dc.date.accessioned | 2022-11-01T16:37:11Z | |
dc.date.available | 2023-03-13T23:46:01Z | |
dc.date.created | 2022-09-28T06:50:50Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Cheng, Weiqiu van der Meer, Dennis Parker, Nadine Hindley, Guy Frederick Lanyon O'Connell, Kevin Sean Wang, Yunpeng Shadrin, Alexey Alnæs, Dag Bahrami, Shahram Lin, Aihua Karadag, Naz Holen, Børge Fernández-Cabello, Sara Fan, Chun-Chieh Dale, Anders Djurovic, Srdjan Westlye, Lars Tjelta Frei, Oleksandr Smeland, Olav Bjerkehagen Andreassen, Ole . Shared genetic architecture between schizophrenia and subcortical brain volumes implicates early neurodevelopmental processes and brain development in childhood. Molecular Psychiatry. 2022 | |
dc.identifier.uri | http://hdl.handle.net/10852/97432 | |
dc.description.abstract | Patients with schizophrenia have consistently shown brain volumetric abnormalities, implicating both etiological and pathological processes. However, the genetic relationship between schizophrenia and brain volumetric abnormalities remains poorly understood. Here, we applied novel statistical genetic approaches (MiXeR and conjunctional false discovery rate analysis) to investigate genetic overlap with mixed effect directions using independent genome-wide association studies of schizophrenia (n = 130,644) and brain volumetric phenotypes, including subcortical brain and intracranial volumes (n = 33,735). We found brain volumetric phenotypes share substantial genetic variants (74–96%) with schizophrenia, and observed 107 distinct shared loci with sign consistency in independent samples. Genes mapped by shared loci revealed (1) significant enrichment in neurodevelopmental biological processes, (2) three co-expression clusters with peak expression at the prenatal stage, and (3) genetically imputed thalamic expression of CRHR1 and ARL17A was associated with the thalamic volume as early as in childhood. Together, our findings provide evidence of shared genetic architecture between schizophrenia and brain volumetric phenotypes and suggest that altered early neurodevelopmental processes and brain development in childhood may be involved in schizophrenia development. | |
dc.language | EN | |
dc.title | Shared genetic architecture between schizophrenia and subcortical brain volumes implicates early neurodevelopmental processes and brain development in childhood | |
dc.title.alternative | ENEngelskEnglishShared genetic architecture between schizophrenia and subcortical brain volumes implicates early neurodevelopmental processes and brain development in childhood | |
dc.type | Journal article | |
dc.creator.author | Cheng, Weiqiu | |
dc.creator.author | van der Meer, Dennis | |
dc.creator.author | Parker, Nadine | |
dc.creator.author | Hindley, Guy Frederick Lanyon | |
dc.creator.author | O'Connell, Kevin Sean | |
dc.creator.author | Wang, Yunpeng | |
dc.creator.author | Shadrin, Alexey | |
dc.creator.author | Alnæs, Dag | |
dc.creator.author | Bahrami, Shahram | |
dc.creator.author | Lin, Aihua | |
dc.creator.author | Karadag, Naz | |
dc.creator.author | Holen, Børge | |
dc.creator.author | Fernández-Cabello, Sara | |
dc.creator.author | Fan, Chun-Chieh | |
dc.creator.author | Dale, Anders | |
dc.creator.author | Djurovic, Srdjan | |
dc.creator.author | Westlye, Lars Tjelta | |
dc.creator.author | Frei, Oleksandr | |
dc.creator.author | Smeland, Olav Bjerkehagen | |
dc.creator.author | Andreassen, Ole | |
cristin.unitcode | 185,53,10,70 | |
cristin.unitname | NORMENT part UiO | |
cristin.ispublished | true | |
cristin.fulltext | postprint | |
cristin.qualitycode | 2 | |
dc.identifier.cristin | 2056112 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Molecular Psychiatry&rft.volume=&rft.spage=&rft.date=2022 | |
dc.identifier.jtitle | Molecular Psychiatry | |
dc.identifier.doi | https://doi.org/10.1038/s41380-022-01751-z | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 1359-4184 | |
dc.type.version | AcceptedVersion | |