dc.date.accessioned | 2022-09-05T15:39:01Z | |
dc.date.available | 2022-09-05T15:39:01Z | |
dc.date.created | 2022-05-31T13:10:25Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Gorunova, Ludmila Pedersen, Kjetil Boye Panagopoulos, Ioannis Berner, Jeanne-Marie Bjerkehagen, Bodil Hompland, Ivar Lobmaier, Ingvild Victoria Koren Hølmebakk, Toto Hveem, Tarjei Sveinsgjerd Heim, Sverre Micci, Francesca . Cytogenetic and molecular analyses of 291 gastrointestinal stromal tumors: site-specific cytogenetic evolution as evidence of pathogenetic heterogeneity. OncoTarget. 2022, 13(1), 508-517 | |
dc.identifier.uri | http://hdl.handle.net/10852/96032 | |
dc.description.abstract | Gastrointestinal stromal tumor (GIST) is a mesenchymal neoplasm with variable behavior. An increased understanding of the tumor pathogenesis may improve clinical decision-making. Our aim was to obtain more data about the overall chromosome aberrations and intratumor cytogenetic heterogeneity in GIST. We analyzed 306 GIST samples from 291 patients using G-banding, direct sequencing, and statistics. Clonal chromosome aberrations were found in 81% of samples, with 34% of 226 primary tumors demonstrating extensive cytogenetic heterogeneity. 135 tumors had simple (≤5 changes) and 91 had complex (>5 changes) karyotypes. The karyotypically complex tumors more often were non-gastric (P < 0.001), larger (P < 0.001), more mitotically active (P = 0.009) and had a higher risk of rupture (P < 0.001) and recurrence (P < 0.001). Significant differences between gastric and non-gastric tumors were found also in the frequency of main chromosome losses: of 14q (79% vs. 63%), 22q (38% vs. 67%), 1p (23% vs. 88%), and 15q (18% vs. 77%). Gastric PDGFRA-mutated tumors, compared with gastric KIT-mutated, had a lower incidence of 22q losses (18% vs. 43%) but a higher rate of 1p losses (42% vs. 22%). The present, largest by far karyotypic study of GISTs provides further evidence for the existence of variable pathogenetic pathways operating in these tumors’ development. | |
dc.language | EN | |
dc.publisher | Impact Journals LLC | |
dc.rights | Attribution 3.0 Unported | |
dc.rights.uri | https://creativecommons.org/licenses/by/3.0/ | |
dc.title | Cytogenetic and molecular analyses of 291 gastrointestinal stromal tumors: site-specific cytogenetic evolution as evidence of pathogenetic heterogeneity | |
dc.title.alternative | ENEngelskEnglishCytogenetic and molecular analyses of 291 gastrointestinal stromal tumors: site-specific cytogenetic evolution as evidence of pathogenetic heterogeneity | |
dc.type | Journal article | |
dc.creator.author | Gorunova, Ludmila | |
dc.creator.author | Pedersen, Kjetil Boye | |
dc.creator.author | Panagopoulos, Ioannis | |
dc.creator.author | Berner, Jeanne-Marie | |
dc.creator.author | Bjerkehagen, Bodil | |
dc.creator.author | Hompland, Ivar | |
dc.creator.author | Lobmaier, Ingvild Victoria Koren | |
dc.creator.author | Hølmebakk, Toto | |
dc.creator.author | Hveem, Tarjei Sveinsgjerd | |
dc.creator.author | Heim, Sverre | |
dc.creator.author | Micci, Francesca | |
cristin.unitcode | 185,53,18,13 | |
cristin.unitname | Avdeling for patologi | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 2028418 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=OncoTarget&rft.volume=13&rft.spage=508&rft.date=2022 | |
dc.identifier.jtitle | OncoTarget | |
dc.identifier.volume | 13 | |
dc.identifier.issue | 1 | |
dc.identifier.startpage | 508 | |
dc.identifier.endpage | 517 | |
dc.identifier.doi | https://doi.org/10.18632/ONCOTARGET.28209 | |
dc.identifier.urn | URN:NBN:no-98556 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 1949-2553 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/96032/1/Postnr%2B2028418_Gorunova%2Bet%2Bal_oncotarget-v13-28209.pdf | |
dc.type.version | PublishedVersion | |
dc.relation.project | HSØ/2019064 | |