dc.date.accessioned | 2022-09-15T16:49:56Z | |
dc.date.available | 2022-09-15T16:49:56Z | |
dc.date.created | 2022-08-30T14:07:58Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Kørner, Hartwig Guren, Marianne Larsen, Inger Kristin Haugen, Dagny Renata Faksvåg Søreide, Kjetil Kørner, Leif Roland Søreide, Jon Arne . Characteristics and fate of patients with rectal cancer not entering a curative-intent treatment pathway: A complete nationwide registry cohort of 3,304 patients. European Journal of Surgical Oncology. 2022, 48(8), 1831-1839 | |
dc.identifier.uri | http://hdl.handle.net/10852/96655 | |
dc.description.abstract | Background
Treatment options for advanced and metastatic rectal cancer have increased during the past decades. However, a considerable proportion of the patients are not eligible for curative treatment, and data on this subset are scarce from a population-based perspective. This study aimed to describe treatment pathways and survival in a national cohort of patients with primary stage IV rectal cancer or stage I-III rectal cancer not eligible for curative treatment.
Methods
A national cohort of all patients reported 2008–2015 to the Norwegian Colorectal Cancer Registry with primary metastatic rectal cancer or who did not undergo curative resections for stage I-III rectal cancer was studied with regard to patient characteristics, treatments, and survival.
Results
Of 8291 patients diagnosed with rectal cancer, 3304 (39.9%) were eligible for analysis. The majority (76.8%) had metastatic disease, and 23.2% did not undergo curative resections for other reasons. We identified four main treatment journeys: no tumour-directed treatment, 25.1%; resection of the primary tumour, 44.6%; oncological treatment, 28.4%; and R0 resection of the primary tumour and metastases, 1.9%; these translated into ten different treatment pathways. Survival differed considerably between a median of 5.3 months for M1 disease with non-tumour-directed treatment to a five-year survival of 67% for M1 with R0 resection.
Conclusion
Almost 40% of all patients with rectal cancer did not enter a curative-intent treatment pathway. The patient journeys and outcomes varied greatly. This large but understudied population warrants further in-depth analyses of treatment efficacy and effects on quality of life. | |
dc.language | EN | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | Characteristics and fate of patients with rectal cancer not entering a curative-intent treatment pathway: A complete nationwide registry cohort of 3,304 patients | |
dc.title.alternative | ENEngelskEnglishCharacteristics and fate of patients with rectal cancer not entering a curative-intent treatment pathway: A complete nationwide registry cohort of 3,304 patients | |
dc.type | Journal article | |
dc.creator.author | Kørner, Hartwig | |
dc.creator.author | Guren, Marianne | |
dc.creator.author | Larsen, Inger Kristin | |
dc.creator.author | Haugen, Dagny Renata Faksvåg | |
dc.creator.author | Søreide, Kjetil | |
dc.creator.author | Kørner, Leif Roland | |
dc.creator.author | Søreide, Jon Arne | |
cristin.unitcode | 185,53,49,10 | |
cristin.unitname | Kreftbehandling | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 2047238 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=European Journal of Surgical Oncology&rft.volume=48&rft.spage=1831&rft.date=2022 | |
dc.identifier.jtitle | European Journal of Surgical Oncology | |
dc.identifier.volume | 48 | |
dc.identifier.issue | 8 | |
dc.identifier.startpage | 1831 | |
dc.identifier.endpage | 1839 | |
dc.identifier.doi | https://doi.org/10.1016/j.ejso.2022.04.013 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 0748-7983 | |
dc.type.version | PublishedVersion | |