dc.date.accessioned | 2022-09-16T16:00:20Z | |
dc.date.available | 2022-09-16T16:00:20Z | |
dc.date.created | 2022-06-02T14:14:36Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Li, Jing Zaslavsky, Maxim Su, Yapeng Guo, Jing Sikora, Michael J. van Unen, Vincent Christophersen, Asbjørn Otto Chiou, Shin-Heng Chen, Liang Li, Jiefu Ji, Xuhuai Wilhelmy, Julie McSween, Alana M. Palanski, Brad A. Mallajosyula, Venkata Vamsee Aditya Bracey, Nathan A. Dhondalay, Gopal Krishna R Bhamidipati, Kartik Pai, Joy Kipp, Lucas B. Dunn, Jeffrey E. Hauser, Stephen L. Oksenberg, Jorge R. Satpathy, Ansuman T. Robinson, William H. Dekker, Cornelia L. Steinmetz, Lars M. Khosla, Chaitan Utz, Paul J. Sollid, Ludvig Magne Chien, Yueh-Hsiu Heath, James R. Fernandez-Becker, Nielsen Q. Nadeau, Kari C. Saligrama, Naresha Davis, Mark M. . KIR+CD8+ T cells suppress pathogenic T cells and are active in autoimmune diseases and COVID-19. Science. 2022, 376:eabi9591(6590), 1-15 | |
dc.identifier.uri | http://hdl.handle.net/10852/96692 | |
dc.description.abstract | In this work, we find that CD8+ T cells expressing inhibitory killer cell immunoglobulin-like receptors (KIRs) are the human equivalent of Ly49+CD8+ regulatory T cells in mice and are increased in the blood and inflamed tissues of patients with a variety of autoimmune diseases. Moreover, these CD8+ T cells efficiently eliminated pathogenic gliadin-specific CD4+ T cells from the leukocytes of celiac disease patients in vitro. We also find elevated levels of KIR+CD8+ T cells, but not CD4+ regulatory T cells, in COVID-19 patients, correlating with disease severity and vasculitis. Selective ablation of Ly49+CD8+ T cells in virus-infected mice led to autoimmunity after infection. Our results indicate that in both species, these regulatory CD8+ T cells act specifically to suppress pathogenic T cells in autoimmune and infectious diseases. | |
dc.language | EN | |
dc.publisher | American Association for the Advancement of Science | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | KIR+CD8+ T cells suppress pathogenic T cells and are active in autoimmune diseases and COVID-19 | |
dc.title.alternative | ENEngelskEnglishKIR+CD8+ T cells suppress pathogenic T cells and are active in autoimmune diseases and COVID-19 | |
dc.type | Journal article | |
dc.creator.author | Li, Jing | |
dc.creator.author | Zaslavsky, Maxim | |
dc.creator.author | Su, Yapeng | |
dc.creator.author | Guo, Jing | |
dc.creator.author | Sikora, Michael J. | |
dc.creator.author | van Unen, Vincent | |
dc.creator.author | Christophersen, Asbjørn Otto | |
dc.creator.author | Chiou, Shin-Heng | |
dc.creator.author | Chen, Liang | |
dc.creator.author | Li, Jiefu | |
dc.creator.author | Ji, Xuhuai | |
dc.creator.author | Wilhelmy, Julie | |
dc.creator.author | McSween, Alana M. | |
dc.creator.author | Palanski, Brad A. | |
dc.creator.author | Mallajosyula, Venkata Vamsee Aditya | |
dc.creator.author | Bracey, Nathan A. | |
dc.creator.author | Dhondalay, Gopal Krishna R | |
dc.creator.author | Bhamidipati, Kartik | |
dc.creator.author | Pai, Joy | |
dc.creator.author | Kipp, Lucas B. | |
dc.creator.author | Dunn, Jeffrey E. | |
dc.creator.author | Hauser, Stephen L. | |
dc.creator.author | Oksenberg, Jorge R. | |
dc.creator.author | Satpathy, Ansuman T. | |
dc.creator.author | Robinson, William H. | |
dc.creator.author | Dekker, Cornelia L. | |
dc.creator.author | Steinmetz, Lars M. | |
dc.creator.author | Khosla, Chaitan | |
dc.creator.author | Utz, Paul J. | |
dc.creator.author | Sollid, Ludvig Magne | |
dc.creator.author | Chien, Yueh-Hsiu | |
dc.creator.author | Heath, James R. | |
dc.creator.author | Fernandez-Becker, Nielsen Q. | |
dc.creator.author | Nadeau, Kari C. | |
dc.creator.author | Saligrama, Naresha | |
dc.creator.author | Davis, Mark M. | |
cristin.unitcode | 185,53,18,73 | |
cristin.unitname | K.G. Jebsen senter for cøliakiforskning | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |
dc.identifier.cristin | 2029128 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Science&rft.volume=376:eabi9591&rft.spage=1&rft.date=2022 | |
dc.identifier.jtitle | Science | |
dc.identifier.volume | 376 | |
dc.identifier.doi | https://doi.org/10.1126/science.abi9591 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 0036-8075 | |
dc.type.version | PublishedVersion | |
cristin.articleid | eabi9591 | |
dc.relation.project | SKGJ/SKGJ-MED-017 | |