dc.date.accessioned | 2023-01-03T17:39:25Z | |
dc.date.available | 2023-01-03T17:39:25Z | |
dc.date.created | 2022-12-20T14:01:19Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Åbjørsbråten, Knut Sindre Skaaraas, Gry HE Syverstad Cunen, Celine Marie Løken Bjørnstad, Daniel Marelius Binder, Kristin M Gullestad Bojarskaite, Laura Jensen, Vidar Nilsson, Lars Rao, Shreyas B. Tang, Wannan Hermansen, Gudmund Horn Nagelhus, Erlend Arnulf Ottersen, Ole Petter Torp, Reidun Enger, Rune . Impaired astrocytic Ca2+ signaling in awake-behaving Alzheimer’s disease transgenic mice. eLIFE. 2022 | |
dc.identifier.uri | http://hdl.handle.net/10852/98461 | |
dc.description.abstract | Increased astrocytic Ca 2+ signaling has been shown in Alzheimer’s disease mouse models, but to date no reports have characterized behaviorally induced astrocytic Ca 2+ signaling in such mice. Here, we employ an event-based algorithm to assess astrocytic Ca 2+ signals in the neocortex of awake-behaving tg-ArcSwe mice and non-transgenic wildtype littermates while monitoring pupil responses and behavior. We demonstrate an attenuated astrocytic Ca 2+ response to locomotion and an uncoupling of pupil responses and astrocytic Ca 2+ signaling in 15-month-old plaque-bearing mice. Using the genetically encoded fluorescent norepinephrine sensor GRAB NE , we demonstrate a reduced norepinephrine signaling during spontaneous running and startle responses in the transgenic mice, providing a possible mechanistic underpinning of the observed reduced astrocytic Ca 2+ responses. Our data points to a dysfunction in the norepinephrine–astrocyte Ca 2+ activity axis, which may account for some of the cognitive deficits observed in Alzheimer’s disease. | |
dc.language | EN | |
dc.publisher | eLife Sciences Publications Ltd | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | Impaired astrocytic Ca2+ signaling in awake-behaving Alzheimer’s disease transgenic mice | |
dc.title.alternative | ENEngelskEnglishImpaired astrocytic Ca2+ signaling in awake-behaving Alzheimer’s disease transgenic mice | |
dc.type | Journal article | |
dc.creator.author | Åbjørsbråten, Knut Sindre | |
dc.creator.author | Skaaraas, Gry HE Syverstad | |
dc.creator.author | Cunen, Celine Marie Løken | |
dc.creator.author | Bjørnstad, Daniel Marelius | |
dc.creator.author | Binder, Kristin M Gullestad | |
dc.creator.author | Bojarskaite, Laura | |
dc.creator.author | Jensen, Vidar | |
dc.creator.author | Nilsson, Lars | |
dc.creator.author | Rao, Shreyas B. | |
dc.creator.author | Tang, Wannan | |
dc.creator.author | Hermansen, Gudmund Horn | |
dc.creator.author | Nagelhus, Erlend Arnulf | |
dc.creator.author | Ottersen, Ole Petter | |
dc.creator.author | Torp, Reidun | |
dc.creator.author | Enger, Rune | |
cristin.unitcode | 185,51,12,30 | |
cristin.unitname | Seksjon for anatomi | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |
dc.identifier.cristin | 2095785 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=eLIFE&rft.volume=&rft.spage=&rft.date=2022 | |
dc.identifier.jtitle | eLIFE | |
dc.identifier.volume | 11 | |
dc.identifier.doi | https://doi.org/10.7554/eLife.75055 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 2050-084X | |
dc.type.version | PublishedVersion | |