dc.date.accessioned | 2022-11-14T17:29:22Z | |
dc.date.available | 2022-11-14T17:29:22Z | |
dc.date.created | 2022-08-22T11:08:23Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Kvamme, Jan-Magnus Sørbye, Sveinung Florholmen, Jon Halstensen, Trond S. . Population-based screening for celiac disease reveals that the majority of patients are undiagnosed and improve on a gluten-free diet. Scientific Reports. 2022, 12(1) | |
dc.identifier.uri | http://hdl.handle.net/10852/97564 | |
dc.description.abstract | Abstract The impact of a gluten-free diet (GFD) on screen-detected celiac disease (CD) is currently ambiguous. We aimed to identify the population-based prevalence of undiagnosed adult CD and examine the impact of a GFD on screen-detected CD. In total, 12,981 adults participated in a population-based health study in Tromsø, Norway. Participants with increased levels of anti-tissue transglutaminase-2 IgA or anti-deamidated gliadin peptide IgG were invited to undergo gastroduodenoscopy with both histological and immunohistochemical examination of small-bowel biopsies. The prevalence of previously diagnosed CD was 0.37%. Additionally, the prevalence of previously undiagnosed CD was 1.10%. Thus, 1.47% of the population had CD, of whom 75% were previously undiagnosed. A GFD resulted in significant improvements in overall gastrointestinal symptoms, diarrhea, and health-related quality of life, with reduced abdominal discomfort (76%) and improved levels of energy (58%). The large majority of patients with adult CD were undiagnosed and benefited from a GFD with reduced gastrointestinal symptoms and improved health-related quality of life. In clinical practice, there should be a low threshold for CD testing even in the absence of abdominal complaints because most adult patients appear to consider their symptoms a part of their normal state and therefore remain untested and undiagnosed. Trial registration: Clinical Trials. Gov Identifier: NCT01695681. | |
dc.language | EN | |
dc.publisher | Nature Portfolio | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | Population-based screening for celiac disease reveals that the majority of patients are undiagnosed and improve on a gluten-free diet | |
dc.title.alternative | ENEngelskEnglishPopulation-based screening for celiac disease reveals that the majority of patients are undiagnosed and improve on a gluten-free diet | |
dc.type | Journal article | |
dc.creator.author | Kvamme, Jan-Magnus | |
dc.creator.author | Sørbye, Sveinung | |
dc.creator.author | Florholmen, Jon | |
dc.creator.author | Halstensen, Trond S. | |
cristin.unitcode | 185,16,15,0 | |
cristin.unitname | Institutt for oral biologi | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 2044887 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Scientific Reports&rft.volume=12&rft.spage=&rft.date=2022 | |
dc.identifier.jtitle | Scientific Reports | |
dc.identifier.volume | 12 | |
dc.identifier.issue | 1 | |
dc.identifier.pagecount | 0 | |
dc.identifier.doi | https://doi.org/10.1038/s41598-022-16705-2 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 2045-2322 | |
dc.type.version | PublishedVersion | |
cristin.articleid | 12647 | |