dc.date.accessioned | 2022-10-26T16:53:11Z | |
dc.date.available | 2022-10-26T16:53:11Z | |
dc.date.created | 2022-09-26T16:08:13Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Thieu, Minh Khai Le Stoetzel, Sabine Rahmati, Maryam El Khassawna, Thaqif Verket, Anders Sanz-Esporrin, Javier Sanz Alonso, Mariano Ellingsen, Jan Eirik Haugen, Håvard Jostein . Immunohistochemical comparison of lateral bone augmentation using a synthetic TiO2 block or a xenogeneic graft in chronic alveolar defects. Clinical Implant Dentistry and Related Research. 2022 | |
dc.identifier.uri | http://hdl.handle.net/10852/97323 | |
dc.description.abstract | Objectives To evaluate osteogenic markers and alveolar ridge profile changes in guided bone regeneration (GBR) of chronic non-contained bone defects using a non-resorbable TiO2 block. Material and methods Three buccal bone defects were created in each hemimandible of eight beagle dogs and allowed to heal for 8 weeks before GBR. Treatment was assigned by block randomisation: TiO2 block: TiO2-scaffold and a collagen membrane, DBBM particulates: Deproteinised bovine bone mineral (DBBM) and a collagen membrane, Empty control: Only collagen membrane. Bone regeneration was assessed on two different healing timepoints: early (4 weeks) and late healing (12 weeks) using several immunohistochemistry markers including alpha smooth muscle actin (α-SMA), osteopontin, osteocalcin, tartrate-resistant acid phosphatase and collagen type I. Histomorphometry was performed on Movat Pentachrome and Von Kossa/Van Gieson stained sections. Stereolithographic models were used to compare alveolar profile changes. Results The percentage of α-SMA and osteopontin increased in TiO2 group after 12 weeks of healing at the bone-scaffold interface, while collagen type I increased in the empty control group. In the defect area, α-SMA decreased in the empty control group, while collagen type I increased in the DBBM group. All groups maintained alveolar profile from 4 to 12 weeks, but TiO2 group demonstrated the widest soft tissue contour profile. Conclusions The present findings suggested contact osteogenesis when GBR is performed with a TiO2 block or DBBM particulates. The increase in osteopontin indicated a potential for bone formation beyond 12 weeks. The alveolar profile data indicated a sustained lateral increase in lateral bone augmentation using a TiO2 block and a collagen membrane, as compared to DBBM and a collagen membrane or a collagen membrane alone. | |
dc.language | EN | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | Immunohistochemical comparison of lateral bone augmentation using a synthetic TiO2 block or a xenogeneic graft in chronic alveolar defects | |
dc.title.alternative | ENEngelskEnglishImmunohistochemical comparison of lateral bone augmentation using a synthetic TiO2 block or a xenogeneic graft in chronic alveolar defects | |
dc.type | Journal article | |
dc.creator.author | Thieu, Minh Khai Le | |
dc.creator.author | Stoetzel, Sabine | |
dc.creator.author | Rahmati, Maryam | |
dc.creator.author | El Khassawna, Thaqif | |
dc.creator.author | Verket, Anders | |
dc.creator.author | Sanz-Esporrin, Javier | |
dc.creator.author | Sanz Alonso, Mariano | |
dc.creator.author | Ellingsen, Jan Eirik | |
dc.creator.author | Haugen, Håvard Jostein | |
cristin.unitcode | 185,16,17,62 | |
cristin.unitname | Biomaterialer | |
cristin.ispublished | true | |
cristin.fulltext | preprint | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 2055624 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Clinical Implant Dentistry and Related Research&rft.volume=&rft.spage=&rft.date=2022 | |
dc.identifier.jtitle | Clinical Implant Dentistry and Related Research | |
dc.identifier.doi | https://doi.org/10.1111/cid.13143 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 1523-0899 | |
dc.type.version | PublishedVersion | |
dc.relation.project | NFR/231530 | |
dc.relation.project | EC/H2020/811226 | |