dc.date.accessioned | 2022-10-26T16:52:14Z | |
dc.date.available | 2022-10-26T16:52:14Z | |
dc.date.created | 2022-09-14T12:53:33Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Brune, Synne Høgestøl, Einar August de Rodez Benavent, Sigrid Aune Berg-Hansen, Pål Beyer, Mona K. Leikfoss, Ingvild Sørum Bos, Steffan Daniel Sowa, Piotr Brunborg, Cathrine Andorra, Magi Pulido Valdeolivas, Irene Asseyer, Susanna Brandt, Alexander Chien, Claudia Scheel, Michael Blennow, Kaj Zetterberg, Henrik Kerlero de Rosbo, Nicole Paul, Friedemann Uccelli, Antonio Villoslada, Pablo Berge, Tone Harbo, Hanne-Cathrin Flinstad . Serum neurofilament light chain concentration predicts disease worsening in multiple sclerosis. Multiple Sclerosis. 2022, 28(12), 1859-1870 | |
dc.identifier.uri | http://hdl.handle.net/10852/97322 | |
dc.description.abstract | Background: Serum neurofilament light (sNfL) chain is a promising biomarker reflecting neuro-axonal injury in multiple sclerosis (MS). However, the ability of sNfL to predict outcomes in real-world MS cohorts requires further validation. Objective: The aim of the study is to investigate the associations of sNfL concentration, magnetic resonance imaging (MRI) and retinal optical coherence tomography (OCT) markers with disease worsening in a longitudinal European multicentre MS cohort. Methods: MS patients ( n = 309) were prospectively enrolled at four centres and re-examined after 2 years ( n = 226). NfL concentration was measured by single molecule array assay in serum. The patients’ phenotypes were thoroughly characterized with clinical examination, retinal OCT and MRI brain scans. The primary outcome was disease worsening at median 2-year follow-up. Results: Patients with high sNfL concentrations (⩾8 pg/mL) at baseline had increased risk of disease worsening at median 2-year follow-up (odds ratio (95% confidence interval) = 2.8 (1.5–5.3), p = 0.001). We found no significant associations of MRI or OCT measures at baseline with risk of disease worsening. Conclusion: Serum NfL concentration was the only factor associated with disease worsening, indicating that sNfL is a useful biomarker in MS that might be relevant in a clinical setting. | |
dc.language | EN | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | Serum neurofilament light chain concentration predicts disease worsening in multiple sclerosis | |
dc.title.alternative | ENEngelskEnglishSerum neurofilament light chain concentration predicts disease worsening in multiple sclerosis | |
dc.type | Journal article | |
dc.creator.author | Brune, Synne | |
dc.creator.author | Høgestøl, Einar August | |
dc.creator.author | de Rodez Benavent, Sigrid Aune | |
dc.creator.author | Berg-Hansen, Pål | |
dc.creator.author | Beyer, Mona K. | |
dc.creator.author | Leikfoss, Ingvild Sørum | |
dc.creator.author | Bos, Steffan Daniel | |
dc.creator.author | Sowa, Piotr | |
dc.creator.author | Brunborg, Cathrine | |
dc.creator.author | Andorra, Magi | |
dc.creator.author | Pulido Valdeolivas, Irene | |
dc.creator.author | Asseyer, Susanna | |
dc.creator.author | Brandt, Alexander | |
dc.creator.author | Chien, Claudia | |
dc.creator.author | Scheel, Michael | |
dc.creator.author | Blennow, Kaj | |
dc.creator.author | Zetterberg, Henrik | |
dc.creator.author | Kerlero de Rosbo, Nicole | |
dc.creator.author | Paul, Friedemann | |
dc.creator.author | Uccelli, Antonio | |
dc.creator.author | Villoslada, Pablo | |
dc.creator.author | Berge, Tone | |
dc.creator.author | Harbo, Hanne-Cathrin Flinstad | |
cristin.unitcode | 185,53,42,13 | |
cristin.unitname | Nevrologisk avdeling | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 2051614 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Multiple Sclerosis&rft.volume=28&rft.spage=1859&rft.date=2022 | |
dc.identifier.jtitle | Multiple Sclerosis | |
dc.identifier.volume | 28 | |
dc.identifier.issue | 12 | |
dc.identifier.startpage | 1859 | |
dc.identifier.endpage | 1870 | |
dc.identifier.doi | https://doi.org/10.1177/13524585221097296 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 1352-4585 | |
dc.type.version | PublishedVersion | |