dc.date.accessioned | 2022-09-20T15:02:30Z | |
dc.date.available | 2022-09-20T15:02:30Z | |
dc.date.created | 2022-07-25T10:41:56Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Ellinghaus, David Degenhardt, Frauke Juzenas, Simonas Lerga-Jaso, Jon Wendorff, Mareike Maya-Miles, Douglas Uellendahl-Werth, Florian ElAbd, Hesham Lenning, Ole Bernt Myhre, Ronny Vadla, May Sissel Holten, Aleksander Rygh Kildal, Anders Benjamin Lind, Andreas Dyrhol-Riise, Anne Ma Hoff, Dag Arne Lihaug Müller, Fredrik Solligård, Erik Holter, Jan Cato Afset, Jan Egil Damås, Jan Kristian Bergan, Jonas Risnes, Kari Muller, Karl Erik Tonby, Kristian Heggelund, Lars Tuset Gustad, Trine Grimsrud, Marit Mæhle Dudman, Susanne Gjeruldsen Folseraas, Trine Skogen, Vegard Hov, Johannes Espolin Roksund Karlsen, Tom Hemming . Detailed stratified GWAS analysis for severe COVID-19 in four European populations. Human Molecular Genetics. 2022 | |
dc.identifier.uri | http://hdl.handle.net/10852/96733 | |
dc.description.abstract | Abstract
Given the highly variable clinical phenotype of Coronavirus disease 2019 (COVID-19), a deeper analysis of the host genetic contribution to severe COVID-19 is important to improve our understanding of underlying disease mechanisms. Here, we describe an extended GWAS meta-analysis of a well-characterized cohort of 3255 COVID-19 patients with respiratory failure and 12 488 population controls from Italy, Spain, Norway and Germany/Austria, including stratified analyses based on age, sex and disease severity, as well as targeted analyses of chromosome Y haplotypes, the human leukocyte antigen (HLA) region and the SARS-CoV-2 peptidome. By inversion imputation, we traced a reported association at 17q21.31 to a ~ 0.9-Mb inversion polymorphism that creates two highly differentiated haplotypes and characterized the potential effects of the inversion in detail. Our data, together with the 5th release of summary statistics from the COVID-19 Host Genetics Initiative including non-Caucasian individuals, also identified a new locus at 19q13.33, including NAPSA, a gene which is expressed primarily in alveolar cells responsible for gas exchange in the lung. | |
dc.language | EN | |
dc.rights | Attribution-NonCommercial 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | |
dc.title | Detailed stratified GWAS analysis for severe COVID-19 in four European populations | |
dc.title.alternative | ENEngelskEnglishDetailed stratified GWAS analysis for severe COVID-19 in four European populations | |
dc.type | Journal article | |
dc.creator.author | Ellinghaus, David | |
dc.creator.author | Degenhardt, Frauke | |
dc.creator.author | Juzenas, Simonas | |
dc.creator.author | Lerga-Jaso, Jon | |
dc.creator.author | Wendorff, Mareike | |
dc.creator.author | Maya-Miles, Douglas | |
dc.creator.author | Uellendahl-Werth, Florian | |
dc.creator.author | ElAbd, Hesham | |
dc.creator.author | Lenning, Ole Bernt | |
dc.creator.author | Myhre, Ronny | |
dc.creator.author | Vadla, May Sissel | |
dc.creator.author | Holten, Aleksander Rygh | |
dc.creator.author | Kildal, Anders Benjamin | |
dc.creator.author | Lind, Andreas | |
dc.creator.author | Dyrhol-Riise, Anne Ma | |
dc.creator.author | Hoff, Dag Arne Lihaug | |
dc.creator.author | Müller, Fredrik | |
dc.creator.author | Solligård, Erik | |
dc.creator.author | Holter, Jan Cato | |
dc.creator.author | Afset, Jan Egil | |
dc.creator.author | Damås, Jan Kristian | |
dc.creator.author | Bergan, Jonas | |
dc.creator.author | Risnes, Kari | |
dc.creator.author | Muller, Karl Erik | |
dc.creator.author | Tonby, Kristian | |
dc.creator.author | Heggelund, Lars | |
dc.creator.author | Tuset Gustad, Trine | |
dc.creator.author | Grimsrud, Marit Mæhle | |
dc.creator.author | Dudman, Susanne Gjeruldsen | |
dc.creator.author | Folseraas, Trine | |
dc.creator.author | Skogen, Vegard | |
dc.creator.author | Hov, Johannes Espolin Roksund | |
dc.creator.author | Karlsen, Tom Hemming | |
cristin.unitcode | 185,53,11,14 | |
cristin.unitname | Infeksjonsmedisinsk avdeling | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |
dc.identifier.cristin | 2039299 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Human Molecular Genetics&rft.volume=&rft.spage=&rft.date=2022 | |
dc.identifier.jtitle | Human Molecular Genetics | |
dc.identifier.doi | https://doi.org/10.1093/hmg/ddac158 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 0964-6906 | |
dc.type.version | PublishedVersion | |
cristin.articleid | ddac158 | |