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Serum metabolome associated with severity of acute traumatic brain injury

dc.date.accessioned2022-12-08T17:47:21Z
dc.date.available2022-12-08T17:47:21Z
dc.date.created2022-10-12T11:54:08Z
dc.date.issued2022
dc.identifier.citationThomas, Ilias Dickens, Alex M. Posti, Jussi P. Czeiter, Endre Duberg, Daniel Sinioja, Tim Kråkström, Matilda Retel Helmrich, Isabel R. A. Wang, Kevin K. W. Maas, Andrew I. R. Steyerberg, Ewout W. Menon, David K. Tenovuo, Olli Hyötyläinen, Tuulia Büki, András Orešič, Matej Åkerlund, Cecilia Amrein, Krisztina Andelic, Nada Andreassen, Lasse Anke, Audny Gabriele Wagner Antoni, Anna Audibert, Gérard Azouvi, Philippe Azzolini, Maria Luisa Bartels, Ronald Barzó, Pál Beauvais, Romuald Beer, Ronny Bellander, Bo-Michael Belli, Antonio Benali, Habib Berardino, Maurizio Beretta, Luigi Blaabjerg, Morten Bragge, Peter Brazinova, Alexandra Brinck, Vibeke Brooker, Joanne Brorsson, Camilla Bullinger, Monika Cabeleira, Manuel Caccioppola, Alessio Calappi, Emiliana Calvi, Maria Rosa Cameron, Peter Lozano, Guillermo Carbayo Carbonara, Marco Cavallo, Simona Chevallard, Giorgio Chieregato, Arturo Citerio, Giuseppe Clusmann, Hans Coburn, Mark Coles, Jonathan Cooper, Jamie D. Correia, Marta Čović, Amra Curry, Nicola Czeiter, Endre Czosnyka, Marek Dahyot-Fizelier, Claire Dark, Paul Dawes, Helen De Keyser, Véronique Degos, Vincent Corte, Francesco Della den Boogert, Hugo Depreitere, Bart Đilvesi, Đula Dixit, Abhishek Donoghue, Emma Dreier, Jens Dulière, Guy-Loup Ercole, Ari Esser, Patrick Ezer, Erzsébet Fabricius, Martin Feigin, Valery L. Foks, Kelly Frisvold, Shirin Furmanov, Alex Gagliardo, Pablo Galanaud, Damien Gantner, Dashiell Gao, Guoyi George, Pradeep Ghuysen, Alexandre Giga, Lelde Glocker, Ben Golubovic, Jagoš Gomez, Pedro A. Gratz, Johannes Gravesteijn, Benjamin Grossi, Francesca Gruen, Russell L. Gupta, Deepak Haagsma, Juanita A. Haitsma, Iain Helbok, Raimund Helseth, Eirik Horton, Lindsay Huijben, Jilske Hutchinson, Peter J. Jacobs, Bram Jankowski, Stefan Jarrett, Mike Jiang, Ji-yao Johnson, Faye Jones, Kelly Karan, Mladen Kolias, Angelos G. Kompanje, Erwin Kondziella, Daniel Kornaropoulos, Evgenios Koskinen, Lars-Owe Kovács, Noémi Kowark, Ana Lagares, Alfonso Lanyon, Linda Laureys, Steven Lecky, Fiona Ledoux, Didier Lefering, Rolf Legrand, Valerie Lejeune, Aurelie Levi, Leon Lightfoot, Roger Lingsma, Hester Maas, Andrew I. R. Castaño-León, Ana M. Maegele, Marc Majdan, Marek Manara, Alex Manley, Geoffrey Martino, Costanza Maréchal, Hugues Mattern, Julia McMahon, Catherine Melegh, Béla Menovsky, Tomas Mikolic, Ana Misset, Benoit Muraleedharan, Visakh Murray, Lynnette Negru, Ancuta Nelson, David Newcombe, Virginia Nieboer, Daan Nyirádi, József Olubukola, Otesile Ortolano, Fabrizio Palotie, Aarno Parizel, Paul M. Payen, Jean-François Perera, Natascha Perlbarg, Vincent Persona, Paolo Peul, Wilco Piippo-Karjalainen, Anna Pirinen, Matti Ples, Horia Polinder, Suzanne Pomposo, Inigo Posti, Jussi P. Puybasset, Louis Radoi, Andreea Ragauskas, Arminas Raj, Rahul Rambadagalla, Malinka Rhodes, Jonathan Richardson, Sylvia Richter, Sophie Ripatti, Samuli Rocka, Saulius Røe, Cecilie Røise, Olav Rosand, Jonathan Rosenfeld, Jeffrey V. Rosenlund, Christina Rosenthal, Guy Rossaint, Rolf Rossi, Sandra Rueckert, Daniel Rusnák, Martin Sahuquillo, Juan Sakowitz, Oliver Sanchez-Porras, Renan Sandor, Janos Schäfer, Nadine Schmidt, Silke Schoechl, Herbert Schoonman, Guus Schou, Rico Frederik Schwendenwein, Elisabeth Sewalt, Charlie Skandsen, Toril Smielewski, Peter Sorinola, Abayomi Stamatakis, Emmanuel Stanworth, Simon Stevens, Robert Stewart, William Stocchetti, Nino Sundström, Nina Takala, Riikka Tamás, Viktória Tamosuitis, Tomas Taylor, Mark Steven Te Ao, Braden Theadom, Alice Thomas, Matt Tibboel, Dick Timmers, Marjolein Tolias, Christos Trapani, Tony Tudora, Cristina Maria Unterberg, Andreas Vajkoczy, Peter Vallance, Shirley Valeinis, Egils Vámos, Zoltán van der Jagt, Mathieu Van der Steen, Gregory van der Naalt, Joukje van Dijck, Jeroen T. J. M. van Essen, Thomas A. Van Hecke, Wim van Heugten, Caroline Van Praag, Dominique Vyvere, Thijs Vande van Wijk, Roel P. J. Vargiolu, Alessia Vega, Emmanuel Velt, Kimberley Verheyden, Jan Vespa, Paul M. Vik, Anne Vilcinis, Rimantas Volovici, Victor von Steinbüchel, Nicole Voormolen, Daphne Vulekovic, Petar Wiegers, Eveline Williams, Guy Wilson, Lindsay Winzeck, Stefan Wolf, Stefan Yang, Zhihui Ylén, Peter Younsi, Alexander Zeiler, Frederick A. Zelinkova, Veronika Ziverte, Agate Zoerle, Tommaso . Serum metabolome associated with severity of acute traumatic brain injury. Nature Communications. 2022, 13(1), 1-15
dc.identifier.urihttp://hdl.handle.net/10852/98001
dc.description.abstractAbstract Complex metabolic disruption is a crucial aspect of the pathophysiology of traumatic brain injury (TBI). Associations between this and systemic metabolism and their potential prognostic value are poorly understood. Here, we aimed to describe the serum metabolome (including lipidome) associated with acute TBI within 24 h post-injury, and its relationship to severity of injury and patient outcome. We performed a comprehensive metabolomics study in a cohort of 716 patients with TBI and non-TBI reference patients (orthopedic, internal medicine, and other neurological patients) from the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) cohort. We identified panels of metabolites specifically associated with TBI severity and patient outcomes. Choline phospholipids (lysophosphatidylcholines, ether phosphatidylcholines and sphingomyelins) were inversely associated with TBI severity and were among the strongest predictors of TBI patient outcomes, which was further confirmed in a separate validation dataset of 558 patients. The observed metabolic patterns may reflect different pathophysiological mechanisms, including protective changes of systemic lipid metabolism aiming to maintain lipid homeostasis in the brain.
dc.languageEN
dc.publisherNature Portfolio
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleSerum metabolome associated with severity of acute traumatic brain injury
dc.title.alternativeENEngelskEnglishSerum metabolome associated with severity of acute traumatic brain injury
dc.typeJournal article
dc.creator.authorThomas, Ilias
dc.creator.authorDickens, Alex M.
dc.creator.authorPosti, Jussi P.
dc.creator.authorCzeiter, Endre
dc.creator.authorDuberg, Daniel
dc.creator.authorSinioja, Tim
dc.creator.authorKråkström, Matilda
dc.creator.authorRetel Helmrich, Isabel R. A.
dc.creator.authorWang, Kevin K. W.
dc.creator.authorMaas, Andrew I. R.
dc.creator.authorSteyerberg, Ewout W.
dc.creator.authorMenon, David K.
dc.creator.authorTenovuo, Olli
dc.creator.authorHyötyläinen, Tuulia
dc.creator.authorBüki, András
dc.creator.authorOrešič, Matej
dc.creator.authorÅkerlund, Cecilia
dc.creator.authorAmrein, Krisztina
dc.creator.authorAndelic, Nada
dc.creator.authorAndreassen, Lasse
dc.creator.authorAnke, Audny Gabriele Wagner
dc.creator.authorAntoni, Anna
dc.creator.authorAudibert, Gérard
dc.creator.authorAzouvi, Philippe
dc.creator.authorAzzolini, Maria Luisa
dc.creator.authorBartels, Ronald
dc.creator.authorBarzó, Pál
dc.creator.authorBeauvais, Romuald
dc.creator.authorBeer, Ronny
dc.creator.authorBellander, Bo-Michael
dc.creator.authorBelli, Antonio
dc.creator.authorBenali, Habib
dc.creator.authorBerardino, Maurizio
dc.creator.authorBeretta, Luigi
dc.creator.authorBlaabjerg, Morten
dc.creator.authorBragge, Peter
dc.creator.authorBrazinova, Alexandra
dc.creator.authorBrinck, Vibeke
dc.creator.authorBrooker, Joanne
dc.creator.authorBrorsson, Camilla
dc.creator.authorBullinger, Monika
dc.creator.authorCabeleira, Manuel
dc.creator.authorCaccioppola, Alessio
dc.creator.authorCalappi, Emiliana
dc.creator.authorCalvi, Maria Rosa
dc.creator.authorCameron, Peter
dc.creator.authorLozano, Guillermo Carbayo
dc.creator.authorCarbonara, Marco
dc.creator.authorCavallo, Simona
dc.creator.authorChevallard, Giorgio
dc.creator.authorChieregato, Arturo
dc.creator.authorCiterio, Giuseppe
dc.creator.authorClusmann, Hans
dc.creator.authorCoburn, Mark
dc.creator.authorColes, Jonathan
dc.creator.authorCooper, Jamie D.
dc.creator.authorCorreia, Marta
dc.creator.authorČović, Amra
dc.creator.authorCurry, Nicola
dc.creator.authorCzeiter, Endre
dc.creator.authorCzosnyka, Marek
dc.creator.authorDahyot-Fizelier, Claire
dc.creator.authorDark, Paul
dc.creator.authorDawes, Helen
dc.creator.authorDe Keyser, Véronique
dc.creator.authorDegos, Vincent
dc.creator.authorCorte, Francesco Della
dc.creator.authorden Boogert, Hugo
dc.creator.authorDepreitere, Bart
dc.creator.authorĐilvesi, Đula
dc.creator.authorDixit, Abhishek
dc.creator.authorDonoghue, Emma
dc.creator.authorDreier, Jens
dc.creator.authorDulière, Guy-Loup
dc.creator.authorErcole, Ari
dc.creator.authorEsser, Patrick
dc.creator.authorEzer, Erzsébet
dc.creator.authorFabricius, Martin
dc.creator.authorFeigin, Valery L.
dc.creator.authorFoks, Kelly
dc.creator.authorFrisvold, Shirin
dc.creator.authorFurmanov, Alex
dc.creator.authorGagliardo, Pablo
dc.creator.authorGalanaud, Damien
dc.creator.authorGantner, Dashiell
dc.creator.authorGao, Guoyi
dc.creator.authorGeorge, Pradeep
dc.creator.authorGhuysen, Alexandre
dc.creator.authorGiga, Lelde
dc.creator.authorGlocker, Ben
dc.creator.authorGolubovic, Jagoš
dc.creator.authorGomez, Pedro A.
dc.creator.authorGratz, Johannes
dc.creator.authorGravesteijn, Benjamin
dc.creator.authorGrossi, Francesca
dc.creator.authorGruen, Russell L.
dc.creator.authorGupta, Deepak
dc.creator.authorHaagsma, Juanita A.
dc.creator.authorHaitsma, Iain
dc.creator.authorHelbok, Raimund
dc.creator.authorHelseth, Eirik
dc.creator.authorHorton, Lindsay
dc.creator.authorHuijben, Jilske
dc.creator.authorHutchinson, Peter J.
dc.creator.authorJacobs, Bram
dc.creator.authorJankowski, Stefan
dc.creator.authorJarrett, Mike
dc.creator.authorJiang, Ji-yao
dc.creator.authorJohnson, Faye
dc.creator.authorJones, Kelly
dc.creator.authorKaran, Mladen
dc.creator.authorKolias, Angelos G.
dc.creator.authorKompanje, Erwin
dc.creator.authorKondziella, Daniel
dc.creator.authorKornaropoulos, Evgenios
dc.creator.authorKoskinen, Lars-Owe
dc.creator.authorKovács, Noémi
dc.creator.authorKowark, Ana
dc.creator.authorLagares, Alfonso
dc.creator.authorLanyon, Linda
dc.creator.authorLaureys, Steven
dc.creator.authorLecky, Fiona
dc.creator.authorLedoux, Didier
dc.creator.authorLefering, Rolf
dc.creator.authorLegrand, Valerie
dc.creator.authorLejeune, Aurelie
dc.creator.authorLevi, Leon
dc.creator.authorLightfoot, Roger
dc.creator.authorLingsma, Hester
dc.creator.authorMaas, Andrew I. R.
dc.creator.authorCastaño-León, Ana M.
dc.creator.authorMaegele, Marc
dc.creator.authorMajdan, Marek
dc.creator.authorManara, Alex
dc.creator.authorManley, Geoffrey
dc.creator.authorMartino, Costanza
dc.creator.authorMaréchal, Hugues
dc.creator.authorMattern, Julia
dc.creator.authorMcMahon, Catherine
dc.creator.authorMelegh, Béla
dc.creator.authorMenovsky, Tomas
dc.creator.authorMikolic, Ana
dc.creator.authorMisset, Benoit
dc.creator.authorMuraleedharan, Visakh
dc.creator.authorMurray, Lynnette
dc.creator.authorNegru, Ancuta
dc.creator.authorNelson, David
dc.creator.authorNewcombe, Virginia
dc.creator.authorNieboer, Daan
dc.creator.authorNyirádi, József
dc.creator.authorOlubukola, Otesile
dc.creator.authorOrtolano, Fabrizio
dc.creator.authorPalotie, Aarno
dc.creator.authorParizel, Paul M.
dc.creator.authorPayen, Jean-François
dc.creator.authorPerera, Natascha
dc.creator.authorPerlbarg, Vincent
dc.creator.authorPersona, Paolo
dc.creator.authorPeul, Wilco
dc.creator.authorPiippo-Karjalainen, Anna
dc.creator.authorPirinen, Matti
dc.creator.authorPles, Horia
dc.creator.authorPolinder, Suzanne
dc.creator.authorPomposo, Inigo
dc.creator.authorPosti, Jussi P.
dc.creator.authorPuybasset, Louis
dc.creator.authorRadoi, Andreea
dc.creator.authorRagauskas, Arminas
dc.creator.authorRaj, Rahul
dc.creator.authorRambadagalla, Malinka
dc.creator.authorRhodes, Jonathan
dc.creator.authorRichardson, Sylvia
dc.creator.authorRichter, Sophie
dc.creator.authorRipatti, Samuli
dc.creator.authorRocka, Saulius
dc.creator.authorRøe, Cecilie
dc.creator.authorRøise, Olav
dc.creator.authorRosand, Jonathan
dc.creator.authorRosenfeld, Jeffrey V.
dc.creator.authorRosenlund, Christina
dc.creator.authorRosenthal, Guy
dc.creator.authorRossaint, Rolf
dc.creator.authorRossi, Sandra
dc.creator.authorRueckert, Daniel
dc.creator.authorRusnák, Martin
dc.creator.authorSahuquillo, Juan
dc.creator.authorSakowitz, Oliver
dc.creator.authorSanchez-Porras, Renan
dc.creator.authorSandor, Janos
dc.creator.authorSchäfer, Nadine
dc.creator.authorSchmidt, Silke
dc.creator.authorSchoechl, Herbert
dc.creator.authorSchoonman, Guus
dc.creator.authorSchou, Rico Frederik
dc.creator.authorSchwendenwein, Elisabeth
dc.creator.authorSewalt, Charlie
dc.creator.authorSkandsen, Toril
dc.creator.authorSmielewski, Peter
dc.creator.authorSorinola, Abayomi
dc.creator.authorStamatakis, Emmanuel
dc.creator.authorStanworth, Simon
dc.creator.authorStevens, Robert
dc.creator.authorStewart, William
dc.creator.authorStocchetti, Nino
dc.creator.authorSundström, Nina
dc.creator.authorTakala, Riikka
dc.creator.authorTamás, Viktória
dc.creator.authorTamosuitis, Tomas
dc.creator.authorTaylor, Mark Steven
dc.creator.authorTe Ao, Braden
dc.creator.authorTheadom, Alice
dc.creator.authorThomas, Matt
dc.creator.authorTibboel, Dick
dc.creator.authorTimmers, Marjolein
dc.creator.authorTolias, Christos
dc.creator.authorTrapani, Tony
dc.creator.authorTudora, Cristina Maria
dc.creator.authorUnterberg, Andreas
dc.creator.authorVajkoczy, Peter
dc.creator.authorVallance, Shirley
dc.creator.authorValeinis, Egils
dc.creator.authorVámos, Zoltán
dc.creator.authorvan der Jagt, Mathieu
dc.creator.authorVan der Steen, Gregory
dc.creator.authorvan der Naalt, Joukje
dc.creator.authorvan Dijck, Jeroen T. J. M.
dc.creator.authorvan Essen, Thomas A.
dc.creator.authorVan Hecke, Wim
dc.creator.authorvan Heugten, Caroline
dc.creator.authorVan Praag, Dominique
dc.creator.authorVyvere, Thijs Vande
dc.creator.authorvan Wijk, Roel P. J.
dc.creator.authorVargiolu, Alessia
dc.creator.authorVega, Emmanuel
dc.creator.authorVelt, Kimberley
dc.creator.authorVerheyden, Jan
dc.creator.authorVespa, Paul M.
dc.creator.authorVik, Anne
dc.creator.authorVilcinis, Rimantas
dc.creator.authorVolovici, Victor
dc.creator.authorvon Steinbüchel, Nicole
dc.creator.authorVoormolen, Daphne
dc.creator.authorVulekovic, Petar
dc.creator.authorWiegers, Eveline
dc.creator.authorWilliams, Guy
dc.creator.authorWilson, Lindsay
dc.creator.authorWinzeck, Stefan
dc.creator.authorWolf, Stefan
dc.creator.authorYang, Zhihui
dc.creator.authorYlén, Peter
dc.creator.authorYounsi, Alexander
dc.creator.authorZeiler, Frederick A.
dc.creator.authorZelinkova, Veronika
dc.creator.authorZiverte, Agate
dc.creator.authorZoerle, Tommaso
cristin.unitcode185,53,42,10
cristin.unitnameFysikalsk medisin og rehabilitering
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode2
dc.identifier.cristin2060796
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dc.identifier.jtitleNature Communications
dc.identifier.volume13
dc.identifier.issue1
dc.identifier.doihttps://doi.org/10.1038/s41467-022-30227-5
dc.type.documentTidsskriftartikkel
dc.type.peerreviewedPeer reviewed
dc.source.issn2041-1723
dc.type.versionPublishedVersion
cristin.articleid2545


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