dc.date.accessioned | 2022-08-23T15:34:14Z | |
dc.date.available | 2022-08-23T15:34:14Z | |
dc.date.created | 2022-04-22T21:48:49Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Tanem, Kristine Eidal Stensvold, Einar Wilberg, Petter Skaare, Anne B Singh, Preet Bano Brandal, Petter Herlofson, Bente Brokstad . Taste and smell function in long-term survivors after childhood medulloblastoma/CNS-PNET. Supportive Care in Cancer. 2022, 6155-6162 | |
dc.identifier.uri | http://hdl.handle.net/10852/95558 | |
dc.description.abstract | Abstract
Purpose
To investigate taste and smell function in survivors, with a minimum of 2 years since treatment of childhood medulloblastoma (MB)/central nervous system supratentorial primitive neuroectodermal tumor (CNS-PNET).
Methods
This cross-sectional study included 40 survivors treated ≤ 20 years of age. Taste strips with four concentrations of sweet, sour, salt, and bitter were used to assess taste function in all participants. Score from 0 to 16; ≥ 9 normogeusia, < 9 hypogeusia, and complete ageusia which equals no sensation. No sensation of a specific taste quality equals ageusia of that quality. Thirty-two participants conducted smell testing using three subtests of Sniffin’ sticks: threshold, discrimination, and identification. Together they yield a TDI-score from 1 to 48; functional anosmia ≤ 16.00, hyposmia > 16.00– < 30.75, normosmia ≥ 30.75– < 41.50, and ≥ 41.50 hyperosmia. Results were compared with normative data. Survivors rated their taste and smell function using a numerical rating scale (NRS) score 0–10.
Results
Forty survivors with a mean time since treatment of 20.5 years, 13 (32.5%) were diagnosed with hypogeusia, nine (22.5%) of these being ageusic to one or more taste qualities. Seventeen (53%) of 32 participants were diagnosed with hyposmia. The mean scores of the olfactory subtests, and TDI score were significantly lower than normative data ( P < 0.0001). The mean NRS scores of smell and taste function were 7.9 ± 1.5 and 8 ± 1.3, respectively.
Conclusion
Our study showed impaired taste and smell function in survivors of childhood MB/CNS-PNET using objective measurements. However, subjective ratings did not reflect objective findings. | |
dc.language | EN | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | Taste and smell function in long-term survivors after childhood medulloblastoma/CNS-PNET | |
dc.title.alternative | ENEngelskEnglishTaste and smell function in long-term survivors after childhood medulloblastoma/CNS-PNET | |
dc.type | Journal article | |
dc.creator.author | Tanem, Kristine Eidal | |
dc.creator.author | Stensvold, Einar | |
dc.creator.author | Wilberg, Petter | |
dc.creator.author | Skaare, Anne B | |
dc.creator.author | Singh, Preet Bano | |
dc.creator.author | Brandal, Petter | |
dc.creator.author | Herlofson, Bente Brokstad | |
cristin.unitcode | 185,16,17,0 | |
cristin.unitname | Institutt for klinisk odontologi | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 2018544 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Supportive Care in Cancer&rft.volume=&rft.spage=6155&rft.date=2022 | |
dc.identifier.jtitle | Supportive Care in Cancer | |
dc.identifier.volume | 30 | |
dc.identifier.issue | 7 | |
dc.identifier.startpage | 6155 | |
dc.identifier.endpage | 6162 | |
dc.identifier.doi | https://doi.org/10.1007/s00520-022-07048-9 | |
dc.identifier.urn | URN:NBN:no-98065 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 0941-4355 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/95558/1/Taste%2Band%2Bsmell%2Bfunction%2Bin%2Blong%25E2%2580%2591term%2Bsurvivors%2Bafter%2Bchildhood.pdf | |
dc.type.version | PublishedVersion | |