Neuroanatomical heterogeneity and homogeneity in individuals at clinical high risk for psychosis
dc.date.accessioned | 2022-10-28T15:05:55Z | |
dc.date.available | 2022-10-28T15:05:55Z | |
dc.date.created | 2022-10-21T12:51:30Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Baldwin, Helen Radua, Joaquim Antoniades, Mathilde Haas, Shalaila S. Frangou, Sophia Agartz, Ingrid Allen, Paul Andreassen, Ole Atkinson, Kimberley Bachman, Peter Baeza, Inmaculada Bartholomeusz, Cali F. Chee, Michael W. L. Colibazzi, Tiziano Cooper, Rebecca E. Corcoran, Cheryl M. Cropley, Vanessa L. Ebdrup, Bjørn H. Fortea, Adriana Glenthøj, Louise Birkedal Hamilton, Holly K. Haut, Kristen M. Hayes, Rebecca A. He, Ying Heekeren, Karsten Kaess, Michael Kasai, Kiyoto Katagiri, Naoyuki Kim, Minah Kindler, Jochen Klaunig, Mallory J. Koike, Shinsuke Koppel, Alex Kristensen, Tina D. Bin Kwak, Yoo Kwon, Jun Soo Lawrie, Stephen M. Lebedeva, Irina Lee, Jimmy Lin, Ashleigh Loewy, Rachel L. Mathalon, Daniel H. Michel, Chantal Mizrahi, Romina Møller, Paul Nelson, Barnaby Nemoto, Takahiro Nordholm, Dorte Omelchenko, Maria A. Pantelis, Christos Raghava, Jayachandra M. Røssberg, Jan Ivar Rössler, Wulf Salisbury, Dean F. Sasabayashi, Daiki Schall, Ulrich Smigielski, Lukasz Sugranyes, Gisela Suzuki, Michio Takahashi, Tsutomu Tamnes, Christian Krog Tang, Jinsong Theodoridou, Anastasia Thomopoulos, Sophia I. Tomyshev, Alexander S. Uhlhaas, Peter J. Værnes, Tor Gunnar van Amelsvoort, Therese A. M. J. Van Erp, Theo G. M. Waltz, James A. Westlye, Lars Tjelta Wood, Stephen J. Zhou, Juan H. McGuire, Philip Thompson, Paul M. Jalbrzikowski, Maria Hernaus, Dennis Fusar-Poli, Paolo de la Fuente-Sandoval, Camilo Catalano, Sabrina Hubl, Daniela Schiffman, Jason Venegoni, Enea D. Hooker, Christine I. Rasser, Paul E. Hegelstad, Wenche Resch, Franz Lemmers-Jansen, Imke L. J. Amminger, G. Paul Chen, Xiaogang Cho, Kang Ik K. Glenthøj, Birte Yding de Haan, Lieuwe Harris, Matthew A. Hwang, Wu Jeong León-Ortiz, Pablo Ma, Xiaoqian McGorry, Patrick Mora-Durán, Ricardo Mizuno, Masafumi Nordentoft, Merete Ouyang, Lijun Pariente, Jose C. Reyes-Madrigal, Francisco Sørensen, Mikkel E. Velakoulis, Dennis Vinogradov, Sophia Wenneberg, Christina Yamasue, Hidenori Yuan, Liu Yung, Alison R. . Neuroanatomical heterogeneity and homogeneity in individuals at clinical high risk for psychosis. Translational Psychiatry. 2022, 12(1) | |
dc.identifier.uri | http://hdl.handle.net/10852/97367 | |
dc.description.abstract | Abstract Individuals at Clinical High Risk for Psychosis (CHR-P) demonstrate heterogeneity in clinical profiles and outcome features. However, the extent of neuroanatomical heterogeneity in the CHR-P state is largely undetermined. We aimed to quantify the neuroanatomical heterogeneity in structural magnetic resonance imaging measures of cortical surface area (SA), cortical thickness (CT), subcortical volume (SV), and intracranial volume (ICV) in CHR-P individuals compared with healthy controls (HC), and in relation to subsequent transition to a first episode of psychosis. The ENIGMA CHR-P consortium applied a harmonised analysis to neuroimaging data across 29 international sites, including 1579 CHR-P individuals and 1243 HC, offering the largest pooled CHR-P neuroimaging dataset to date. Regional heterogeneity was indexed with the Variability Ratio (VR) and Coefficient of Variation (CV) ratio applied at the group level. Personalised estimates of heterogeneity of SA, CT and SV brain profiles were indexed with the novel Person-Based Similarity Index (PBSI), with two complementary applications. First, to assess the extent of within-diagnosis similarity or divergence of neuroanatomical profiles between individuals. Second, using a normative modelling approach, to assess the ‘normativeness’ of neuroanatomical profiles in individuals at CHR-P. CHR-P individuals demonstrated no greater regional heterogeneity after applying FDR corrections. However, PBSI scores indicated significantly greater neuroanatomical divergence in global SA, CT and SV profiles in CHR-P individuals compared with HC. Normative PBSI analysis identified 11 CHR-P individuals (0.70%) with marked deviation (>1.5 SD) in SA, 118 (7.47%) in CT and 161 (10.20%) in SV. Psychosis transition was not significantly associated with any measure of heterogeneity. Overall, our examination of neuroanatomical heterogeneity within the CHR-P state indicated greater divergence in neuroanatomical profiles at an individual level, irrespective of psychosis conversion. Further large-scale investigations are required of those who demonstrate marked deviation. | |
dc.language | EN | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | Neuroanatomical heterogeneity and homogeneity in individuals at clinical high risk for psychosis | |
dc.title.alternative | ENEngelskEnglishNeuroanatomical heterogeneity and homogeneity in individuals at clinical high risk for psychosis | |
dc.type | Journal article | |
dc.creator.author | Baldwin, Helen | |
dc.creator.author | Radua, Joaquim | |
dc.creator.author | Antoniades, Mathilde | |
dc.creator.author | Haas, Shalaila S. | |
dc.creator.author | Frangou, Sophia | |
dc.creator.author | Agartz, Ingrid | |
dc.creator.author | Allen, Paul | |
dc.creator.author | Andreassen, Ole | |
dc.creator.author | Atkinson, Kimberley | |
dc.creator.author | Bachman, Peter | |
dc.creator.author | Baeza, Inmaculada | |
dc.creator.author | Bartholomeusz, Cali F. | |
dc.creator.author | Chee, Michael W. L. | |
dc.creator.author | Colibazzi, Tiziano | |
dc.creator.author | Cooper, Rebecca E. | |
dc.creator.author | Corcoran, Cheryl M. | |
dc.creator.author | Cropley, Vanessa L. | |
dc.creator.author | Ebdrup, Bjørn H. | |
dc.creator.author | Fortea, Adriana | |
dc.creator.author | Glenthøj, Louise Birkedal | |
dc.creator.author | Hamilton, Holly K. | |
dc.creator.author | Haut, Kristen M. | |
dc.creator.author | Hayes, Rebecca A. | |
dc.creator.author | He, Ying | |
dc.creator.author | Heekeren, Karsten | |
dc.creator.author | Kaess, Michael | |
dc.creator.author | Kasai, Kiyoto | |
dc.creator.author | Katagiri, Naoyuki | |
dc.creator.author | Kim, Minah | |
dc.creator.author | Kindler, Jochen | |
dc.creator.author | Klaunig, Mallory J. | |
dc.creator.author | Koike, Shinsuke | |
dc.creator.author | Koppel, Alex | |
dc.creator.author | Kristensen, Tina D. | |
dc.creator.author | Bin Kwak, Yoo | |
dc.creator.author | Kwon, Jun Soo | |
dc.creator.author | Lawrie, Stephen M. | |
dc.creator.author | Lebedeva, Irina | |
dc.creator.author | Lee, Jimmy | |
dc.creator.author | Lin, Ashleigh | |
dc.creator.author | Loewy, Rachel L. | |
dc.creator.author | Mathalon, Daniel H. | |
dc.creator.author | Michel, Chantal | |
dc.creator.author | Mizrahi, Romina | |
dc.creator.author | Møller, Paul | |
dc.creator.author | Nelson, Barnaby | |
dc.creator.author | Nemoto, Takahiro | |
dc.creator.author | Nordholm, Dorte | |
dc.creator.author | Omelchenko, Maria A. | |
dc.creator.author | Pantelis, Christos | |
dc.creator.author | Raghava, Jayachandra M. | |
dc.creator.author | Røssberg, Jan Ivar | |
dc.creator.author | Rössler, Wulf | |
dc.creator.author | Salisbury, Dean F. | |
dc.creator.author | Sasabayashi, Daiki | |
dc.creator.author | Schall, Ulrich | |
dc.creator.author | Smigielski, Lukasz | |
dc.creator.author | Sugranyes, Gisela | |
dc.creator.author | Suzuki, Michio | |
dc.creator.author | Takahashi, Tsutomu | |
dc.creator.author | Tamnes, Christian Krog | |
dc.creator.author | Tang, Jinsong | |
dc.creator.author | Theodoridou, Anastasia | |
dc.creator.author | Thomopoulos, Sophia I. | |
dc.creator.author | Tomyshev, Alexander S. | |
dc.creator.author | Uhlhaas, Peter J. | |
dc.creator.author | Værnes, Tor Gunnar | |
dc.creator.author | van Amelsvoort, Therese A. M. J. | |
dc.creator.author | Van Erp, Theo G. M. | |
dc.creator.author | Waltz, James A. | |
dc.creator.author | Westlye, Lars Tjelta | |
dc.creator.author | Wood, Stephen J. | |
dc.creator.author | Zhou, Juan H. | |
dc.creator.author | McGuire, Philip | |
dc.creator.author | Thompson, Paul M. | |
dc.creator.author | Jalbrzikowski, Maria | |
dc.creator.author | Hernaus, Dennis | |
dc.creator.author | Fusar-Poli, Paolo | |
dc.creator.author | de la Fuente-Sandoval, Camilo | |
dc.creator.author | Catalano, Sabrina | |
dc.creator.author | Hubl, Daniela | |
dc.creator.author | Schiffman, Jason | |
dc.creator.author | Venegoni, Enea D. | |
dc.creator.author | Hooker, Christine I. | |
dc.creator.author | Rasser, Paul E. | |
dc.creator.author | Hegelstad, Wenche | |
dc.creator.author | Resch, Franz | |
dc.creator.author | Lemmers-Jansen, Imke L. J. | |
dc.creator.author | Amminger, G. Paul | |
dc.creator.author | Chen, Xiaogang | |
dc.creator.author | Cho, Kang Ik K. | |
dc.creator.author | Glenthøj, Birte Yding | |
dc.creator.author | de Haan, Lieuwe | |
dc.creator.author | Harris, Matthew A. | |
dc.creator.author | Hwang, Wu Jeong | |
dc.creator.author | León-Ortiz, Pablo | |
dc.creator.author | Ma, Xiaoqian | |
dc.creator.author | McGorry, Patrick | |
dc.creator.author | Mora-Durán, Ricardo | |
dc.creator.author | Mizuno, Masafumi | |
dc.creator.author | Nordentoft, Merete | |
dc.creator.author | Ouyang, Lijun | |
dc.creator.author | Pariente, Jose C. | |
dc.creator.author | Reyes-Madrigal, Francisco | |
dc.creator.author | Sørensen, Mikkel E. | |
dc.creator.author | Velakoulis, Dennis | |
dc.creator.author | Vinogradov, Sophia | |
dc.creator.author | Wenneberg, Christina | |
dc.creator.author | Yamasue, Hidenori | |
dc.creator.author | Yuan, Liu | |
dc.creator.author | Yung, Alison R. | |
cristin.unitcode | 185,53,10,11 | |
cristin.unitname | Senter for psykoseforskning | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 2063708 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Translational Psychiatry&rft.volume=12&rft.spage=&rft.date=2022 | |
dc.identifier.jtitle | Translational Psychiatry | |
dc.identifier.volume | 12 | |
dc.identifier.issue | 1 | |
dc.identifier.pagecount | 0 | |
dc.identifier.doi | https://doi.org/10.1038/s41398-022-02057-y | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 2158-3188 | |
dc.type.version | PublishedVersion | |
cristin.articleid | 297 |
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Psykologisk institutt [4403]
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Institutt for klinisk medisin [10814]
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