dc.date.accessioned | 2022-12-09T18:01:24Z | |
dc.date.available | 2022-12-09T18:01:24Z | |
dc.date.created | 2022-11-30T15:30:09Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Sahakyan, Mushegh Aghayan, Davit Edwin, Bjørn von Gohren Alikhanov, Ruslan Britskaia, Natalia Brudvik, Kristoffer Watten D’Hondt, Mathieu De Meyere, Celine Efanov, Mikhail Fretland, Åsmund Avdem Hoff, Rune Ismail, Warsan Ivanecz, Arpad Kazaryan, Airazat Lassen, Kristoffer Magdalenić, Tomislav Parmentier, Isabelle Røsok, Bård Ingvald Villanger, Olaug Yaqub, Sheraz . Laparoscopic versus open liver resection for intrahepatic cholangiocarcinoma: a multicenter propensity score-matched study. Scandinavian Journal of Gastroenterology. 2022 | |
dc.identifier.uri | http://hdl.handle.net/10852/98054 | |
dc.description.abstract | Background
The role of laparoscopy in the treatment of intrahepatic cholangiocarcinoma (ICC) remains unclear. This multicenter study examined the outcomes of laparoscopic liver resection for ICC.
Methods
Patients with ICC who had undergone laparoscopic or open liver resection between 2012 and 2019 at four European expert centers were included in the study. Laparoscopic and open approaches were compared in terms of surgical and oncological outcomes. Propensity score matching was used for minimizing treatment selection bias and adjusting for confounders (age, ASA grade, tumor size, location, number of tumors and underlying liver disease).
Results
Of 136 patients, 50 (36.7%) underwent laparoscopic resection, whereas 86 (63.3%) had open surgery. Median tumor size was larger (73.6 vs 55.1 mm, p = 0.01) and the incidence of bi-lobar tumors was higher (36.6 vs 6%, p < 0.01) in patients undergoing open surgery. After propensity score matching baseline characteristics were comparable although open surgery was associated with a larger fraction of major liver resections (74 vs 38%, p < 0.01), lymphadenectomy (60 vs 20%, p < 0.01) and longer operative time (294 vs 209 min, p < 0.01). Tumor characteristics were similar. Laparoscopic resection resulted in less complications (30 vs 52%, p = 0.025), fewer reoperations (4 vs 16%, p = 0.046) and shorter hospital stay (5 vs 8 days, p < 0.01). No differences were found in terms of recurrence, recurrence-free and overall survival.
Conclusion
Laparoscopic resection seems to be associated with improved short-term and with similar long-term outcomes compared with open surgery in patients with ICC. However, possible selection criteria for laparoscopic surgery are yet to be defined. | |
dc.language | EN | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.title | Laparoscopic versus open liver resection for intrahepatic cholangiocarcinoma: a multicenter propensity score-matched study | |
dc.title.alternative | ENEngelskEnglishLaparoscopic versus open liver resection for intrahepatic cholangiocarcinoma: a multicenter propensity score-matched study | |
dc.type | Journal article | |
dc.creator.author | Sahakyan, Mushegh | |
dc.creator.author | Aghayan, Davit | |
dc.creator.author | Edwin, Bjørn von Gohren | |
dc.creator.author | Alikhanov, Ruslan | |
dc.creator.author | Britskaia, Natalia | |
dc.creator.author | Brudvik, Kristoffer Watten | |
dc.creator.author | D’Hondt, Mathieu | |
dc.creator.author | De Meyere, Celine | |
dc.creator.author | Efanov, Mikhail | |
dc.creator.author | Fretland, Åsmund Avdem | |
dc.creator.author | Hoff, Rune | |
dc.creator.author | Ismail, Warsan | |
dc.creator.author | Ivanecz, Arpad | |
dc.creator.author | Kazaryan, Airazat | |
dc.creator.author | Lassen, Kristoffer | |
dc.creator.author | Magdalenić, Tomislav | |
dc.creator.author | Parmentier, Isabelle | |
dc.creator.author | Røsok, Bård Ingvald | |
dc.creator.author | Villanger, Olaug | |
dc.creator.author | Yaqub, Sheraz | |
cristin.unitcode | 185,53,2,17 | |
cristin.unitname | Intervensjonssenteret | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 2086081 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Scandinavian Journal of Gastroenterology&rft.volume=&rft.spage=&rft.date=2022 | |
dc.identifier.jtitle | Scandinavian Journal of Gastroenterology | |
dc.identifier.startpage | 1 | |
dc.identifier.endpage | 8 | |
dc.identifier.doi | https://doi.org/10.1080/00365521.2022.2143724 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 0036-5521 | |
dc.type.version | PublishedVersion | |
dc.relation.project | NFR/311393 | |