Functional precision cancer medicine: drug sensitivity screening enabled by cell culture models

dc.date.accessioned	2022-12-12T17:27:36Z
dc.date.available	2023-09-23T22:45:49Z
dc.date.created	2022-11-10T10:20:33Z
dc.date.issued	2022
dc.identifier.citation	Flobak, Åsmund Skånland, Sigrid S Hovig, Eivind Tasken, Kjetil Russnes, Hege Elisabeth Giercksky . Functional precision cancer medicine: drug sensitivity screening enabled by cell culture models. TIPS - Trends in Pharmacological Sciences. 2022, 43(11), 973-985
dc.identifier.uri	http://hdl.handle.net/10852/98114
dc.description.abstract	Functional precision medicine is a new, emerging area that can guide cancer treatment by capturing information from direct perturbations of tumor-derived, living cells, such as by drug sensitivity screening. Precision cancer medicine as currently implemented in clinical practice has been driven by genomics, and current molecular tumor boards rely extensively on genomic characterization to advise on therapeutic interventions. However, genomic biomarkers can only guide treatment decisions for a fraction of the patients. In this review we provide an overview of the current state of functional precision medicine, highlight advances for drug-sensitivity screening enabled by cell culture models, and discuss how artificial intelligence (AI) can be coupled to functional precision medicine to guide patient stratification.
dc.language	EN
dc.rights	Attribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.uri	https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.title	Functional precision cancer medicine: drug sensitivity screening enabled by cell culture models
dc.title.alternative	ENEngelskEnglishFunctional precision cancer medicine: drug sensitivity screening enabled by cell culture models
dc.type	Journal article
dc.creator.author	Flobak, Åsmund
dc.creator.author	Skånland, Sigrid S
dc.creator.author	Hovig, Eivind
dc.creator.author	Tasken, Kjetil
dc.creator.author	Russnes, Hege Elisabeth Giercksky
cristin.unitcode	185,53,18,75
cristin.unitname	K.G. Jebsen senter for B-cellekreft
cristin.ispublished	true
cristin.fulltext	postprint
cristin.qualitycode	1
dc.identifier.cristin	2071602
dc.identifier.bibliographiccitation	info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=TIPS - Trends in Pharmacological Sciences&rft.volume=43&rft.spage=973&rft.date=2022
dc.identifier.jtitle	TIPS - Trends in Pharmacological Sciences
dc.identifier.volume	43
dc.identifier.issue	11
dc.identifier.startpage	973
dc.identifier.endpage	985
dc.identifier.doi	https://doi.org/10.1016/j.tips.2022.08.009
dc.type.document	Tidsskriftartikkel
dc.type.peerreviewed	Peer reviewed
dc.source.issn	0165-6147
dc.type.version	AcceptedVersion
dc.relation.project	NFR/310160
dc.relation.project	NFR/294916
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dc.relation.project	KF/215850
dc.relation.project	HSØ/2019057
dc.relation.project	HSØ/2021082
dc.relation.project	NFR/315538
dc.relation.project	NFR/329059