | Lefol, Yohan Pierre | |
dc.creator.author | Lirussi, Lisa | |
dc.creator.author | Suaste Morales, Veronica | |
dc.creator.author | Lüders, Torben | |
dc.creator.author | Gupta, Swapnil | |
dc.creator.author | Aman, Yahyah | |
dc.creator.author | Sharma, Kulbhushan | |
dc.creator.author | Fang, Evandro Fei | |
dc.creator.author | Nilsen, Hilde Loge | |
cristin.unitcode | 185,53,82,10 | |
cristin.unitname | Avdeling for klinisk molekylærbiologi | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 2075686 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Aging&rft.volume=14&rft.spage=8661&rft.date=2022 | |
dc.identifier.jtitle | Aging | |
dc.identifier.volume | 14 | |
dc.identifier.issue | 21 | |
dc.identifier.startpage | 8661 | |
dc.identifier.endpage | 8687 | |
dc.identifier.doi | https://doi.org/10.18632/aging.204375 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 1945-4589 | |
dc.type.version | PublishedVersion | |
dc.relation.project | NFR/302483 | |
dc.relation.project | EC/H2020/945371 | |